Baseline characteristics of depressive disorders in Thai outpatients: findings from the Thai Study of Affective Disorders.

BACKGROUND: The Thai Study of Affective Disorders was a tertiary hospital-based cohort study developed to identify treatment outcomes among depressed patients and the variables involved. In this study, we examined the baseline characteristics of these depressed patients.
METHODS: Patients were investigated at eleven psychiatric outpatient clinics at tertiary hospitals for the presence of unipolar depressive disorders, as diagnosed by the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. The severity of any depression found was measured using the Clinical Global Impression and 17-item Hamilton Depression Rating Scale (HAMD) clinician-rated tools, with the Thai Depression Inventory (a self-rated instrument) administered alongside them. Sociodemographic and psychosocial variables were collected, and quality of life was also captured using the health-related quality of life (SF-36v2), EuroQoL (EQ-5D), and visual analog scale (EQ VAS) tools.
RESULTS: A total of 371 outpatients suffering new or recurrent episodes were recruited. The mean age of the group was 45.7±15.9 (range 18-83) years, and 75% of the group was female. In terms of diagnosis, 88% had major depressive disorder, 12% had dysthymic disorder, and 50% had a combination of both major depressive disorder and dysthymic disorder. The mean (standard deviation) scores for the HAMD, Clinical Global Impression, and Thai Depression Inventory were 24.2±6.4, 4.47±1.1, and 51.51±0.2, respectively. Sixty-two percent had suicidal tendencies, while 11% had a family history of depression. Of the major depressive disorder cases, 61% had experienced a first episode. The SF-36v2 component scores ranged from 25 to 56, while the mean (standard deviation) of the EQ-5D was 0.50±0.22 and that of the EQ VAS was 53.79±21.3.
CONCLUSION: This study provides an overview of the sociodemographic and psychosocial characteristics of patients with new or recurrent episodes of unipolar depressive disorders.

Introduction

Depression causes a significant number of years of life lost due to disability in Thailand, and ranks behind only cardiovascular disorder, human immunodeficiency virus/acquired immunodeficiency syndrome, and diabetes mellitus on the disability-adjusted life year index (1999–2004).1 The Epidemiology of Mental Disorders National Survey in 2008 found major depressive disorder (MDD) in 3.2% of the Thai population, while 0.3% were found to have dysthymia (double depression was not reported).2 Despite the serious impact this disorder can have, no study has ever been published, to the authors’ knowledge, regarding treatment outcomes. Psychosocial factors usually play an important role in relation to depression, either as predisposing or precipitating elements, and so have an impact on treatment outcomes. In this study, we focused on insecure attachment (which is related to the vulnerability of an individual’s personality) and interpersonal problems among sample patients, because both are viewed as predisposing factors with respect to depression. The key precipitating factors found in this study were individual perceptions of stress and lack of social support. Prior studies have shown that insecure attachment can be related to depression, and especially fearful attachment, which has been found to be both a predictor of recurrent depression and to delay recovery.3,4 Likewise, interpersonal problems, and particularly social inhibition, have been found to be associated with depression, as has the perception of being stressed.5–7 However, the perceived level of social support received has been inconsistently related to depression in the research studies carried out; inconsistency has not only occurred with respect to depression outcomes, but also quality of life outcomes.8,9–16

Previous studies showed that quality of life was related to the severity of depression, and improvement as the symptoms subsided.17–20 Factors predicting quality of life in people suffering from acute depression include the severity of depression and economic problems, while family problems, duration of depression experienced, and its severity were found to be related to quality of life in those with chronic depression.21

To examine these associated factors and outcomes, we carried out the Thai Study of Affective Disorder (Thai-SAD), a one-year observational, collaborative, prospective cohort study of treatment outcomes in patients with MDD and/or dysthymic disorder, as well as patient quality of life. The research consisted of a multicenter study carried out at psychiatric outpatient clinics at tertiary hospitals (university and provincial hospitals) throughout Thailand, using newly diagnosed or referred cases from community hospitals and primary care settings. The purpose of this paper is to present the baseline sociodemographic and psychosocial characteristics of the study participants.

Materials and methods

Participants and procedures

A prospective, longitudinal follow-up study was carried out over the period March 2011 to August 2012 in 346 enrolled outpatients diagnosed with MDD, dysthymic disorder, or double depressive disorder, who were receiving standard treatment from a multidisciplinary team of psychiatrists, psychologists, and social workers at eleven tertiary hospitals across Thailand.

The study period lasted one year at each of the sites, although the whole study took 17 months due to the varying start times. Eligible participants were aged 18 years or older, had presented with symptoms to an outpatient clinic, and had then screened positive for depression when using the two-question (depressed mood and/or loss of interest) screening questionnaire, had experienced a first episode of MDD or recurrent episodes, and/or recurrent episodes of dysthymia or double depression. Exclusion criteria were: comorbidity, pregnancy, and lactation; severe substance abuse; cognitive impairment on Mini-Mental Status Examination; a history of schizophrenia or bipolar disorder; and failure to provide written informed consent.

At baseline, the participants were diagnosed as having MDD and/or dysthymic disorder according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR) using the Mini International Neuropsychiatric Inventory (MINI),22,23 and were also assessed for depression by trained clinicians and psychiatric investigators. Demographic data and psychosocial variables, as reported by the participants, were then collected by research assistants. The participants were followed up at 3-month intervals over a one-year period (five assessments, including baseline). The 17-item Hamilton Depression Rating Scale (HAMD-17) and Clinical Global Impression (CGI) were evaluated by investigators at each visit; however, a complete set of measurements (all using clinician-rated and self-reporting questionnaires) was carried out three times; first at baseline, the second time at visit 3, and the third time at visit 5.

Of the 3,167 outpatients being treated for MDD across all eleven hospitals at the time of the study, 371 (11.7%) cases with a new episode or recurrent episodes of unipolar MDD, dysthymic disorder, and/or double depression gave their consent and were recruited. Twenty-five of these potential participants were excluded due to the presence of comorbidity, meaning the final study included 346 patients.

Instruments

The clinician-rated measurement tools used included the Clinical Global Impression-Severity scale (CGI-S), a seven-point scale that requires clinicians to rate severity of illness (1, normal; 7, extremely ill). The severity of depression was assessed using the HAMD-17, plus a self-reporting depression scale which included the Thai Depression Inventory (TDI), a 20-item, four-rating scale which assesses the severity of depressive symptoms (1, most severe; 4, normal). The TDI was used for patients aged 18–59 years. The Thai versions of the HAMD and TDI demonstrate good reliability and validity.24,25 The Thai version of the Geriatric Depression Scale, a 30-item, true-false type assessment of depressive symptoms, was also used for participants aged ≥60 years, and has also demonstrated good reliability and validity.26

Additional outcome measures included those related to quality of life. The 36-item health-related quality of life (SF-36v2) tool was used to elicit eight quality of life components, including general health, physical functioning, role-physical, role-emotional, social functioning, bodily pain, vitality, and mental health, as was the EuroQoL-5 Dimension (EQ-5D), a five-item standardized questionnaire used to assess five quality of life aspects, these being mobility, self-care, usual activities, pain/discomfort, and anxiety/depression. The Thai version has demonstrated good reliability. In addition to the EQ-5D descriptive system, respondents rated their health at the time using a visual analog scale (EQ VAS) ranging from 0 (worst imaginable health state) to 100 (best imaginable health state). The Thai version of the EQ-5D has been validated in the general Thai population.27,28

The psychosocial measurement tools used included the 32-item Inventory of Interpersonal Problems scale, which uses a 5-Likert scale to assess the severity of eight aspects of interpersonal problems experienced throughout the participants’ daily lives. These interpersonal problems include dominance, vindictiveness, cold, social inhibition, nonassertiveness, over-accommodation, self-sacrifice, and intrusion. The Thai version of the 32-item Inventory of Interpersonal Problems scale has demonstrated good reliability and validity.29 Secure and insecure attachment were assessed using the short version of the Revised-Experience of Close Relationships scale, a 18-item, 7-Likert scale tool which assesses how much anxiety (ie, attachment anxiety) or how close the respondent feels towards a partner or person close to them (ie, attachment avoidance). High attachment anxiety and/or high attachment avoidance is considered to reflect insecure attachment. The Thai version of the Revised-Experience of Close Relationships scale has also demonstrated good reliability and validity.29,30 Also used were the Perceived Stress Scale (PSS), a 10-item scale, 5-Likert scale tool which records how frequently people feel stressed, and the Multi-dimensional Scale of Perceived Social Support (MSPSS), a 12-item, 7-Likert scale self-reporting tool which records how much social support respondents require. The Thai versions of the PSS and MSPSS have demonstrated good reliability and validity.31–33

Statistical analysis

For the continuous variables, the mean ± standard deviations (SD) and median with range were used, whereas categorical data were presented as the number and percentage. The statistical significance level for all the tests was set at a P-value <0.05, and Statistical Package for the Social Sciences version 17 software (SPSS Inc., Chicago, IL, USA) was used to perform all the analyses.

Results

Table 1 shows that the mean ± SD participant age was 45.7±15.9 (range 18–83) years. Seventy-five percent of respondents were female, and 42 (12.1%) had been educated to elementary school level or less. In terms of marital status, 109 (32.3%) were single, while for employment status, most were employed (75.7%). Two hundred and four (62.2%) earned no more than 10,000 baht (US$300) per month, while 39.9% earned less than 5,000 baht (US$166.7). Two hundred and twenty-six (79.4%) had government-related health insurance.

Table 1

Baseline characteristics of respondents with depression

Sociodemographic variables (n=346)	Value n (%) or mean (SD)
Sex
Male	87 (25.14)
Female	259 (74.56)
Age (years)
18–30	74 (21.4)
31–45	101 (29.2)
46–59	106 (30.6)
≥60	65 (18.8)
Mean (SD)	45.7 (15.9)
Median (range)	45 (18–83)
Education
Below elementary	42 (12.1)
Elementary to junior high school	105 (30.3)
High school	79 (22.8)
Bachelor degree or higher	120 (34.7)
Marital status
Single	109 (31.5)
Married	154 (45.5)
Widowed/divorced	83 (24.0)
Employment
Employed	262 (75.7)
Unemployed	84 (24.3)
Income (baht)
<5,000	131 (37.9)
5,001–10,000	73 (21.1)
10,001–20,000	65 (18.8)
>20,000	59 (22.2)
Health care delivery system used
Self-financed	69 (19.9)
Civil servant medical benefits scheme	100 (28.9)
Social security scheme	50 (14.5)
Universal coverage scheme	127 (36.7)
Depression
MDD (both first episode and recurrent)	306 (88.4)
Dysthymic disorder	22 (6.4)
Double depression	18 (5.2)
MDD (n=306)
First episode	188 (61.4)
Recurrent episodes	118 (38.6)
MDD with psychotic symptoms	15 (4.3)
MDD with melancholic symptoms	124 (35.8)
Suicidality present (n=332)
Yes	207 (62.3)
No	125 (37.7)
Severity of suicidality
Mild (score 1–5)	98 (48.3)
Moderate (score 6–9)	34 (16.7)
Severe (score ≥10)	71 (35.0)
Measurement of depression
HAMD-17
Total mean (SD)	24.20 (6.4)
(Range)	(10–43)
MDD (n=306)	24.40 (6.6)
Dysthymic disorder (n=22)	19.90 (6.4)
Double depression (n=18)	25.06 (4.6)
Thai Depression inventory (n=272)	51.51 (10.2)
(Range)	(28–80)
Geriatric Depression Scale (n=74)	17.77 (6.8)
(Range)	(3–29)
CGI-S
Mean (SD)	4.47 (1.1)
Median (range)	5.0 (2.0–7.0)
History of suicide attempts (n=302)
Yes	80 (26.5)
No	222 (73.5)
Family history of psychiatric disorders (n=328)
Yes	96 (29.2)
No	232 (70.8)
Family history
Depression	35 (10.7)
Bipolar disorder	5 (1.5)
Cognitive disorder	4 (1.2)
Alcohol and substance disorders	8 (2.3)
Other (schizophrenia, autism, anxiety disorders)	42 (12.8)

Abbreviations: CGI-S, Clinical Global Impression of Severity; MDD, major depressive disorder; SD, standard deviation; HAMD-17, 17-item Hamilton Depression Rating Scale.

With respect to the diagnoses, MDD was diagnosed in 88.4% of the sample, with 61.4% having a first episode of MDD. Nearly 12% of the group was suffering from dysthymic disorder, while nearly 50% had superimposed MDD (double depression). The mean ± SD scores on the HAMD for MDD, dysthymic disorder, and double depression were 24.20±6.4, 19.90±6.4, and 25.06±4.6, respectively.

The mean ± SD CGI score was 4.47±1.1. There was a high incidence of suicidality found in 207 of the group (62.3%), with 51.7% suffering a moderate to severe level. Eighty respondents (26.5%) had a history of suicide attempts, whereas 29.2% had a family history of a psychiatric disorder. Among those with a family history of a psychiatric disorder, a history of depression was prevalent (10.7%).

In terms of psychosocial factors, the mean ± SD for the 32-item Inventory of Interpersonal Problems scale, attachment anxiety, attachment avoidance, PSS, and MSPSS was 65.8±13.3, 3.72±1.6, 3.88±1.1, 19.22±5.3, and 4.38±1.3, respectively. The percentage of those demonstrating secure attachment was higher than for insecure attachment (80.6% versus 19.4%).

For quality of life, the subscale scores using the SF-36v2 ranged from 25.35 to 55.60. The subscale for general health received the lowest score (25.35±18.20), while physical role received the highest score (55.60±28.3).

The mean score generated by the EQ-5D tool for the total sample was 0.502±0.22, and this corresponded with the mean score produced by the EQ VAS, which was 50.86±21.5, reflecting a moderate quality of life score (Table 2).

Table 2

Psychosocial variables and quality of life components

	Value n (%) or mean (SD)
Psychosocial variables (n=346)
Interpersonal problems	65.82 (13.3)
(Range)	(25–105)
Attachment anxiety	3.72 (1.6)
(Range)	(1–7)
Attachment avoidance	3.88 (1.1)
(Range)	(1–7)
Insecure attachment (n=325)
Yes	63 (19.4)
No	262 (80.6)
Perceived stress	19.22 (5.3)
(Range)	(2–32)
Multidimensional scale for social support	4.38 (1.3)
(Range)	(1–7)
Quality of life (n=346)
SF-36v2
General health	25.35 (18.20)
(Range)	(0–84.80)
Physical functioning	53.34 (29.3)
(Range)	(0–100)
Role-physical	55.60 (28.3)
(Range)	(0–100)
Role-emotional	49.28 (27.2)
(Range)	(0–100)
Social functioning	51.29 (25.2)
(Range)	(0–100)
Bodily pain	50.22 (27.5)
(Range)	(0–100)
Vitality	30.88 (19.0)
(Range)	(0–94)
Mental health	34.49 (18.0)
(Range)	(0–95)
EQ-5D	0.502 (0.22)
(Range)	(−0.33 to 1.00)
EQ VAS	50.86 (21.5)
(Range)	(0–100)

Abbreviations: EQ-5D, EuroQoL-5 Dimension descriptive system; EQ VAS, EuroQoL visual analog scale; SD, standard deviation; SF-36v2, 36-item health-related quality of life tool.

Discussion

As found in other studies, women sought treatment for depression more readily than men. For example, in a Canadian and US national survey, the ratio of females to males seeking treatment was 1.64–1.67:1, which is consistent with a previous national survey in Thailand where the ratio was 1.6:1.2,34,35 However, for our study, carried out in a university or provincial hospital setting, this ratio rose to 2.97:1, when hospitals are considered tertiary care settings where patients can access treatment either directly or via referral. This figure is similar to that reported for South Korea by Kim et al, who found a ratio of 2.91:1.36 This may be due to the fact that depressed Asian men are less likely to seek help than depressed Asian women.37–39 In addition, when comparing our age group results with those in that study, we found a similarly high proportion of elderly patients, ie, 18.8% (14.5% over 65 years of age) as compared with 16.7% (aged 65 years and over) in South Korea. The ratio found for this age group was, therefore, higher in this study than in previous Thai studies.

In terms of the distribution of diagnoses, the rate of dysthymia in our study was quite low when compared with other studies, even though it was found to be higher than in the national survey (11.5% versus 8.8% in the national survey),2 which may be due to the poor validity of the Thai MINI instrument with regard to diagnosis of dysthymia (Cohen’s kappa only 0.2).23 In terms of future research, another instrument, such as the Structured Clinical Interview for DSM-IV Axis I Disorders dysthymia module, may be added to the MINI to ensure a better dysthymia diagnosis.

With respect to past history of suicide attempts, our study produced similar results to those of the South Korean study (26% versus 21%, respectively),36 both of which are higher scores than those recorded by Claassen et al in the USA (16.5%).40 The rate of recurrent suicidality episodes was found to be higher in our study than in the 2008 national survey in Thailand,2 which was carried out in a primary care setting (and for which the results were 2.4% for the current rate and 0.7% for the recurrent rate).2 This may have been because our research settings were university hospitals, to which patients are often referred from primary care or secondary care hospitals.

In addition, the impact of a family history of depression was found to be similar to that in the study by Kim et al (10% versus 13.8%, respectively), but dissimilar to the Western research undertaken by Nierenberg et al (55.6%)41 and Yang et al (25%–33%).42 It is difficult to draw definitive conclusions from these results; however, we speculate that this discrepancy may reflect the questionnaire used. Family history in the Thai-SAD was assessed using a single question and noncategorized subjects (parents or parents of first-degree family members), which may have limited the reliability of the data when compared with the studies by Nierenberg et al and Yang et al.

As expected, the interpersonal problems’ scores in the studied sample were high. This study highlights the association between depression and interpersonal problems, that is commonly found and which, in turn, may make them vulnerable to depression.5,43 At the same time, the PSS scores were higher for the depressed patients in this study than for the normal and nondepressed clinical samples in our previous study31 (19.15±5.3, 13.53±4.56, and 13.99±4.27, respectively), while patients felt they were receiving less support than normal respondents (5.79±1.0 versus 4.35±1.3, respectively).32 Our sample also showed a higher rate of insecure attachment based on the Revised-Experience of Close Relationships score than the normal population and general psychiatric outpatients.30 With regard to health-related quality of life, the depressed patients were found to have a poorer quality of life than those who were not depressed, the difference here also being dependent on the severity of depression.44

Other researchers have found that depression, in particular somatic depression, is associated with high rates of pain and anxiety (a specific type of anxious somatic depression), and is most commonly found in women.34,45

When using the EQ-5D tool, depressed patients were found to have an overall moderate quality of life score, which is consistent with the results obtained using the EQ VAS and SF-36v2. It is important to note that quality of life in this Thai sample was found to be lower among depressed patients than in other studies.45,46 Further research is needed in order to examine this finding in more detail.

Our study has some strengths, in that it was a multicenter study of a “real-life” cohort of depressed patients and all sociodemographic, clinical, and psychosocial variables were assessed. However, the study also has some limitations. First, its design meant that there were inevitable problems related to missing data. Second, there are no standard treatment guidelines available for depression in Thailand, plus antidepressant drugs used at sites are different, depending on the health care delivery system provided of each site. This limits the level of homogeneity in terms of the practice guidelines used.

Conclusion

Thai-SAD provides sociodemographic and psychosocial data for a group of Thais experiencing new or recurrent episodes of unipolar depression. The unique aspect of this study is that it collected data regarding psychosocial variables, which may act as predictors for recurrence or relapse of depression. Some psychosocial variables, eg, a high perception of stress score, may predict a relapse. Firm conclusions cannot be reached as yet; however, because the complete data set is not yet available, the data here represents a baseline. Our intention is to address this shortfall in a subsequent study.