Nicola Rosa1, Michele Lanza2,3, Maddalena De Bernardo1, Giuseppe Signoriello4, Paolo Chiodini4. 1. a Department of Medicine and Surgery , University of Salerno , Salerno , Italy . 2. b Multidisciplinary Department of Medical , Surgical and Dental Specialities, Seconda Università di Napoli , Naples , Italy . 3. c Centro Grandi Apparecchiature, Seconda Università di Napoli , Naples , Italy , and. 4. d Biostatistics Unit, Department of Medicine and Public Health , Seconda Università di Napoli , Naples , Italy.
Abstract
PURPOSE: To evaluate the relationship between corneal hysteresis (CH) and corneal resistance factor (CRF) with age, central corneal thickness (CCT), corneal curvature (KM), corneal volume (CV), and refractive error in naïve eyes. METHODS: 105 healthy subjects (58 male and 47 female) were included in this study. The ages ranged from 19 to 82 years (mean 43.1 ± 15.4 years) and refraction between -11 D and +6 D (mean -0.79 ± 2.95 D). CH and CRF obtained with the Ocular Response Analyzer (ORA) were correlated with age, refractive error, Goldmann Applanation Tonometry (GAT), and with CCT, KM, CV obtained with the Pentacam, and with Corneal-Compensated Intraocular Pressure (IOPcc) and Goldmann-correlated intraocular pressure measurement (IOPg) obtained with ORA. A multivariable mixed effect model was used to evaluate associations among these parameters. RESULTS: CH ranged from 6.9 to 14.6 mmHg (mean 10.26 ± 1.49 mmHg); CRF ranged from 5.8 to 17 mmHg (mean 10.38 ± 1.64 mmHg). Multivariate analysis showed a statistically significant correlation between CH with CCT (p < 0.001), and KM (p < 0.001), and between CRF with CCT (p < 0.001) and GAT (p < 0.001). CONCLUSIONS: Our findings support the hypothesis that CH and CRF are related to the corneal shape and thickness, and show a decrease of CH with age.
PURPOSE: To evaluate the relationship between corneal hysteresis (CH) and corneal resistance factor (CRF) with age, central corneal thickness (CCT), corneal curvature (KM), corneal volume (CV), and refractive error in naïve eyes. METHODS: 105 healthy subjects (58 male and 47 female) were included in this study. The ages ranged from 19 to 82 years (mean 43.1 ± 15.4 years) and refraction between -11 D and +6 D (mean -0.79 ± 2.95 D). CH and CRF obtained with the Ocular Response Analyzer (ORA) were correlated with age, refractive error, Goldmann Applanation Tonometry (GAT), and with CCT, KM, CV obtained with the Pentacam, and with Corneal-Compensated Intraocular Pressure (IOPcc) and Goldmann-correlated intraocular pressure measurement (IOPg) obtained with ORA. A multivariable mixed effect model was used to evaluate associations among these parameters. RESULTS: CH ranged from 6.9 to 14.6 mmHg (mean 10.26 ± 1.49 mmHg); CRF ranged from 5.8 to 17 mmHg (mean 10.38 ± 1.64 mmHg). Multivariate analysis showed a statistically significant correlation between CH with CCT (p < 0.001), and KM (p < 0.001), and between CRF with CCT (p < 0.001) and GAT (p < 0.001). CONCLUSIONS: Our findings support the hypothesis that CH and CRF are related to the corneal shape and thickness, and show a decrease of CH with age.
Authors: Eileen S Hwang; Brian C Stagg; Russell Swan; Carlton R Fenzl; Molly McFadden; Valliammai Muthappan; Luis Santiago-Caban; Mark D Mifflin; Majid Moshirfar Journal: Clin Ophthalmol Date: 2017-10-03