Vwaire Orhurhu1, Ruben Schwartz2, Jacob Potts3, Jacqueline Peck2, Ivan Urits4, Mariam Salisu Orhurhu5, Charles Odonkor6, Omar Viswanath7,8,9, Alan Kaye10, Jatinder Gill4. 1. Department of Anesthesia, Critical Care, and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA, 02215, USA. Vwo569@mail.harvard.edu. 2. Department of Anesthesiology, Mount Sinai Medical Center of Florida, Miami, FL, USA. 3. Department of Bioengineering, Northeastern University, Boston, MA, USA. 4. Department of Anesthesia, Critical Care, and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA, 02215, USA. 5. Departments of Anesthesiology and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA. 6. Department of Anesthesia, Critical Care and Pain Medicine, Division of Pain, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. 7. Valley Anesthesiology and Pain Consultants, Phoenix, AZ, USA. 8. Department of Anesthesiology, University of Arizona College of Medicine-Phoenix, Phoenix, AZ, USA. 9. Department of Anesthesiology, Creighton University School of Medicine, Omaha, NE, USA. 10. Department of Anesthesiology, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
Abstract
PURPOSE OF REVIEW: Chronic knee pain remains a debilitating condition that remains difficult to manage. The purpose of this review, therefore, is to summarize current understanding of alpha-2-microglobulin in the treatment of osteoarthritic knee pain. Furthermore, we investigate its role in the anti-inflammatory properties of platelet-rich plasma (PRP). RECENT FINDINGS: Alpha-2-microglobulin, a 720-kD protein complex, is an active protease inhibitor with tremendous anti-inflammatory properties in animal models. A growing body of evidence suggests that this complex is the most instrumental factor for cartilage preservation in PRP injections. As an active component of platelet-rich plasma's anti-inflammatory properties, alpha-2-microglobulin has been shown to be an active inhibitor of joint degeneration, cartilage preservation, and improvement in quality of life for patients with knee osteoarthritis compared with a multitude of other modalities.
PURPOSE OF REVIEW: Chronic knee pain remains a debilitating condition that remains difficult to manage. The purpose of this review, therefore, is to summarize current understanding of alpha-2-microglobulin in the treatment of osteoarthritic knee pain. Furthermore, we investigate its role in the anti-inflammatory properties of platelet-rich plasma (PRP). RECENT FINDINGS: Alpha-2-microglobulin, a 720-kD protein complex, is an active protease inhibitor with tremendous anti-inflammatory properties in animal models. A growing body of evidence suggests that this complex is the most instrumental factor for cartilage preservation in PRP injections. As an active component of platelet-rich plasma's anti-inflammatory properties, alpha-2-microglobulin has been shown to be an active inhibitor of joint degeneration, cartilage preservation, and improvement in quality of life for patients with knee osteoarthritis compared with a multitude of other modalities.
Authors: Gaetano J Scuderi; S Raymond Golish; Frank F Cook; Jason M Cuellar; Robert P Bowser; Lewis S Hanna Journal: J Bone Joint Surg Am Date: 2011-02-16 Impact factor: 5.284
Authors: Femke Intema; Peter M Van Roermund; Anne C A Marijnissen; Sebastian Cotofana; Felix Eckstein; Rene M Castelein; Johannes W J Bijlsma; Simon C Mastbergen; Floris P J G Lafeber Journal: Ann Rheum Dis Date: 2011-05-12 Impact factor: 19.103
Authors: Adam G Culvenor; Britt Elin Øiestad; Harvi F Hart; Joshua J Stefanik; Ali Guermazi; Kay M Crossley Journal: Br J Sports Med Date: 2018-06-09 Impact factor: 13.800