Junbin Han1, Robert S Paton2, Bo Xu1, Gerald B Hammond1. 1. Department of Chemistry, University of Louisville, Louisville, KY 40292, USA. 2. Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK.
Abstract
A copper-catalyzed tandem cyclization triggered addition strategy that relies on electrophilic enamine activation has been used to synthesize various cyclic α-aminophosphonates derivatives in good to excellent yields. Both five and six membered rings can be generated under mild conditions with high regioselectivity. A mechanism based on copper catalyzed enamine activation is proposed.
A copper-catalyzed tandem cyclization triggered addition strategy that relies on electrophilic n class="Chemical">enamine activation has been used to synthesize various cyclic α-aminophosphonates derivatives in good to excellent yields. Both five and six membered rings can be generated under mild conditions with high regioselectivity. A mechanism based on copper catalyzed enamine activation is proposed.
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