Literature DB >> 24512275

Alterations in platelet function during aging: clinical correlations with thromboinflammatory disease in older adults.

Donya Mohebali1, David Kaplan, McKenzie Carlisle, Mark A Supiano, Matthew T Rondina.   

Abstract

Platelets have a dynamic functional repertoire that mediates hemostatic and inflammatory responses. Many of these functions are altered in older adults, promoting a prothrombotic, proinflammatory milieu and contributing to risk of adverse clinical events. Drawing primarily from human studies, this review summarizes important aspects of aging-related changes in platelets. The relationship between altered platelet functions and thrombotic and inflammatory disorders in older adults is highlighted. Established and developing antiplatelet therapies for the treatment of thrombotic and inflammatory disorders are also discussed in light of these data.
© 2014, Copyright the Authors Journal compilation © 2014, The American Geriatrics Society.

Entities:  

Keywords:  aging; inflammation; monocyte; platelet; thrombosis

Mesh：

Year:  2014        PMID： 24512275      PMCID： PMC3959242          DOI： 10.1111/jgs.12700

Source DB:  PubMed          Journal:  J Am Geriatr Soc        ISSN： 0002-8614            Impact factor:   5.562


  54 in total

Review 1.  Nitric oxide insufficiency, platelet activation, and arterial thrombosis.

Authors:  J Loscalzo
Journal:  Circ Res       Date:  2001-04-27       Impact factor: 17.367

2.  Alterations of nitric oxide synthase expression with aging and hypertension in rats.

Authors:  T C Chou; M H Yen; C Y Li; Y A Ding
Journal:  Hypertension       Date:  1998-02       Impact factor: 10.190

3.  Acetylsalicylic acid, bleeding time and age.

Authors:  K A Jørgensen; J Dyerberg; A S Olesen; E Stoffersen
Journal:  Thromb Res       Date:  1980-09-15       Impact factor: 3.944

4.  Platelet activity and phosphoinositide turnover increase with advancing age.

Authors:  E J Bastyr; M M Kadrofske; A I Vinik
Journal:  Am J Med       Date:  1990-06       Impact factor: 4.965

5.  A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). CAPRIE Steering Committee.

Authors: 
Journal:  Lancet       Date:  1996-11-16       Impact factor: 79.321

Review 6.  Platelet-leukocyte interactions link inflammatory and thromboembolic events in ischemic stroke.

Authors:  Zechariah G Franks; Robert A Campbell; Andrew S Weyrich; Matthew T Rondina
Journal:  Ann N Y Acad Sci       Date:  2010-10       Impact factor: 5.691

7.  Inhibition of ADP-induced P-selectin expression and platelet-leukocyte conjugate formation by clopidogrel and the P2Y12 receptor antagonist AR-C69931MX but not aspirin.

Authors:  Robert F Storey; Heather M Judge; Robert G Wilcox; Stan Heptinstall
Journal:  Thromb Haemost       Date:  2002-09       Impact factor: 5.249

Review 8.  The epidemiology of venous thromboembolism.

Authors:  Richard H White
Journal:  Circulation       Date:  2003-06-17       Impact factor: 29.690

9.  Antiplatelet therapy is associated with decreased transfusion-associated risk of lung dysfunction, multiple organ failure, and mortality in trauma patients.

Authors:  Jeffrey N Harr; Ernest E Moore; Jeffrey Johnson; Theresa L Chin; Max V Wohlauer; Ronald Maier; Joseph Cuschieri; Jason Sperry; Anirban Banerjee; Christopher C Silliman; Angela Sauaia
Journal:  Crit Care Med       Date:  2013-02       Impact factor: 7.598

10.  Monocyte-platelet interaction induces a pro-inflammatory phenotype in circulating monocytes.

Authors:  Gabriella Passacquale; Padman Vamadevan; Luis Pereira; Colleen Hamid; Valerie Corrigall; Albert Ferro
Journal:  PLoS One       Date:  2011-10-12       Impact factor: 3.240
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  25 in total

1.  Efficacy of platelet-rich plasma as conservative treatment in orthopaedics.

Authors:  Nathan Clendenen; Adit Ginde
Journal:  Blood Transfus       Date:  2018-11       Impact factor: 3.443

2.  Increase of von Willebrand factor with aging in type 1 von Willebrand disease: fact or fiction?

Authors:  Mariachiara Borghi; Giuseppe Guglielmini; Anna Maria Mezzasoma; Emanuela Falcinelli; Loredana Bury; Marco Malvestiti; Paolo Gresele
Journal:  Haematologica       Date:  2017-07-27       Impact factor: 9.941

3.  Granzyme A in Human Platelets Regulates the Synthesis of Proinflammatory Cytokines by Monocytes in Aging.

Authors:  Robert A Campbell; Zechariah Franks; Anish Bhatnagar; Jesse W Rowley; Bhanu K Manne; Mark A Supiano; Hansjorg Schwertz; Andrew S Weyrich; Matthew T Rondina
Journal:  J Immunol       Date:  2017-11-22       Impact factor: 5.422

4.  2-Arachidonoylglycerol enhances platelet formation from human megakaryoblasts.

Authors:  Valeria Gasperi; Luciana Avigliano; Daniela Evangelista; Sergio Oddi; Valerio Chiurchiù; Mirko Lanuti; Mauro Maccarrone; Maria Valeria Catani
Journal:  Cell Cycle       Date:  2014       Impact factor: 4.534

Review 5.  Applied genomics in MPN presentation.

Authors:  Alison R Moliterno; Hannah Kaizer
Journal:  Hematology Am Soc Hematol Educ Program       Date:  2020-12-04

6.  Platelet-monocyte aggregate formation and mortality risk in older patients with severe sepsis and septic shock.

Authors:  Matthew T Rondina; McKenzie Carlisle; Tamra Fraughton; Samuel M Brown; Russell R Miller; Estelle S Harris; Andrew S Weyrich; Guy A Zimmerman; Mark A Supiano; Colin K Grissom
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2014-06-10       Impact factor: 6.053

Review 7.  Ageing, sex, and cardioprotection.

Authors:  Marisol Ruiz-Meana; Kerstin Boengler; David Garcia-Dorado; Derek J Hausenloy; Tuuli Kaambre; Georgios Kararigas; Cinzia Perrino; Rainer Schulz; Kirsti Ytrehus
Journal:  Br J Pharmacol       Date:  2020-02-03       Impact factor: 8.739

Review 8.  Modulators of platelet function in aging.

Authors:  Krishna S Iyer; Sanjana Dayal
Journal:  Platelets       Date:  2019-09-16       Impact factor: 3.862

9.  Age modification of ozone associations with cardiovascular disease risk in adults: a potential role for soluble P-selectin and blood pressure.

Authors:  Drew B Day; Merlise A Clyde; Jianbang Xiang; Feng Li; Xiaoxing Cui; Jinhan Mo; Jicheng Gong; Charles J Weschler; Yinping Zhang; Junfeng Jim Zhang
Journal:  J Thorac Dis       Date:  2018-07       Impact factor: 2.895

10.  Independent factors related to preoperative acute lung injury in 130 adults undergoing Stanford type-A acute aortic dissection surgery: a single-center cross-sectional clinical study.

Authors:  Xudong Pan; Jiakai Lu; Weiping Cheng; Yanwei Yang; Junming Zhu; Mu Jin
Journal:  J Thorac Dis       Date:  2018-07       Impact factor: 2.895
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