Literature DB >> 24499327

Cladosins A-E, hybrid polyketides from a deep-sea-derived fungus, Cladosporium sphaerospermum.

Guangwei Wu1, Xinhua Sun, Guihong Yu, Wei Wang, Tianjiao Zhu, Qianqun Gu, Dehai Li.   

Abstract

Five new fungal hybrid polyketides, cladosins A-D (1-4), that contain a novel linear 6(3)-enamino-8,10-dihydroxy-tetraketide (1 and 2) or 6-enamino-7(8)-en-10-ol (3 and 4) moiety, as well as the biogenetically related cladosin E (5), were isolated from the deep-sea-derived fungus Cladosporium sphaerospermum 2005-01-E3. Their structures (1-5) were elucidated through a combination of spectroscopic data, chemical conversion, and both Mosher's and Marfey's methods for stereochemical assignment. A plausible biogenetic pathway to 1-5 is proposed. Cladosin C (3) possesses mild anti-influenza A H1N1 virus activity.

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Year:  2014        PMID： 24499327     DOI： 10.1021/np400833x

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  21 in total

Review 1.  Untapped Potential of Marine-Associated Cladosporium Species: An Overview on Secondary Metabolites, Biotechnological Relevance, and Biological Activities.

Authors:  Gamal A Mohamed; Sabrin R M Ibrahim
Journal:  Mar Drugs       Date:  2021-11-18       Impact factor: 5.118

Review 2.  Potential Antiviral Agents from Marine Fungi: An Overview.

Authors:  Soheil Zorofchian Moghadamtousi; Sonia Nikzad; Habsah Abdul Kadir; Sazaly Abubakar; Keivan Zandi
Journal:  Mar Drugs       Date:  2015-07-22       Impact factor: 5.118

3.  Insight into different environmental niches adaptation and allergenicity from the Cladosporium sphaerospermum genome, a common human allergy-eliciting Dothideomycetes.

Authors:  Su Mei Yew; Chai Ling Chan; Yun Fong Ngeow; Yue Fen Toh; Shiang Ling Na; Kok Wei Lee; Chee-Choong Hoh; Wai-Yan Yee; Kee Peng Ng; Chee Sian Kuan
Journal:  Sci Rep       Date:  2016-05-31       Impact factor: 4.379

4.  Exploring the Antibacterial and Antifungal Potential of Jellyfish-Associated Marine Fungi by Cultivation-Dependent Approaches.

Authors:  Yang Yue; Huahua Yu; Rongfeng Li; Ronge Xing; Song Liu; Pengcheng Li
Journal:  PLoS One       Date:  2015-12-04       Impact factor: 3.240

Review 5.  Potential of small-molecule fungal metabolites in antiviral chemotherapy.

Authors:  Biswajit G Roy
Journal:  Antivir Chem Chemother       Date:  2017-07-23

Review 6.  The Genus Cladosporium: A Rich Source of Diverse and Bioactive Natural Compounds.

Authors:  Maria Michela Salvatore; Anna Andolfi; Rosario Nicoletti
Journal:  Molecules       Date:  2021-06-28       Impact factor: 4.411

7.  Macrolactin A as a Novel Inhibitory Agent for SARS-CoV-2 Mpro: Bioinformatics Approach.

Authors:  Kaushik Kumar Bharadwaj; Tanmay Sarkar; Arabinda Ghosh; Debabrat Baishya; Bijuli Rabha; Manasa Kumar Panda; Bryan Raveen Nelson; Akbar B John; Hassan I Sheikh; Bisnu Prasad Dash; Hisham Atan Edinur; Siddhartha Pati
Journal:  Appl Biochem Biotechnol       Date:  2021-07-01       Impact factor: 2.926

8.  New polyphenols from a deep sea Spiromastix sp. Fungus, and their antibacterial activities.

Authors:  Siwen Niu; Dong Liu; Peter Proksch; Zongze Shao; Wenhan Lin
Journal:  Mar Drugs       Date:  2015-04-22       Impact factor: 5.118

Review 9.  A Brief Review of Bioactive Metabolites Derived from Deep-Sea Fungi.

Authors:  Yan-Ting Wang; Ya-Rong Xue; Chang-Hong Liu
Journal:  Mar Drugs       Date:  2015-07-23       Impact factor: 5.118

Review 10.  Antiviral potential of natural products from marine microbes.

Authors:  Mengqi Yi; Sixiao Lin; Bin Zhang; Haixiao Jin; Lijian Ding
Journal:  Eur J Med Chem       Date:  2020-08-31       Impact factor: 6.514
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