| Literature DB >> 24503621 |
Yujing Huang1, Junnan Li2, Jose M Garcia3, Hui Lin4, Yanzhou Wang2, Ping Yan2, Lingqiao Wang1, Yao Tan1, Jiaohua Luo1, Zhiqun Qiu1, Ji-an Chen5, Weiqun Shu1.
Abstract
Data concerning the effects of phthalate exposure on preterm delivery and fetal growth are limited in humans. In this paper, we assessed the relationship between 15 phthalate levels in cord blood and preterm delivery and fetal growth parameters in 207 Chinese women going into labor. Exposure to phthalates except DCHP was associated with gestational age reduction and preterm delivery (p<0.05). There were associations between phthalates and fetal growth parameters, many of which disappeared when analyses were adjusted for gestational age, especially in male infants (Only DEEP was associated with birth weight; DEP, DNHP, BBP, DNP with abdominal circumference; DEP, DBP, DCHP, DEHP with femur length in female infants. And DPP, DBEP was associated with birth length in male infants. p<0.05). This study indicates that prenatal exposure to phthalates is associated with younger gestational age and preterm delivery. Also, phthalate exposure may adversely affect fetal growth parameters via gestational age reduction and preterm delivery with a significant gender effect.Entities:
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Year: 2014 PMID： 24503621 PMCID： PMC3913614 DOI： 10.1371/journal.pone.0087430
Source DB: PubMed Journal: PLoS One ISSN： 1932-6203 Impact factor: 3.240