Literature DB >> 24515294

Ca handling during excitation-contraction coupling in heart failure.

Aleksey V Zima1, Elisa Bovo, Stefan R Mazurek, Jennifer A Rochira, Weiyan Li, Dmitry Terentyev.   

Abstract

In the heart, coupling between excitation of the surface membrane and activation of contractile apparatus is mediated by Ca released from the sarcoplasmic reticulum (SR). Several components of Ca machinery are perfectly arranged within the SR network and the T-tubular system to generate a regular Ca cycling and thereby rhythmic beating activity of the heart. Among these components, ryanodine receptor (RyR) and SR Ca ATPase (SERCA) complexes play a particularly important role and their dysfunction largely underlies abnormal Ca homeostasis in diseased hearts such as in heart failure. The abnormalities in Ca regulation occur at practically all main steps of Ca cycling in the failing heart, including activation and termination of SR Ca release, diastolic SR Ca leak, and SR Ca uptake. The contributions of these different mechanisms to depressed contractile function and enhanced arrhythmogenesis may vary in different HF models. This brief review will therefore focus on modifications in RyR and SERCA structure that occur in the failing heart and how these molecular modifications affect SR Ca regulation and excitation-contraction coupling.

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Year:  2014        PMID： 24515294      PMCID： PMC5370565          DOI： 10.1007/s00424-014-1469-3

Source DB:  PubMed          Journal:  Pflugers Arch        ISSN： 0031-6768            Impact factor:   3.657


  116 in total

1.  PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts.

Authors:  S O Marx; S Reiken; Y Hisamatsu; T Jayaraman; D Burkhoff; N Rosemblit; A R Marks
Journal:  Cell       Date:  2000-05-12       Impact factor: 41.582

2.  Quantitative assessment of the SR Ca2+ leak-load relationship.

Authors:  Thomas R Shannon; Kenneth S Ginsburg; Donald M Bers
Journal:  Circ Res       Date:  2002-10-04       Impact factor: 17.367

3.  Hyperphosphorylation of the cardiac ryanodine receptor at serine 2808 is not involved in cardiac dysfunction after myocardial infarction.

Authors:  Hongyu Zhang; Catherine A Makarewich; Hajime Kubo; Wei Wang; Jason M Duran; Ying Li; Remus M Berretta; Walter J Koch; Xiongwen Chen; Erhe Gao; Héctor H Valdivia; Steven R Houser
Journal:  Circ Res       Date:  2012-02-02       Impact factor: 17.367

4.  Ryanodine receptor phosphorylation and heart failure: phasing out S2808 and "criminalizing" S2814.

Authors:  Héctor H Valdivia
Journal:  Circ Res       Date:  2012-05-25       Impact factor: 17.367

5.  Abnormal Ca2+ release, but normal ryanodine receptors, in canine and human heart failure.

Authors:  Ming Tao Jiang; Andrew J Lokuta; Emily F Farrell; Matthew R Wolff; Robert A Haworth; Héctor H Valdivia
Journal:  Circ Res       Date:  2002-11-29       Impact factor: 17.367

6.  Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression.

Authors:  Xander H T Wehrens; Stephan E Lehnart; Steven Reiken; John A Vest; Anetta Wronska; Andrew R Marks
Journal:  Proc Natl Acad Sci U S A       Date:  2006-01-06       Impact factor: 11.205

7.  Shortened Ca2+ signaling refractoriness underlies cellular arrhythmogenesis in a postinfarction model of sudden cardiac death.

Authors:  Andriy E Belevych; Dmitry Terentyev; Radmila Terentyeva; Hsiang-Ting Ho; Inna Gyorke; Ingrid M Bonilla; Cynthia A Carnes; George E Billman; Sandor Györke
Journal:  Circ Res       Date:  2012-01-05       Impact factor: 17.367

8.  Regulation of the gating of the sheep cardiac sarcoplasmic reticulum Ca(2+)-release channel by luminal Ca2+.

Authors:  R Sitsapesan; A J Williams
Journal:  J Membr Biol       Date:  1994-02       Impact factor: 1.843

9.  Messenger RNA expression and immunological quantification of phospholamban and SR-Ca(2+)-ATPase in failing and nonfailing human hearts.

Authors:  B Linck; P Bokník; T Eschenhagen; F U Müller; J Neumann; M Nose; L R Jones; W Schmitz; H Scholz
Journal:  Cardiovasc Res       Date:  1996-04       Impact factor: 10.787

10.  Scavenging free radicals by low-dose carvedilol prevents redox-dependent Ca2+ leak via stabilization of ryanodine receptor in heart failure.

Authors:  Mamoru Mochizuki; Masafumi Yano; Tetsuro Oda; Hiroki Tateishi; Shigeki Kobayashi; Takeshi Yamamoto; Yasuhiro Ikeda; Tomoko Ohkusa; Noriaki Ikemoto; Masunori Matsuzaki
Journal:  J Am Coll Cardiol       Date:  2007-04-05       Impact factor: 24.094
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  42 in total

1.  The role of spatial organization of Ca2+ release sites in the generation of arrhythmogenic diastolic Ca2+ release in myocytes from failing hearts.

Authors:  Andriy E Belevych; Hsiang-Ting Ho; Ingrid M Bonilla; Radmila Terentyeva; Karsten E Schober; Dmitry Terentyev; Cynthia A Carnes; Sándor Györke
Journal:  Basic Res Cardiol       Date:  2017-06-13       Impact factor: 17.165

Review 2.  A multidimensional sight on cardiac failure: uncovered from structural to molecular level.

Authors:  Vijay Urmaliya; Gustavo Franchelli
Journal:  Heart Fail Rev       Date:  2017-05       Impact factor: 4.214

Review 3.  New Insights in Cardiac Calcium Handling and Excitation-Contraction Coupling.

Authors:  Jessica Gambardella; Bruno Trimarco; Guido Iaccarino; Gaetano Santulli
Journal:  Adv Exp Med Biol       Date:  2018       Impact factor: 2.622

4.  Redox-sensitive residue in the actin-binding interface of myosin.

Authors:  Rebecca J Moen; Sinziana Cornea; Daniel E Oseid; Benjamin P Binder; Jennifer C Klein; David D Thomas
Journal:  Biochem Biophys Res Commun       Date:  2014-09-26       Impact factor: 3.575

5.  Nexilin Is Necessary for Maintaining the Transverse-Axial Tubular System in Adult Cardiomyocytes.

Authors:  Simone Spinozzi; Canzhao Liu; Ze'e Chen; Wei Feng; Lunfeng Zhang; Kunfu Ouyang; Sylvia M Evans; Ju Chen
Journal:  Circ Heart Fail       Date:  2020-07-08       Impact factor: 8.790

6.  Post-extrasystolic Potentiation: Link between Ca(2+) Homeostasis and Heart Failure?

Authors:  David J Sprenkeler; Marc A Vos
Journal:  Arrhythm Electrophysiol Rev       Date:  2016-05

7.  SK channel enhancers attenuate Ca2+-dependent arrhythmia in hypertrophic hearts by regulating mito-ROS-dependent oxidation and activity of RyR.

Authors:  Tae Yun Kim; Radmila Terentyeva; Karim H F Roder; Weiyan Li; Man Liu; Ian Greener; Shanna Hamilton; Iuliia Polina; Kevin R Murphy; Richard T Clements; Samuel C Dudley; Gideon Koren; Bum-Rak Choi; Dmitry Terentyev
Journal:  Cardiovasc Res       Date:  2017-03-01       Impact factor: 10.787

Review 8.  Sarcoplasmic reticulum calcium mishandling: central tenet in heart failure?

Authors:  Amanda L Denniss; Alexander M Dashwood; Peter Molenaar; Nicole A Beard
Journal:  Biophys Rev       Date:  2020-07-22

9.  Sodium nitrate supplementation alters mitochondrial H2O2 emission but does not improve mitochondrial oxidative metabolism in the heart of healthy rats.

Authors:  Cynthia M F Monaco; Paula M Miotto; Jason S Huber; Luc J C van Loon; Jeremy A Simpson; Graham P Holloway
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2018-03-07       Impact factor: 3.619

10.  HAX-1 regulates SERCA2a oxidation and degradation.

Authors:  Philip A Bidwell; Guan-Sheng Liu; Narayani Nagarajan; Chi Keung Lam; Kobra Haghighi; George Gardner; Wen-Feng Cai; Wen Zhao; Luke Mugge; Elizabeth Vafiadaki; Despina Sanoudou; Jack Rubinstein; Djamel Lebeche; Roger Hajjar; Junichi Sadoshima; Evangelia G Kranias
Journal:  J Mol Cell Cardiol       Date:  2017-11-21       Impact factor: 5.000
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