CONTEXT: Subarachnoid hemorrhage (SAH) has a high fatality rate and many suffer from delayed neurological deficits. Biomarkers may aid in the identification of high-risk patients, guide treatment/management and improve outcome. OBJECTIVE: The aim of this review was to summarize biomarkers of SAH associated with outcome. METHODS: An electronic database query was completed, including an additional review of reference lists to include all potential human studies. RESULTS: A total of 298 articles were identified; 112 were reviewed; 55 studies were included. CONCLUSION: This review details biomarkers of SAH that correlate with outcome. It provides the basis for research investigating their possible translation into the management of SAH patients.
CONTEXT: Subarachnoid hemorrhage (SAH) has a high fatality rate and many suffer from delayed neurological deficits. Biomarkers may aid in the identification of high-risk patients, guide treatment/management and improve outcome. OBJECTIVE: The aim of this review was to summarize biomarkers of SAH associated with outcome. METHODS: An electronic database query was completed, including an additional review of reference lists to include all potential human studies. RESULTS: A total of 298 articles were identified; 112 were reviewed; 55 studies were included. CONCLUSION: This review details biomarkers of SAH that correlate with outcome. It provides the basis for research investigating their possible translation into the management of SAHpatients.
Authors: Eduardo Martínez-Morillo; Anastasia Diamandis; Alexander D Romaschin; Eleftherios P Diamandis Journal: PLoS One Date: 2012-09-25 Impact factor: 3.240
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