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Literature DB >> 24496855

PI3K/Akt pathway involving into apoptosis and invasion in human colon cancer cells LoVo.

Qun Guang Jiang¹, Tai Yuan Li, Dong Ning Liu, Hai Tao Zhang.

Abstract

In this study we determined the effects of Curcumin on human colon cancer cells line LoVo. We found that Curcumin significantly inhibited the proliferation, migration and invasion, and clone formation of LoVo cells in a dose-dependent manner. Curcumin also dose-dependently reduced the phosphorylation of proteins Akt and increased expression levels of the genes caspase-3, cytochrome-c, Bax mRNA in LoVo cells. In addition, Curcumin dose-dependently decreased gene Bcl-2 mRNA expression. Similar results were observed in LoVo cells treated with LY294002. These in vitro studies suggest that Curcumin may play its anti-cancer actions partly via suppressing PI3K/Akt signal pathway in LoVo cells.

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Year: 2014 PMID： 24496855 DOI： 10.1007/s11033-014-3198-2

Source DB: PubMed Journal: Mol Biol Rep ISSN： 0301-4851 Impact factor: 2.316

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