Cheryl D Bushnell1, Mathew J Reeves, Xin Zhao, Wenqin Pan, Janet Prvu-Bettger, Louise Zimmer, Daiwai Olson, Eric Peterson. 1. From Wake Forest School of Medicine (C.D.B.), Department of Neurology and Women's Health Center of Excellence for Leadership, Research, and Education, Winston-Salem, NC; Department of Epidemiology (M.J.R.), Michigan State University, East Lansing; Duke Clinical Research Institute (X.Z., W.P., J.P.-B., L.Z., E.P.), Durham; Duke University School of Nursing (J.P.-B.), Durham, NC; and University of Texas Southwestern (D.O.), Houston.
Abstract
OBJECTIVE: We aimed to compare quality of life (QOL) in women and men after ischemic stroke or TIA, and to determine the incremental impact of demographic, socioeconomic, clinical, and stroke-specific effects on longitudinal QOL. METHODS: We assessed QOL in patients with ischemic stroke or TIA at 3 and 12 months postdischarge in the Adherence eValuation After Ischemic stroke-Longitudinal Registry using the European Quality of Life-5 Dimensions (EQ-5D) instrument. We generated multivariable linear regression models to evaluate the association between sex and EQ-5D while sequentially adjusting for sociodemographic, clinical, and stroke-related variables. We also used a proportional odds model to assess sex differences in the change in EQ-5D scores from 3 to 12 months. RESULTS: A total of 1,370 patients were included, 53.7% male, median age 65 years (interquartile range 56-77 years). Women had significantly lower QOL at 3 months (unadjusted EQ-5D 0.81 in women vs 0.84 in men; p < 0.001) and 12 months (0.83 vs men 0.84; p < 0.001) poststroke. After multivariable adjustment for sociodemographic, clinical, and stroke-related factors, women continued to have lower QOL at 3 months (mean difference -0.036; p = 0.003) and at 12 months (mean difference -0.022; p = 0.046). Women fared worse in the dimensions of mobility, pain/discomfort, and anxiety/depression at 3 and 12 months. There were no sex differences in change in EQ-5D score from 3 to 12 months. CONCLUSION: Women have worse QOL than men up to 12 months after stroke, even after adjusting for important sociodemographic variables, stroke severity, and disability.
OBJECTIVE: We aimed to compare quality of life (QOL) in women and men after ischemic stroke or TIA, and to determine the incremental impact of demographic, socioeconomic, clinical, and stroke-specific effects on longitudinal QOL. METHODS: We assessed QOL in patients with ischemic stroke or TIA at 3 and 12 months postdischarge in the Adherence eValuation After Ischemic stroke-Longitudinal Registry using the European Quality of Life-5 Dimensions (EQ-5D) instrument. We generated multivariable linear regression models to evaluate the association between sex and EQ-5D while sequentially adjusting for sociodemographic, clinical, and stroke-related variables. We also used a proportional odds model to assess sex differences in the change in EQ-5D scores from 3 to 12 months. RESULTS: A total of 1,370 patients were included, 53.7% male, median age 65 years (interquartile range 56-77 years). Women had significantly lower QOL at 3 months (unadjusted EQ-5D 0.81 in women vs 0.84 in men; p < 0.001) and 12 months (0.83 vs men 0.84; p < 0.001) poststroke. After multivariable adjustment for sociodemographic, clinical, and stroke-related factors, women continued to have lower QOL at 3 months (mean difference -0.036; p = 0.003) and at 12 months (mean difference -0.022; p = 0.046). Women fared worse in the dimensions of mobility, pain/discomfort, and anxiety/depression at 3 and 12 months. There were no sex differences in change in EQ-5D score from 3 to 12 months. CONCLUSION:Women have worse QOL than men up to 12 months after stroke, even after adjusting for important sociodemographic variables, stroke severity, and disability.
Authors: Rodica E Petrea; Alexa S Beiser; Sudha Seshadri; Margaret Kelly-Hayes; Carlos S Kase; Philip A Wolf Journal: Stroke Date: 2009-02-10 Impact factor: 7.914
Authors: Michael J Leach; Seana L Gall; Helen M Dewey; Richard A L Macdonell; Amanda G Thrift Journal: J Neurol Neurosurg Psychiatry Date: 2011-05-07 Impact factor: 10.154
Authors: Cheryl Bushnell; Louise Zimmer; Lee Schwamm; Larry B Goldstein; Nancy Clapp-Channing; Tina Harding; Laura Drew; Xin Zhao; Eric Peterson Journal: Am Heart J Date: 2009-03 Impact factor: 4.749
Authors: Kurt Kroenke; Tara W Strine; Robert L Spitzer; Janet B W Williams; Joyce T Berry; Ali H Mokdad Journal: J Affect Disord Date: 2008-08-27 Impact factor: 4.839
Authors: Amy Y X Yu; Edwin Rogers; Meng Wang; Tolulope T Sajobi; Shelagh B Coutts; Bijoy K Menon; Michael D Hill; Eric E Smith Journal: Neurology Date: 2017-10-11 Impact factor: 9.910
Authors: Claudia West; Steven M Paul; Laura Dunn; Anand Dhruva; John Merriman; Christine Miaskowski Journal: Oncol Nurs Forum Date: 2015-09 Impact factor: 2.172