Elena Kostova1, Maja Slaninka-Miceska2, Nikola Labacevski2, Krume Jakovski2, Jasmina Trojachanec2, Emilija Atanasovska2, Vlado Janevski3, Rubens Jovanovik4, Vesna Janevska4. 1. Department of Preclinical and Clinical Pharmacology and Toxicology, Faculty of Medicine, Ss. Cyril and Methodius University, Skopje, Republic of Macedonia. eli_kos_pet@yahoo.com 2. Department of Preclinical and Clinical Pharmacology and Toxicology, Faculty of Medicine, Ss. Cyril and Methodius University, Skopje, Republic of Macedonia. 3. Digestive Surgery Clinic, Faculty of Medicine, Ss. Cyril and Methodius University, Skopje, Republic of Macedonia. 4. Department of Pathology, Faculty of Medicine, Ss. Cyril and Methodius University, Skopje, Republic of Macedonia.
Abstract
BACKGROUND/AIM: Matrix metalloproteinases (MMPs) are perceived to play a key role in tumor invasion and metastasis by their capacity to degrade basement membranes and extracellular matrix proteins. The aim of this study was to investigate the expressions of MMP-2, MMP-7 and MMP-9 in tumor tissue and their relation to clinicopathologic features in patients with colorectal cancer. METHODS: Specimens of resected colorectal cancer and surrounding normal tissue of 82 patients were immunohistochemically stained for MMP-2, MMP-7 and MMP-9. The results of immunohistochemical expression of MMPs were correlated with some clinical and pathologic parameters. RESULTS: Immunohistochemical expression of MMP-2 was more frequent in the patients with higher preoperative serum levels of carcinoembryonic antigen (CEA) (p = 0.047), MMP-2 (p = 0.018), MMP-9 (p = 0.036) and in those with lymph node metastasis (p = 0.018) and the advanced stage of the disease (p = 0.046). Expression of MMP-7 was more frequent in the patients with elevated preoperative serum levels of: CEA (p = 0.012), MMP-7 (p = 0.036), MMP-9 (p = 0.023) and with deeply invasive neoplasms (p = 0.027). MMP-9 cell expression was in a positive correlation with elevated preoperative serum levels of: CEA (p = 0.013), MMP-2 (p = 0.012), MMP-9 (p = 0.018) and depth of CRC invasion, ie T-parameter (p = 0.027). CONCLUSION: Immunohistochemical expression of MMPs is a useful indicator of the disease development and progression in patients with colorectal cancer.
BACKGROUND/AIM: Matrix metalloproteinases (MMPs) are perceived to play a key role in tumor invasion and metastasis by their capacity to degrade basement membranes and extracellular matrix proteins. The aim of this study was to investigate the expressions of MMP-2, MMP-7 and MMP-9 in tumor tissue and their relation to clinicopathologic features in patients with colorectal cancer. METHODS: Specimens of resected colorectal cancer and surrounding normal tissue of 82 patients were immunohistochemically stained for MMP-2, MMP-7 and MMP-9. The results of immunohistochemical expression of MMPs were correlated with some clinical and pathologic parameters. RESULTS: Immunohistochemical expression of MMP-2 was more frequent in the patients with higher preoperative serum levels of carcinoembryonic antigen (CEA) (p = 0.047), MMP-2 (p = 0.018), MMP-9 (p = 0.036) and in those with lymph node metastasis (p = 0.018) and the advanced stage of the disease (p = 0.046). Expression of MMP-7 was more frequent in the patients with elevated preoperative serum levels of: CEA (p = 0.012), MMP-7 (p = 0.036), MMP-9 (p = 0.023) and with deeply invasive neoplasms (p = 0.027). MMP-9 cell expression was in a positive correlation with elevated preoperative serum levels of: CEA (p = 0.013), MMP-2 (p = 0.012), MMP-9 (p = 0.018) and depth of CRC invasion, ie T-parameter (p = 0.027). CONCLUSION: Immunohistochemical expression of MMPs is a useful indicator of the disease development and progression in patients with colorectal cancer.
Authors: Jung Chun Liao; Kun Tsung Lee; Bang Jau You; Chia Lin Lee; Wen Te Chang; Yang Chang Wu; Hong-Zin Lee Journal: Food Nutr Res Date: 2015-12-22 Impact factor: 3.894
Authors: Thao Phuong Bui; Anh Ngoc Hoang; Phuong Lan Le; Bich Thi Pham; Linh Thi Tu Nguyen; Ha Minh Do; To Van Ta; Thai Hong Trinh Journal: Oncol Lett Date: 2017-02-06 Impact factor: 2.967