| Literature DB >> 24504940 |
Roman V Shutov1, Antonio Guerreiro, Ewa Moczko, Isabel Perez de Vargas-Sansalvador, Iva Chianella, Michael J Whitcombe, Sergey A Piletsky.
Abstract
A new ELISA- (enzyme-linked immunosorbent assay)-like assay is demonstrated in which no elements of biological origin are used for molecular recognition or signaling. Composite imprinted nanoparticles that contain a catalytic core and which are synthesized by using a solid-phase approach can simultaneously act as recognition/signaling elements, and be used with minimal modifications to standard assay protocols. This assay provides a new route towards replacement of unstable biomolecules in immunoassays.Entities:
Keywords: core-shell materials; molecular imprinting; peroxidases; solid-phase synthesis
Mesh:
Substances:
Year: 2014 PMID: 24504940 PMCID: PMC4719181 DOI: 10.1002/smll.201301996
Source DB: PubMed Journal: Small ISSN: 1613-6810 Impact factor: 13.281