Zhengcun Pei1, Joachim Heinrich2, Elaine Fuertes3, Claudia Flexeder2, Barbara Hoffmann4, Irina Lehmann5, Beate Schaaf6, Andrea von Berg7, Sibylle Koletzko8. 1. Institute of Epidemiology I, German Research Center for Environmental Health, Neuherberg, Germany; Faculty of Medicine, Ludwig Maximilian University of Munich, Munich, Germany. 2. Institute of Epidemiology I, German Research Center for Environmental Health, Neuherberg, Germany. 3. Institute of Epidemiology I, German Research Center for Environmental Health, Neuherberg, Germany; School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada. 4. Leibniz Research Institute for Environmental Medicine, University of Düsseldorf, Düsseldorf, Germany; Medical Faculty, University of Düsseldorf, Düsseldorf, Germany. 5. Department of Environmental Immunology, Helmholz Center for Environmental Research, Leipzig, Germany; Department of Pediatrics, Technical University Munich, Munich, Germany. 6. Medical Practice for Pediatrics, Bad Honnef, Germany. 7. Department of Pediatrics, Marien-Hospital Wesel, Wesel, Germany. 8. Division of Pediatric, Gastroenterology, and Hepatology, Dr von Hauner Children's Hospital, Ludwig Maximilians University, Munich, Germany. Electronic address: sibylle.koletzko@med.uni-muenchen.de.
Abstract
OBJECTIVE: To investigate whether birth by cesarean delivery rather than vaginal delivery is a risk factor for later childhood obesity. STUDY DESIGN: Healthy, full-term infants were recruited. Overweight and obesity were defined using measured weight and height according to World Health Organization reference data. Associations between cesarean delivery and being overweight or obese were investigated at age 2, 6, and 10 years (n = 1734, 1244, and 1170, respectively) by multivariate logistic regression models adjusted for socioeconomic status, child characteristics, and maternal prepregnancy characteristics. RESULTS: Mothers who gave birth by cesarean delivery (∼17%) had a higher mean prepregnancy body mass index (23.7 kg/m(2) vs 22.5 kg/m(2)), greater mean gestational weight gain (15.3 kg vs 14.5 kg), and shorter mean duration of exclusive breastfeeding (3.4 months vs 3.8 months) compared with those who delivered vaginally. The proportion of obese children was greater in the cesarean delivery group compared with the vaginal delivery group at age 2 years (13.6% vs 8.3%), but not at older ages. Regression analyses revealed a greater likelihood of obesity at age 2 years in the cesarean delivery group compared with the vaginal delivery group at age 2 years (aOR, 1.68; 95% CI, 1.10-2.58), but not at age 6 years (aOR, 1.49; 95% CI, 0.55-4.05) or age 10 years (aOR, 1.16; 95% CI, 0.59-2.29). CONCLUSION: Cesarean delivery may increase the risk of obesity in early childhood. Our results do not support the hypothesis that an increasing rate of cesarean delivery contributes to obesity in childhood.
OBJECTIVE: To investigate whether birth by cesarean delivery rather than vaginal delivery is a risk factor for later childhood obesity. STUDY DESIGN: Healthy, full-term infants were recruited. Overweight and obesity were defined using measured weight and height according to World Health Organization reference data. Associations between cesarean delivery and being overweight or obese were investigated at age 2, 6, and 10 years (n = 1734, 1244, and 1170, respectively) by multivariate logistic regression models adjusted for socioeconomic status, child characteristics, and maternal prepregnancy characteristics. RESULTS: Mothers who gave birth by cesarean delivery (∼17%) had a higher mean prepregnancy body mass index (23.7 kg/m(2) vs 22.5 kg/m(2)), greater mean gestational weight gain (15.3 kg vs 14.5 kg), and shorter mean duration of exclusive breastfeeding (3.4 months vs 3.8 months) compared with those who delivered vaginally. The proportion of obesechildren was greater in the cesarean delivery group compared with the vaginal delivery group at age 2 years (13.6% vs 8.3%), but not at older ages. Regression analyses revealed a greater likelihood of obesity at age 2 years in the cesarean delivery group compared with the vaginal delivery group at age 2 years (aOR, 1.68; 95% CI, 1.10-2.58), but not at age 6 years (aOR, 1.49; 95% CI, 0.55-4.05) or age 10 years (aOR, 1.16; 95% CI, 0.59-2.29). CONCLUSION: Cesarean delivery may increase the risk of obesity in early childhood. Our results do not support the hypothesis that an increasing rate of cesarean delivery contributes to obesity in childhood.
Authors: S Hansen; T I Halldorsson; S F Olsen; D Rytter; B H Bech; C Granström; T B Henriksen; J E Chavarro Journal: Int J Obes (Lond) Date: 2017-07-31 Impact factor: 5.095
Authors: Andrea E Cassidy-Bushrow; Ganesa Wegienka; Suzanne Havstad; Albert M Levin; Susan V Lynch; Dennis R Ownby; Andrew G Rundle; Kimberley J Woodcroft; Edward M Zoratti; Christine Cole Johnson Journal: Matern Child Health J Date: 2015-06
Authors: Christian Milani; Sabrina Duranti; Francesca Bottacini; Eoghan Casey; Francesca Turroni; Jennifer Mahony; Clara Belzer; Susana Delgado Palacio; Silvia Arboleya Montes; Leonardo Mancabelli; Gabriele Andrea Lugli; Juan Miguel Rodriguez; Lars Bode; Willem de Vos; Miguel Gueimonde; Abelardo Margolles; Douwe van Sinderen; Marco Ventura Journal: Microbiol Mol Biol Rev Date: 2017-11-08 Impact factor: 11.056