Literature DB >> 24524667

Prediction by pharmacogenetics of safety and efficacy of non-steroidal anti- inflammatory drugs: a review.

Victoria Rollason, Caroline Flora Samer, Youssef Daali, Jules Alexandre Desmeules1.   

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) are the most frequently used drugs, either on prescription or over-thecounter (OTC). Their daily dosage is based on randomised controlled trials and an empirical clinical assessment of their efficacy and toxicity that allows dose adjustment. The individual response can however be altered by environmental and genetic pharmacokinetic and pharmacodynamic factors. This review summarizes the available pharmacogenetic data that explains part of the variability in response and occurrence of adverse drug reactions to NSAIDs treatment, with a thorough focus on CYP2C9, uridine diphosphate glucuronosyltransferases (UGTs) and cyclooxygenases (COX1 and COX2). Other polymorphisms that are currently being studied and could also explain the interindividual variability in the efficacy and safety of NSAIDs will also be considered.

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Year:  2014        PMID： 24524667     DOI： 10.2174/1389200215666140202214454

Source DB:  PubMed          Journal:  Curr Drug Metab        ISSN： 1389-2002            Impact factor:   3.731


  10 in total

Review 1.  The role of ADME pharmacogenomics in early clinical trials: perspective of the Industry Pharmacogenomics Working Group (I-PWG).

Authors:  Larry Tremaine; William Brian; Terrye DelMonte; Stephan Francke; Peter Groenen; Keith Johnson; Lei Li; Kimberly Pearson; Jean-Claude Marshall
Journal:  Pharmacogenomics       Date:  2015-11-30       Impact factor: 2.533

2.  Activation of the transcription factor NRF2 mediates the anti-inflammatory properties of a subset of over-the-counter and prescription NSAIDs.

Authors:  Anna Eisenstein; Brandon K Hilliard; Scott D Pope; Cuiling Zhang; Pranali Taskar; Daniel A Waizman; Kavita Israni-Winger; Hui Tian; Harding H Luan; Andrew Wang
Journal:  Immunity       Date:  2022-05-18       Impact factor: 43.474

Review 3.  Impairment of aspirin antiplatelet effects by non-opioid analgesic medication.

Authors:  Amin Polzin; Thomas Hohlfeld; Malte Kelm; Tobias Zeus
Journal:  World J Cardiol       Date:  2015-07-26

4.  Efficacy of piroxicam for postoperative pain after lower third molar surgery associated with CYP2C8*3 and CYP2C9.

Authors:  Adriana Maria Calvo; Paulo Zupelari-Gonçalves; Thiago José Dionísio; Daniel Thomas Brozoski; Flávio Augusto Faria; Carlos Ferreira Santos
Journal:  J Pain Res       Date:  2017-07-06       Impact factor: 3.133

5.  Effects of FMO3 Polymorphisms on Pharmacokinetics of Sulindac in Chinese Healthy Male Volunteers.

Authors:  Yong-Jun Tang; Kai Hu; Wei-Hua Huang; Chong-Zhi Wang; Zhi Liu; Yao Chen; Dong-Sheng Ouyang; Zhi-Rong Tan; Hong-Hao Zhou; Chun-Su Yuan
Journal:  Biomed Res Int       Date:  2017-02-26       Impact factor: 3.411

Review 6.  Inflammation-Modulating Hydrogels for Osteoarthritis Cartilage Tissue Engineering.

Authors:  Rachel H Koh; Yinji Jin; Jisoo Kim; Nathaniel S Hwang
Journal:  Cells       Date:  2020-02-12       Impact factor: 6.600

7.  Inflammation (IL-1β) Modifies the Effect of Vitamin D and Omega-3 Long Chain Polyunsaturated Fatty Acids on Core Symptoms of Autism Spectrum Disorder-An Exploratory Pilot Study‡.

Authors:  Hajar Mazahery; Cathryn A Conlon; Kathryn L Beck; Owen Mugridge; Marlena C Kruger; Welma Stonehouse; Carlos A Camargo; Barbara J Meyer; Bobby Tsang; Pamela R von Hurst
Journal:  Nutrients       Date:  2020-02-28       Impact factor: 5.717

Review 8.  Analysis of Different Methods of Extracting NSAIDs in Biological Fluid Samples for LC-MS/MS Assays: Scoping Review.

Authors:  Viviane Silva Siqueira Sandrin; Gabriela Moraes Oliveira; Giovana Maria Weckwerth; Nelson Leonel Del Hierro Polanco; Flávio Augusto Cardoso Faria; Carlos Ferreira Santos; Adriana Maria Calvo
Journal:  Metabolites       Date:  2022-08-16

9.  Celastrol inhibits prostaglandin E2-induced proliferation and osteogenic differentiation of fibroblasts isolated from ankylosing spondylitis hip tissues in vitro.

Authors:  Yu-Cong Zou; Xian-Wen Yang; Shi-Guo Yuan; Pei Zhang; Yi-Kai Li
Journal:  Drug Des Devel Ther       Date:  2016-03-07       Impact factor: 4.162

10.  Evaluation of Phenotypic and Genotypic Variations of Drug Metabolising Enzymes and Transporters in Chronic Pain Patients Facing Adverse Drug Reactions or Non-Response to Analgesics: A Retrospective Study.

Authors:  Victoria Rollason; Célia Lloret-Linares; Kuntheavy Ing Lorenzini; Youssef Daali; Marianne Gex-Fabry; Valérie Piguet; Marie Besson; Caroline Samer; Jules Desmeules
Journal:  J Pers Med       Date:  2020-10-27
  10 in total

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