Literature DB >> 2451707

VH gene family utilization is regulated by a locus outside of the VH region.

G E Wu1, C J Paige.   

Abstract

We have used the RNA colony blot method to examine VH usage in colonies derived from primary splenic B cells. We found that there are strain-specific differences in the pattern of VH usage. Using parental F1, congenic, and recombinant inbred strains we demonstrate that the genetic element that causes the observed phenotype is: (a) stably expressed; (b) not due to maternal influence; (c) not due to dominate diffusible factors; (d) not linked to cloning efficiency; and (e) outside the Igh locus.

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Year:  1988        PMID： 2451707      PMCID： PMC2188925          DOI： 10.1084/jem.167.4.1499

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  10 in total

1.  Detection of RNA transcripts in normal lymphoid and myeloid colonies.

Authors:  C J Paige; G E Wu; C L Castiglia
Journal:  J Immunol Methods       Date:  1986-10-23       Impact factor: 2.303

2.  Developmentally controlled and tissue-specific expression of unrearranged VH gene segments.

Authors:  G D Yancopoulos; F W Alt
Journal:  Cell       Date:  1985-02       Impact factor: 41.582

3.  One heavy chain variable region gene segment subfamily in the BALB/c mouse contains 500-1000 or more members.

Authors:  D Livant; C Blatt; L Hood
Journal:  Cell       Date:  1986-11-07       Impact factor: 41.582

4.  Extrachromosomal DNA substrates in pre-B cells undergo inversion or deletion at immunoglobulin V-(D)-J joining signals.

Authors:  J E Hesse; M R Lieber; M Gellert; K Mizuuchi
Journal:  Cell       Date:  1987-06-19       Impact factor: 41.582

5.  Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines.

Authors:  G D Yancopoulos; S V Desiderio; M Paskind; J F Kearney; D Baltimore; F W Alt
Journal:  Nature       Date:  1984 Oct 25-31       Impact factor: 49.962

Review 6.  Somatic generation of antibody diversity.

Authors:  S Tonegawa
Journal:  Nature       Date:  1983-04-14       Impact factor: 49.962

7.  The immunoglobulin heavy chain variable region (Igh-V) locus in the mouse. I. One hundred Igh-V genes comprise seven families of homologous genes.

Authors:  P H Brodeur; R Riblet
Journal:  Eur J Immunol       Date:  1984-10       Impact factor: 5.532

8.  Organization of the murine immunoglobulin VH complex in the inbred strains.

Authors:  G A Rathbun; J D Capra; P W Tucker
Journal:  EMBO J       Date:  1987-10       Impact factor: 11.598

9.  Genotypic analysis of B cell colonies by in situ hybridization. Stoichiometric expression of three VH families in adult C57BL/6 and BALB/c mice.

Authors:  D H Schulze; G Kelsoe
Journal:  J Exp Med       Date:  1987-07-01       Impact factor: 14.307

10.  VH gene family utilization in colonies derived from B and pre-B cells detected by the RNA colony blot assay.

Authors:  G E Wu; C J Paige
Journal:  EMBO J       Date:  1986-12-20       Impact factor: 11.598
  10 in total
  10 in total

1.  A deletion map of the human immunoglobulin heavy chain variable region.

Authors:  M A Walter; H M Dosch; D W Cox
Journal:  J Exp Med       Date:  1991-08-01       Impact factor: 14.307

2.  Normal serum immunoglobulins participate in the selection of peripheral B-cell repertoires.

Authors:  A A Freitas; A C Viale; A Sundblad; C Heusser; A Coutinho
Journal:  Proc Natl Acad Sci U S A       Date:  1991-07-01       Impact factor: 11.205

3.  Infrequent utilization of the immunoglobulin heavy chain variable region(s) identical or closely related to that of MOPC315 myeloma protein in the functional V region formation in B-precursor cell lines.

Authors:  H Sugiyama; Y Minami; T Komori; N Sakato; S Kishimoto
Journal:  Immunology       Date:  1989-12       Impact factor: 7.397

4.  Altered phenotypic expression of immunoglobulin heavy-chain variable-region (VH) genes in Alicia rabbits probably reflects a small deletion in the VH genes closest to the joining region.

Authors:  M Allegrucci; B A Newman; G O Young-Cooper; C B Alexander; D Meier; A S Kelus; R G Mage
Journal:  Proc Natl Acad Sci U S A       Date:  1990-07       Impact factor: 11.205

5.  The physical organization of the human immunoglobulin heavy chain gene complex.

Authors:  M A Walter; U Surti; M H Hofker; D W Cox
Journal:  EMBO J       Date:  1990-10       Impact factor: 11.598

6.  The genomic organization of immunoglobulin VH genes in Xenopus laevis shows evidence for interspersion of families.

Authors:  R N Haire; Y Ohta; R T Litman; C T Amemiya; G W Litman
Journal:  Nucleic Acids Res       Date:  1991-06-11       Impact factor: 16.971

7.  Molecular cloning of the primary IgH repertoire: a quantitative analysis of VH gene usage in adult mice.

Authors:  K M Sheehan; P H Brodeur
Journal:  EMBO J       Date:  1989-08       Impact factor: 11.598

8.  The organization of the mouse Igh-V locus. Dispersion, interspersion, and the evolution of VH gene family clusters.

Authors:  P H Brodeur; G E Osman; J J Mackle; T M Lalor
Journal:  J Exp Med       Date:  1988-12-01       Impact factor: 14.307

9.  Differential expression of VH gene families in peripheral B cell repertoires of newborn or adult immunoglobulin H chain congenic mice.

Authors:  A C Viale; A Coutinho; A A Freitas
Journal:  J Exp Med       Date:  1992-06-01       Impact factor: 14.307

10.  Biased expression of JH-proximal VH genes occurs in the newly generated repertoire of neonatal and adult mice.

Authors:  B A Malynn; G D Yancopoulos; J E Barth; C A Bona; F W Alt
Journal:  J Exp Med       Date:  1990-03-01       Impact factor: 14.307
  10 in total

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