| Literature DB >> 24486742 |
Jingjing Liu1, Xu Wang2, Xiaoning Yang1, Yunpeng Liu2, Ying Shi2, Jianlin Ren3, Bayasi Guleng4.
Abstract
TFF1 is a small, secreted protein in the TFF family that has a pivotal role as a motogenic factor in epithelial restitution and cell motility, and as a tumor suppressor gene in the stomach. In this study, we identified TFF1 as a novel target gene of miRNA-423-5p. miRNA-423-5p negatively regulated the expression of TFF1 by binding to its 3'UTR and participated in proliferation/invasion-related processes via a TFF1-dependent manner in gastric cancer cells. Our findings suggested that miR-423-5p may be a novel target for the future development of specific therapeutic interventions for gastric cancer.Entities:
Keywords: Expression regulation; Gastric cancer; Proliferation and invasion; Trefoil factor 1 (TFF1); miR-423-5p
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Year: 2014 PMID： 24486742 DOI： 10.1016/j.canlet.2014.01.024
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679