BACKGROUND: Obesity is a growing worldwide epidemic. There is association between obesity and pancreatic cancer risk. However, the impact of obesity on the outcome of pancreatoduodenectomy (PD) is controversial. The aim of this study was to elucidate effect of obesity on surgical outcomes of PD. STUDY DESIGN: A case-control study. PATIENT AND METHODS: We retrospectively studied all patients who underwent PD in our center between January 2000 and June 2012. Patients were divided into two groups; Group A (patients with BMI <25) and Group B (patients with BMI > 25). Preoperative demographic data, intraoperative data, and postoperative details were collected. RESULTS: Only 112/471 patients (25.9%) had BMI > 25. The median intraoperative blood loss was more in overweight patients (P = 0.06). The median surgical time in group B was significantly longer than that in group A (P = 0.003). The overall incidence of complications was higher in the overweight group (P = 0.001). The severity of complications was also higher in the overweight group (P = 0.0001). Postoperative pancreatic fistula (POPF) (P = 0.0001) and hospital mortality (P = 0.001) were significantly higher in overweight patients. Oral intake was significantly delayed in overweight patients in comparison to normal weight group (P = 0.02). Postoperative stay was significantly longer in overweight patients (P = 0.0001). CONCLUSION: PD is associated with an increased risk of postoperative morbidity in overweight patient. Overweight patients must not be precluded from undergoing PD. However, operative techniques and pharmacological prophylaxis to decrease POPF should be considered in overweight patients.
BACKGROUND:Obesity is a growing worldwide epidemic. There is association between obesity and pancreatic cancer risk. However, the impact of obesity on the outcome of pancreatoduodenectomy (PD) is controversial. The aim of this study was to elucidate effect of obesity on surgical outcomes of PD. STUDY DESIGN: A case-control study. PATIENT AND METHODS: We retrospectively studied all patients who underwent PD in our center between January 2000 and June 2012. Patients were divided into two groups; Group A (patients with BMI <25) and Group B (patients with BMI > 25). Preoperative demographic data, intraoperative data, and postoperative details were collected. RESULTS: Only 112/471 patients (25.9%) had BMI > 25. The median intraoperative blood loss was more in overweight patients (P = 0.06). The median surgical time in group B was significantly longer than that in group A (P = 0.003). The overall incidence of complications was higher in the overweight group (P = 0.001). The severity of complications was also higher in the overweight group (P = 0.0001). Postoperative pancreatic fistula (POPF) (P = 0.0001) and hospital mortality (P = 0.001) were significantly higher in overweight patients. Oral intake was significantly delayed in overweight patients in comparison to normal weight group (P = 0.02). Postoperative stay was significantly longer in overweight patients (P = 0.0001). CONCLUSION:PD is associated with an increased risk of postoperative morbidity in overweight patient. Overweight patients must not be precluded from undergoing PD. However, operative techniques and pharmacological prophylaxis to decrease POPF should be considered in overweight patients.
Authors: Victor P Gazivoda; Alissa Greenbaum; Matthew A Beier; Catherine H Davis; Aaron W Kangas-Dick; Russell C Langan; Miral S Grandhi; David A August; H Richard Alexander; Henry A Pitt; Timothy J Kennedy Journal: J Gastrointest Surg Date: 2022-06-29 Impact factor: 3.267
Authors: Ayman El Nakeeb; Waleed Askar; Ehab Atef; Ehab El Hanafy; Ahmad M Sultan; Tarek Salah; Ahmed Shehta; Mohamed El Sorogy; Emad Hamdy; Mohamed El Hemly; Ahmed A El-Geidi; Tharwat Kandil; Mohamed El Shobari; Talaat Abd Allah; Amgad Fouad; Mostafa Abu Zeid; Ahmed Abu El Eneen; Nabil Gad El-Hak; Gamal El Ebidy; Omar Fathy; Ahmed Sultan; Mohamed Abdel Wahab Journal: World J Gastroenterol Date: 2017-10-14 Impact factor: 5.742
Authors: Elizabeth Alvarez; Majdi Qutob; Lawrence Mbuagbaw; John Lavis; Cynthia Lokker; Marjan Walli-Attaei; Zainab Samaan; Arielle Sutton; Japteg Singh; David Feeny; John Fortuna Journal: BMJ Open Date: 2019-10-16 Impact factor: 2.692