Literature DB >> 24519184

Are multiple platelet-rich plasma injections useful for treatment of chronic patellar tendinopathy in athletes? a prospective study.

Christophe Charousset1, Amine Zaoui, Laurence Bellaiche, Benjamin Bouyer.   

Abstract

BACKGROUND: Chronic patellar tendinopathy (PT) is one of the most common overuse knee disorders. Platelet-rich plasma (PRP) appears to be a reliable nonoperative therapy for chronic PT.
PURPOSE: To evaluate clinical and radiological outcomes of 3 consecutive ultrasound (US)-guided PRP injections for the treatment of chronic PT in athletes. STUDY
DESIGN: Case series; Level of evidence, 4.
METHODS: A total of 28 athletes (17 professional, 11 semiprofessional) with chronic PT refractory to nonoperative management were prospectively included for US-guided pure PRP injections into the site of the tendinopathy. The same treating physician at a single institution performed 3 consecutive injections 1 week apart, with the same PRP preparation used. All patients underwent clinical evaluation, including the Victorian Institute of Sport Assessment-Patella (VISA-P) score, visual analog scales (VAS) for pain, and Lysholm knee scale before surgery and after return to practice sports. Tendon healing was assessed with MRI at 1 and 3 months after the procedure.
RESULTS: The VISA-P, VAS, and Lysholm scores all significantly improved at the 2-year follow-up. The average preprocedure VISA-P, VAS, and Lysholm scores improved from 39 to 94 (P < .001), 7 to 0.8 (P < .0001), and 60 to 96 (P < .001), respectively, at the 2-year follow-up. Twenty-one of the 28 athletes returned to their presymptom sporting level at 3 months (range, 2-6 months) after the procedure. Follow-up MRI assessment showed improved structural integrity of the tendon at 3 months after the procedure and complete return to normal structural integrity of the tendon in 16 patients (57%). Seven patients did not recover their presymptom sporting level (among them, 6 were considered treatment failures): 3 patients returned to sport at a lesser level, 1 patient changed his sport activity (for other reasons), and 3 needed surgical intervention.
CONCLUSION: In this study, application of 3 consecutive US-guided PRP injections significantly improved symptoms and function in athletes with chronic PT and allowed fast recovery to their presymptom sporting level. The PRP treatment permitted a return to a normal architecture of the tendon as assessed by MRI.

Entities:  

Keywords:  jumper’s knee; patellar tendinopathy; platelet-rich plasma; treatment

Mesh:

Year:  2014        PMID: 24519184     DOI: 10.1177/0363546513519964

Source DB:  PubMed          Journal:  Am J Sports Med        ISSN: 0363-5465            Impact factor:   6.202


  22 in total

Review 1.  Myths and Facts of In-Office Regenerative Procedures for Tendinopathy.

Authors:  Alyssa Neph; Kentaro Onishi; James H-C Wang
Journal:  Am J Phys Med Rehabil       Date:  2019-06       Impact factor: 2.159

Review 2.  Platelet-rich plasma: evidence for the treatment of patellar and Achilles tendinopathy--a systematic review.

Authors:  B Di Matteo; G Filardo; E Kon; M Marcacci
Journal:  Musculoskelet Surg       Date:  2014-10-17

Review 3.  Platelet-rich plasma in tendon-related disorders: results and indications.

Authors:  Giuseppe Filardo; Berardo Di Matteo; Elizaveta Kon; Giulia Merli; Maurilio Marcacci
Journal:  Knee Surg Sports Traumatol Arthrosc       Date:  2016-09-24       Impact factor: 4.342

4.  Description of a standardized rehabilitation program based on sub-maximal eccentric following a platelet-rich plasma infiltration for jumper's knee.

Authors:  Jean-François Kaux; Bénédicte Forthomme; Marie-Hélène Namurois; Philippe Bauvir; Nathalie Defawe; François Delvaux; Cédric Lehance; Jean-Michel Crielaard; Jean-Louis Croisier
Journal:  Muscles Ligaments Tendons J       Date:  2014-05-08

5.  Platelet-rich plasma as a treatment for chronic patellar tendinopathy: comparison of a single versus two consecutive injections.

Authors:  Rachad Zayni; Mathieu Thaunat; Jean-Marie Fayard; Jean-Philippe Hager; Yannick Carrillon; Julien Clechet; François Gadea; Pooler Archbold; Bertrand Sonnery Cottet
Journal:  Muscles Ligaments Tendons J       Date:  2015-07-03

Review 6.  Role of Alpha-2-Microglobulin in the Treatment of Osteoarthritic Knee Pain: a Brief Review of the Literature.

Authors:  Vwaire Orhurhu; Ruben Schwartz; Jacob Potts; Jacqueline Peck; Ivan Urits; Mariam Salisu Orhurhu; Charles Odonkor; Omar Viswanath; Alan Kaye; Jatinder Gill
Journal:  Curr Pain Headache Rep       Date:  2019-09-09

7.  PAST, CURRENT AND FUTURE INTERVENTIONAL ORTHOBIOLOGICS TECHNIQUES AND HOW THEY RELATE TO REGENERATIVE REHABILITATION: A CLINICAL COMMENTARY.

Authors:  Christopher J Centeno; Sarah M Pastoriza
Journal:  Int J Sports Phys Ther       Date:  2020-04

8.  Infiltration of Autologous Growth Factors in Chronic Tendinopathies.

Authors:  Antonio Crescibene; Marcello Napolitano; Raffaella Sbano; Enrico Costabile; Hesham Almolla
Journal:  J Blood Transfus       Date:  2015-06-15

Review 9.  Clinical applications of platelet-rich plasma in patellar tendinopathy.

Authors:  D U Jeong; C-R Lee; J H Lee; J Pak; L-W Kang; B C Jeong; S H Lee
Journal:  Biomed Res Int       Date:  2014-07-21       Impact factor: 3.411

10.  Cytokine-release kinetics of platelet-rich plasma according to various activation protocols.

Authors:  Y H Roh; W Kim; K U Park; J H Oh
Journal:  Bone Joint Res       Date:  2016-02       Impact factor: 5.853

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