Xuan Yang1, Lei Feng2, Changjiang Li3, Yu Li4. 1. Department of Cardiology, Qingdao Municipal Hospital, Qingdao 266000, China. Electronic address: yangxuan_qdh@163.com. 2. Diagnostic Imaging Division, Qingdao Municipal Hospital, Qingdao 266000, China. 3. Intensive Care Unit, Qingdao Central Hospital, Qingdao 266000, China. 4. Zibo Municipal Hospital Authorities Internal Medicine, Zibo 255000, China.
Abstract
AIM: To investigate the association between interleukin-6 (IL-6) -174G>C and -572C>G polymorphisms and risk for ischemic stroke (IS) in young patients. METHODS: We genotyped IL-6 -174G>C and -572C>G in a case-control study of 430 young IS patients and 461 control subjects. An unconditional multiple logistical regression model was used to calculate the effects of IL-6-174G>C and -572C>G polymorphisms on IS risk. RESULTS: Higher body mass index, diabetes, hypertension, obesity, and smoking were associated with risk of ischemic stroke. Multivariate regression analyses showed that subjects carrying the -174CC genotype (OR=1.69, 95% CI=1.16-2.57) and C allele (OR=1.37, 95% CI=1.09-1.67) had a small but significant increased risk of IS. Similarly, those carrying the -572GG genotype (OR=2.12, 95% CI=1.18-3.82) and G allele (OR=1.43, 95% CI=1.14-1.83) had a moderate increased risk of IS. We found the -174G>C and -572C>G polymorphisms interact with hypertension and obesity. CONCLUSION: Our results suggest that polymorphisms in IL-6-174G>C and -572C>G are associated with IS risk in young patients, and that these polymorphisms interact with hypertension, obesity and etiologic subtypes. These findings could be helpful in identifying individuals at increased risk for developing IS.
AIM: To investigate the association between interleukin-6 (IL-6) -174G>C and -572C>G polymorphisms and risk for ischemic stroke (IS) in young patients. METHODS: We genotyped IL-6 -174G>C and -572C>G in a case-control study of 430 young IS patients and 461 control subjects. An unconditional multiple logistical regression model was used to calculate the effects of IL-6-174G>C and -572C>G polymorphisms on IS risk. RESULTS: Higher body mass index, diabetes, hypertension, obesity, and smoking were associated with risk of ischemic stroke. Multivariate regression analyses showed that subjects carrying the -174CC genotype (OR=1.69, 95% CI=1.16-2.57) and C allele (OR=1.37, 95% CI=1.09-1.67) had a small but significant increased risk of IS. Similarly, those carrying the -572GG genotype (OR=2.12, 95% CI=1.18-3.82) and G allele (OR=1.43, 95% CI=1.14-1.83) had a moderate increased risk of IS. We found the -174G>C and -572C>G polymorphisms interact with hypertension and obesity. CONCLUSION: Our results suggest that polymorphisms in IL-6-174G>C and -572C>G are associated with IS risk in young patients, and that these polymorphisms interact with hypertension, obesity and etiologic subtypes. These findings could be helpful in identifying individuals at increased risk for developing IS.
Authors: Nancy Swords Jenny; Peter W Callas; Suzanne E Judd; Leslie A McClure; Brett Kissela; Neil A Zakai; Mary Cushman Journal: Neurology Date: 2019-04-19 Impact factor: 9.910