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Literature DB >> 24486448

The dynamic metabolism of hyaluronan regulates the cytosolic concentration of UDP-GlcNAc.

Vincent C Hascall¹, Aimin Wang², Markku Tammi³, Sanna Oikari³, Raija Tammi³, Alberto Passi⁴, Davide Vigetti⁴, Richard W Hanson⁵, Gerald W Hart⁶.

Abstract

Hyaluronan, a macromolecular glycosaminoglycan, is normally synthesized by hyaluronan synthases at the plasma membrane using cytosolic UDP-GlcUA and UDP-GlcNAc substrates and extruding the elongating chain into the extracellular space. The cellular metabolism (synthesis and catabolism) of hyaluronan is dynamic. UDP-GlcNAc is also the substrate for O-GlcNAc transferase, which is central to the control of many cytosolic pathways. This Perspective outlines recent data for regulation of hyaluronan synthesis and catabolism that support a model that hyaluronan metabolism can be a rheostat for controlling an acceptable normal range of cytosolic UDP-GlcNAc concentrations in order to maintain normal cell functions.

Entities: Chemical Disease Gene Species

Keywords: Hyaluronan; Hyaluronan synthases; O-GlcNAc transferase; UDP-GlcNAc

Mesh：

Substances：

Year: 2014 PMID： 24486448 PMCID： PMC4039572 DOI： 10.1016/j.matbio.2014.01.014

Source DB: PubMed Journal: Matrix Biol ISSN： 0945-053X Impact factor: 11.583

20 in total

1. Hyaluronan minireview series.

Authors: John McDonald; Vincent C Hascall
Journal: J Biol Chem Date: 2001-11-20 Impact factor: 5.157

Review 2. Protein O-GlcNAcylation in diabetes and diabetic complications.

Authors: Junfeng Ma; Gerald W Hart
Journal: Expert Rev Proteomics Date: 2013-08 Impact factor: 3.940

Review 3. Hyaluronan catabolism: a new metabolic pathway.

Authors: Robert Stern
Journal: Eur J Cell Biol Date: 2004-08 Impact factor: 4.492

Review 4. Hyaluronan synthases.

Authors: P H Weigel; V C Hascall; M Tammi
Journal: J Biol Chem Date: 1997-05-30 Impact factor: 5.157

5. Mannose inhibits hyaluronan synthesis by down-regulation of the cellular pool of UDP-N-acetylhexosamines.

Authors: Tiina A Jokela; Marjo Jauhiainen; Seppo Auriola; Miia Kauhanen; Riikka Tiihonen; Markku I Tammi; Raija H Tammi
Journal: J Biol Chem Date: 2008-01-16 Impact factor: 5.157

6. Heart-valve mesenchyme formation is dependent on hyaluronan-augmented activation of ErbB2-ErbB3 receptors.

Authors: Todd D Camenisch; Joyce A Schroeder; Judy Bradley; Scott E Klewer; John A McDonald
Journal: Nat Med Date: 2002-07-22 Impact factor: 53.440

7. Hyaluronan structures synthesized by rat mesangial cells in response to hyperglycemia induce monocyte adhesion.

Authors: Aimin Wang; Vincent C Hascall
Journal: J Biol Chem Date: 2003-12-16 Impact factor: 5.157

8. The cytoplasmic domain of the hyaluronan receptor for endocytosis (HARE) contains multiple endocytic motifs targeting coated pit-mediated internalization.

Authors: Madhu S Pandey; Edward N Harris; Janet A Weigel; Paul H Weigel
Journal: J Biol Chem Date: 2008-06-06 Impact factor: 5.157

9. Regulation of heparan sulfate and chondroitin sulfate glycosaminoglycan biosynthesis by 4-fluoro-glucosamine in murine airway smooth muscle cells.

Authors: Julie Nigro; Aimin Wang; Durba Mukhopadhyay; Mark Lauer; Ronald J Midura; Robert Sackstein; Vincent C Hascall
Journal: J Biol Chem Date: 2009-04-03 Impact factor: 5.157

Review 10. Metabolic control of hyaluronan synthases.

Authors: Davide Vigetti; Manuela Viola; Evgenia Karousou; Giancarlo De Luca; Alberto Passi
Journal: Matrix Biol Date: 2013-10-14 Impact factor: 11.583

48 in total

1. Chondroprotective effects of 4-methylumbelliferone and hyaluronan synthase-2 overexpression involve changes in chondrocyte energy metabolism.

Authors: Kenya Terabe; Yoshifumi Ohashi; Saho Tsuchiya; Shinya Ishizuka; Cheryl B Knudson; Warren Knudson
Journal: J Biol Chem Date: 2019-10-16 Impact factor: 5.157

The dynamic metabolism of hyaluronan regulates the cytosolic concentration of UDP-GlcNAc.

1. Hyaluronan minireview series.

Review 2. Protein O-GlcNAcylation in diabetes and diabetic complications.

Review 3. Hyaluronan catabolism: a new metabolic pathway.

Review 4. Hyaluronan synthases.

5. Mannose inhibits hyaluronan synthesis by down-regulation of the cellular pool of UDP-N-acetylhexosamines.

6. Heart-valve mesenchyme formation is dependent on hyaluronan-augmented activation of ErbB2-ErbB3 receptors.

7. Hyaluronan structures synthesized by rat mesangial cells in response to hyperglycemia induce monocyte adhesion.

8. The cytoplasmic domain of the hyaluronan receptor for endocytosis (HARE) contains multiple endocytic motifs targeting coated pit-mediated internalization.

9. Regulation of heparan sulfate and chondroitin sulfate glycosaminoglycan biosynthesis by 4-fluoro-glucosamine in murine airway smooth muscle cells.

Review 10. Metabolic control of hyaluronan synthases.

1. Chondroprotective effects of 4-methylumbelliferone and hyaluronan synthase-2 overexpression involve changes in chondrocyte energy metabolism.

Review 2. The CD44-HA axis and inflammation in atherosclerosis: A temporal perspective.

3. Physical biology of the cancer cell glycocalyx.

Review 4. Biology and biotechnology of hyaluronan.

Review 5. The journey of hyaluronan research in the Journal of Biological Chemistry.

6. Suppression of murine osteoarthritis by 4-methylumbelliferone.

Review 7. The pericellular hyaluronan of articular chondrocytes.

8. Endorepellin-evoked Autophagy Contributes to Angiostasis.

9. Periostin induces intracellular cross-talk between kinases and hyaluronan in atrioventricular valvulogenesis.

10. Loss of Glycogen Debranching Enzyme AGL Drives Bladder Tumor Growth via Induction of Hyaluronic Acid Synthesis.