CONTEXT: Elevated plasmatic microRNAs (miRs) are observed in heart failure (HF). However, the cardiac origin of these miRs remains unclear. OBJECTIVE: We calculated transcoronary gradients of miR-29b, miR-133a and miR-423-5p in 17 outpatients with stable systolic HF and in controls without structural cardiac disease. MATERIALS AND METHODS: MicroRNAs were measured by quantitative real-time polymerase chain reaction. RESULTS: Positive transcoronary miR gradients were observed in patients with HF but not in controls (p = 0.03). B-type natriuretic peptide (BNP) moderately correlated with the transcoronary gradients of miR-133a and miR-423-5p. DISCUSSION AND CONCLUSIONS: The difference in transcoronary gradients between HF outpatients and controls suggests that miR-423-5p has a cardiac origin. The positive correlation between miR-423-5p and BNP transcoronary gradients supports this hypothesis.
CONTEXT: Elevated plasmatic microRNAs (miRs) are observed in heart failure (HF). However, the cardiac origin of these miRs remains unclear. OBJECTIVE: We calculated transcoronary gradients of miR-29b, miR-133a and miR-423-5p in 17 outpatients with stable systolic HF and in controls without structural cardiac disease. MATERIALS AND METHODS: MicroRNAs were measured by quantitative real-time polymerase chain reaction. RESULTS: Positive transcoronary miR gradients were observed in patients with HF but not in controls (p = 0.03). B-type natriuretic peptide (BNP) moderately correlated with the transcoronary gradients of miR-133a and miR-423-5p. DISCUSSION AND CONCLUSIONS: The difference in transcoronary gradients between HF outpatients and controls suggests that miR-423-5p has a cardiac origin. The positive correlation between miR-423-5p and BNP transcoronary gradients supports this hypothesis.
Authors: Ravi Shah; Olivia Ziegler; Ashish Yeri; Xiaojun Liu; Venkatesh Murthy; Dustin Rabideau; Chun Yang Xiao; Kristina Hanspers; Arianna Belcher; Michael Tackett; Anthony Rosenzweig; Alexander R Pico; James L Januzzi; Saumya Das Journal: Circ Heart Fail Date: 2018-02 Impact factor: 8.790
Authors: Alicia D'Souza; Charles M Pearman; Yanwen Wang; Shu Nakao; Sunil Jit R J Logantha; Charlotte Cox; Hayley Bennett; Yu Zhang; Anne Berit Johnsen; Nora Linscheid; Pi Camilla Poulsen; Jonathan Elliott; Jessica Coulson; Jamie McPhee; Abigail Robertson; Paula A da Costa Martins; Ashraf Kitmitto; Ulrik Wisløff; Elizabeth J Cartwright; Oliver Monfredi; Alicia Lundby; Halina Dobrzynski; Delvac Oceandy; Gwilym M Morris; Mark R Boyett Journal: Circ Res Date: 2017-08-17 Impact factor: 17.367
Authors: Nazanin Hakimzadeh; A Yaël Nossent; Anja M van der Laan; Stephan H Schirmer; Maurice W J de Ronde; Sara-Joan Pinto-Sietsma; Niels van Royen; Paul H A Quax; Imo E Hoefer; Jan J Piek Journal: PLoS One Date: 2015-09-02 Impact factor: 3.240
Authors: Suvi M Kuosmanen; Juha Hartikainen; Mikko Hippeläinen; Hannu Kokki; Anna-Liisa Levonen; Pasi Tavi Journal: PLoS One Date: 2015-03-12 Impact factor: 3.240