Literature DB >> 2448441

NCL-5D3: a new monoclonal antibody recognizing low molecular weight cytokeratins effective for immunohistochemistry using fixed paraffin-embedded tissue.

B Angus1, J Purvis, D Stock, B R Westley, A C Samson, E G Routledge, F H Carpenter, C H Horne.   

Abstract

Production of a new monoclonal antibody designated NCL-5D3 is described. The antibody recognizes several low molecular weight cytokeratins, in particular cytokeratin Moll number 8 as determined by immunoblotting studies, and is highly effective for immunocytochemistry using routinely processed paraffin-embedded material. Staining is enhanced by prior treatment of the sections with trypsin. Assessment using a wide variety of normal and neoplastic tissue indicates reactivity with all tissues of simple or glandular epithelial origin, and in addition with many squamous carcinomas. Thus the antibody should prove of value in diagnostic histopathology.

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Year:  1987        PMID： 2448441     DOI： 10.1002/path.1711530411

Source DB:  PubMed          Journal:  J Pathol        ISSN： 0022-3417            Impact factor:   7.996


  15 in total

1.  Cytokeratin expression and early lens development.

Authors:  M Kasper; C Viebahn
Journal:  Anat Embryol (Berl)       Date:  1992-08

2.  Cytokeratin-immunoreactive cells of human lymph nodes and spleen in normal and pathological conditions. An immunocytochemical study.

Authors:  C Doglioni; P Dell'Orto; G Zanetti; P Iuzzolino; G Coggi; G Viale
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1990

3.  Changes in cytokeratin expression in epidermal keratinocytes during wound healing.

Authors:  S Watanabe; M Osumi; T Ohnishi; E Ichikawa; H Takahashi
Journal:  Histochem Cell Biol       Date:  1995-06       Impact factor: 4.304

4.  Tissue distribution of amyloid P component as defined by a monoclonal antibody produced by immunization with human glomerular basement membranes.

Authors:  H al-Mutlaq; J Wheeler; H Robertson; C Watchorn; A R Morley
Journal:  Histochem J       Date:  1993-03

5.  UNME/K1: an IgG2a monoclonal antibody specific to cytokeratin of human urinary bladder squamous cell carcinoma.

Authors:  H el-Mohamady; M T Basta; M N Seddek; H Helmy; E al-Hilaly; A M Attallah; M A Ghoneim
Journal:  Urol Res       Date:  1991

6.  Patterns of cytokeratin expression by neoplastic and non-neoplastic epithelium.

Authors:  G Mortimer; D N Jones; H Assaf; T al-Ahmadi
Journal:  Ir J Med Sci       Date:  1993-03       Impact factor: 1.568

7.  Cytokeratin expression in non-neoplastic oesophageal epithelium and squamous cell carcinoma of the oesophagus.

Authors:  K Y Lam; S L Loke; X C Shen; L T Ma
Journal:  Virchows Arch       Date:  1995       Impact factor: 4.064

8.  The relationship between flow-cytometric and immunohistochemically detected c-erbB-2 expression, grade and DNA ploidy in breast cancer.

Authors:  I Brotherick; B K Shenton; W K Cowan; B Angus; C H Horne; M J Higgs; T W Lennard
Journal:  Cancer Immunol Immunother       Date:  1995-09       Impact factor: 6.968

9.  p53 expression measured by flow cytometry. A comparison of three monoclonal antibodies and the relationship with grade and DNA ploidy in breast cancer.

Authors:  I Brotherick; B K Shenton; W K Cowan; B Angus; C H Horne; M J Higgs; T W Lennard
Journal:  Cancer Immunol Immunother       Date:  1995-09       Impact factor: 6.968

Review 10.  Clinical relevance associated to the analysis of circulating tumour cells in patients with solid tumours.

Authors:  María José Serrano Fernádez; Juan Carlos Alvarez Merino; Iñigo Martínez Zubiaurre; Ana Fernández García; Pedro Sánchez Rovira; José Antonio Lorente Acosta
Journal:  Clin Transl Oncol       Date:  2009-10       Impact factor: 3.405
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