OBJECTIVE: Cervical cancer screening by human papillomavirus (HPV) testing requires the use of additional triage and follow-up analyses. We evaluated women's compliance with and the performance of this strategy in a routine setting. SETTING: Five cervical service screening programmes in North-East Italy. METHODS: Eligible women aged 25-64 invited for a new screening episode underwent HPV testing for high risk types (hrHPV by Hybrid Capture 2) and cytology triage. Women with positive HPV and cytology results were referred for colposcopy; women with positive HPV but negative cytology results were referred to 1-year repeat hrHPV testing. RESULTS: Of 46,694 women screened by HPV testing up to December 2011, 3,211 (6.9%) tested hrHPV positive; 45% of these had a positive triage cytology. Those with negative cytology were invited for 1-yr repeat testing. Compliance with invitation was 61.6% at baseline and 85.3% at 1-yr repeat. Rate of persistent hrHPV positivity was 58% (830/1,435). Colposcopy performed in women with a positive hrHPV test at 1-yr repeat accounted for 36% of all colposcopies performed within the screening programmes. Cumulatively, a histological high-grade lesion was detected in 276 women (5.9‰ detection rate), 234 at baseline (85%), and 42 (15%) at 1-yr repeat. CONCLUSIONS: Compliance with hrHPV-based screening programmes was high both at baseline and at 1-yr repeat. Compared with the randomized trials, a higher proportion of triage cytology was read as positive, and only a small number of high-grade lesions were detected among the group of hrHPV positive cytology negative women who repeated testing 1-yr after baseline.
OBJECTIVE: Cervical cancer screening by human papillomavirus (HPV) testing requires the use of additional triage and follow-up analyses. We evaluated women's compliance with and the performance of this strategy in a routine setting. SETTING: Five cervical service screening programmes in North-East Italy. METHODS: Eligible women aged 25-64 invited for a new screening episode underwent HPV testing for high risk types (hrHPV by Hybrid Capture 2) and cytology triage. Women with positive HPV and cytology results were referred for colposcopy; women with positive HPV but negative cytology results were referred to 1-year repeat hrHPV testing. RESULTS: Of 46,694 women screened by HPV testing up to December 2011, 3,211 (6.9%) tested hrHPV positive; 45% of these had a positive triage cytology. Those with negative cytology were invited for 1-yr repeat testing. Compliance with invitation was 61.6% at baseline and 85.3% at 1-yr repeat. Rate of persistent hrHPV positivity was 58% (830/1,435). Colposcopy performed in women with a positive hrHPV test at 1-yr repeat accounted for 36% of all colposcopies performed within the screening programmes. Cumulatively, a histological high-grade lesion was detected in 276 women (5.9‰ detection rate), 234 at baseline (85%), and 42 (15%) at 1-yr repeat. CONCLUSIONS: Compliance with hrHPV-based screening programmes was high both at baseline and at 1-yr repeat. Compared with the randomized trials, a higher proportion of triage cytology was read as positive, and only a small number of high-grade lesions were detected among the group of hrHPV positive cytology negative women who repeated testing 1-yr after baseline.
Authors: Paolo Giorgi Rossi; Simonetta Bisanzi; Elena Allia; Alessandra Mongia; Francesca Carozzi; Anna Gillio-Tos; Laura De Marco; Guglielmo Ronco; Daniela Gustinucci; Annarosa Del Mistro; Helena Frayle; Anna Iossa; Giulia Fantacci; Giampaolo Pompeo; Elena Cesarini; Simonetta Bulletti; Basilio Passamonti; Martina Rizzi; Maria Gabriella Penon; Alessandra Barca; Maria Benevolo Journal: J Clin Microbiol Date: 2017-01-18 Impact factor: 5.948
Authors: P Giorgi Rossi; C Fortunato; P Barbarino; S Boveri; S Caroli; A Del Mistro; A Ferro; C Giammaria; M Manfredi; T Moretto; A Pasquini; M Sideri; M C Tufi; C Cogo; E Altobelli Journal: Br J Cancer Date: 2015-01-29 Impact factor: 7.640
Authors: Annarosa Del Mistro; Helena Frayle; Antonio Ferro; Gianpiero Fantin; Emma Altobelli; Paolo Giorgi Rossi Journal: Prev Med Rep Date: 2016-12-23
Authors: Matejka Rebolj; Janet Rimmer; Karin Denton; John Tidy; Christopher Mathews; Kay Ellis; John Smith; Chris Evans; Thomas Giles; Viki Frew; Xenia Tyler; Alexandra Sargent; Janet Parker; Miles Holbrook; Katherine Hunt; Penny Tidbury; Tanya Levine; David Smith; Julietta Patnick; Ruth Stubbs; Sue Moss; Henry Kitchener Journal: BMJ Date: 2019-02-06