Literature DB >> 28449496

The mechanisms of radioresistance in esophageal squamous cell carcinoma and current strategies in radiosensitivity.

Guang-Zong Chen1, Hong-Cheng Zhu1, Wang-Shu Dai1, Xiao-Ning Zeng2, Jin-Hua Luo3, Xin-Chen Sun1.   

Abstract

Esophageal cancer is the eighth most common cancer and the sixth leading cause of cancer-related death worldwide. Surgery is the primary form of treatment, but the survival is poor, especially for patients with locally advanced esophageal cancer. Radiotherapy has been a critical treatment option that may be combined with chemotherapy in patients with unresectable esophageal cancer. However, resistance to chemoradiotherapy might result in treatment failures and cancer relapse. This review will mainly focus on the possible cellular mechanisms and tumor-associated microenvironmental (TAM) factors that result in radioresistance in patients with esophageal cancer. In addition, current strategies to increase radiosensitivity, including targeted therapy and the use of radiosensitive biomarkers in clinical treatment, are discussed in this review.

Entities:  

Keywords:  Esophageal cancer; radioresistance; radiosensitive biomarker; targeted therapy; tumor-associated microenvironment (TAM)

Year:  2017        PMID： 28449496      PMCID： PMC5394057          DOI： 10.21037/jtd.2017.03.23

Source DB:  PubMed          Journal:  J Thorac Dis        ISSN： 2072-1439            Impact factor:   2.895


  68 in total

Review 1.  Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm.

Authors:  Subhra K Biswas; Alberto Mantovani
Journal:  Nat Immunol       Date:  2010-09-20       Impact factor: 25.606

2.  Serum proteomic profiling reveals that pretreatment complement protein levels are predictive of esophageal cancer patient response to neoadjuvant chemoradiation.

Authors:  Stephen G Maher; Dermot T McDowell; Ben C Collins; Cian Muldoon; William M Gallagher; John V Reynolds
Journal:  Ann Surg       Date:  2011-11       Impact factor: 12.969

Review 3.  Current status of predictive biomarkers for neoadjuvant therapy in esophageal cancer.

Authors:  Norihisa Uemura; Tadashi Kondo
Journal:  World J Gastrointest Pathophysiol       Date:  2014-08-15

4.  The immunological impact of neoadjuvant chemotherapy on the tumor microenvironment of esophageal squamous cell carcinoma.

Authors:  Takahiro Tsuchikawa; Masaki Miyamoto; Yoshiyuki Yamamura; Toshiaki Shichinohe; Satoshi Hirano; Satoshi Kondo
Journal:  Ann Surg Oncol       Date:  2011-08-06       Impact factor: 5.344

Review 5.  Targeting a cornerstone of radiation resistance: cancer stem cell.

Authors:  Coralie Moncharmont; Antonin Levy; Marion Gilormini; Gérald Bertrand; Cyrus Chargari; Gersende Alphonse; Dominique Ardail; Claire Rodriguez-Lafrasse; Nicolas Magné
Journal:  Cancer Lett       Date:  2012-03-27       Impact factor: 8.679

6.  Exosome transfer from stromal to breast cancer cells regulates therapy resistance pathways.

Authors:  Mirjam C Boelens; Tony J Wu; Barzin Y Nabet; Bihui Xu; Yu Qiu; Taewon Yoon; Diana J Azzam; Christina Twyman-Saint Victor; Brianne Z Wiemann; Hemant Ishwaran; Petra J Ter Brugge; Jos Jonkers; Joyce Slingerland; Andy J Minn
Journal:  Cell       Date:  2014-10-23       Impact factor: 41.582

7.  Circulating microRNAs in esophageal squamous cell carcinoma: association with locoregional staging and survival.

Authors:  Bing-Xin Li; Qi Yu; Ze-Liang Shi; Ping Li; Shen Fu
Journal:  Int J Clin Exp Med       Date:  2015-05-15

8.  Gene expression analysis of diagnostic biopsies predicts pathological response to neoadjuvant chemoradiotherapy of esophageal cancer.

Authors:  Stephen G Maher; Charles M Gillham; Shane P Duggan; Paul C Smyth; Nicola Miller; Cian Muldoon; Kenneth J O'Byrne; Orla M Sheils; Donal Hollywood; John V Reynolds
Journal:  Ann Surg       Date:  2009-11       Impact factor: 12.969

9.  Recombinant human endostatin enhances the radioresponse in esophageal squamous cell carcinoma by normalizing tumor vasculature and reducing hypoxia.

Authors:  Hongcheng Zhu; Xi Yang; Yuqiong Ding; Jia Liu; Jing Lu; Liangliang Zhan; Qin Qin; Hao Zhang; Xiaochen Chen; Yuehua Yang; Yan Yang; Zheming Liu; Meiling Yang; Xifa Zhou; Hongyan Cheng; Xinchen Sun
Journal:  Sci Rep       Date:  2015-09-28       Impact factor: 4.379

10.  Cranial irradiation alters the brain's microenvironment and permits CCR2+ macrophage infiltration.

Authors:  Josh M Morganti; Timothy D Jopson; Sharon Liu; Nalin Gupta; Susanna Rosi
Journal:  PLoS One       Date:  2014-04-02       Impact factor: 3.240
View more
  26 in total

1.  Downregulation of lncRNA ANRIL inhibits proliferation, induces apoptosis, and enhances radiosensitivity in nasopharyngeal carcinoma cells through regulating miR-125a.

Authors:  Xigang Hu; Huijuan Jiang; Xiaojun Jiang
Journal:  Cancer Biol Ther       Date:  2017-04-12       Impact factor: 4.742

2.  Pretreatment 18F-FDG PET/CT-Derived Parameters in Predicting Clinical Outcomes of Locally Advanced Upper Third Esophageal Squamous Cell Carcinoma After Definitive Chemoradiation Therapy.

Authors:  Le Ngoc Ha; Nguyen Dinh Chau; Bui Quang Bieu; Mai Hong Son
Journal:  Nucl Med Mol Imaging       Date:  2022-05-10

3.  HuR Affects the Radiosensitivity of Esophageal Cancer by Regulating the EMT-Related Protein Snail.

Authors:  Yan Hu; Qing Li; Ke Yi; Chi Yang; Qingjun Lei; Guanghui Wang; Qianyun Wang; Xiaohui Xu
Journal:  Front Oncol       Date:  2022-05-19       Impact factor: 5.738

4.  CBX4 contributes to radioresistance by regulating autophagic activity in esophageal squamous cell carcinoma.

Authors:  Hongcheng Zhu; Hui Chen; Guangzong Chen; Ming Liu; Li Chu; Yu Gu; Yun Chen; Chi Zhang; Qin Qin; Yanan Chen; Weiwei Chen; Jianhong Fan; Yongzhan Nie; Junqiang Chen; Shixiu Wu; Xinchen Sun; Weixin Zhao; Kuaile Zhao
Journal:  Ann Transl Med       Date:  2022-09

5.  Ribosomal S6 protein kinase 4 promotes radioresistance in esophageal squamous cell carcinoma.

Authors:  Ming-Yang Li; Lin-Ni Fan; Dong-Hui Han; Zhou Yu; Jing Ma; Yi-Xiong Liu; Pei-Feng Li; Dan-Hui Zhao; Jia Chai; Lei Jiang; Shi-Liang Li; Juan-Juan Xiao; Qiu-Hong Duan; Jing Ye; Mei Shi; Yong-Zhan Nie; Kai-Chun Wu; Dezhong Joshua Liao; Yu Shi; Yan Wang; Qing-Guo Yan; Shuang-Ping Guo; Xiu-Wu Bian; Feng Zhu; Jian Zhang; Zhe Wang
Journal:  J Clin Invest       Date:  2020-08-03       Impact factor: 14.808

6.  Novel drug candidates for treating esophageal carcinoma: A study on differentially expressed genes, using connectivity mapping and molecular docking.

Authors:  Yu-Ting Chen; Jia-Yi Xie; Qi Sun; Wei-Jia Mo
Journal:  Int J Oncol       Date:  2018-11-02       Impact factor: 5.650

7.  Therapeutic benefits of niraparib tosylate as radio sensitizer in esophageal squamous cell carcinoma: an in vivo and in vitro preclinical study.

Authors:  Yuzhong Cui; Wei Huang; Feng Du; Xiaoyang Yin; Lei Feng; Baosheng Li
Journal:  Clin Transl Oncol       Date:  2022-04-01       Impact factor: 3.340

8.  Long non-coding RNA DANCR promotes cell proliferation, migration, invasion and resistance to apoptosis in esophageal cancer.

Authors:  Hui Shi; Jiahai Shi; Yudong Zhang; Chengqi Guan; Jun Zhu; Fei Wang; Mingming Xu; Qianqian Ju; Shu Fang; Maorong Jiang
Journal:  J Thorac Dis       Date:  2018-05       Impact factor: 2.895

9.  Digoxin enhances radiation response in radioresistant A549 cells by reducing protein phosphatase 2A.

Authors:  Ji Young Lee; Mi-Sook Kim; Mi So Lee; Jae Eun Ju; Namhyun Chung; Youn Kyoung Jeong
Journal:  Biosci Rep       Date:  2017-11-29       Impact factor: 3.840

10.  LINC00473 contributes to the radioresistance of esophageal squamous cell carcinoma by regulating microRNA‑497‑5p and cell division cycle 25A.

Authors:  Wei-Hua Liu; Han-Yong Qiao; Jian Xu; Wei-Qing Wang; Yi-Lei Wu; Xia Wu
Journal:  Int J Mol Med       Date:  2020-05-25       Impact factor: 4.101
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.