AIMS: The study explores how speech measures may be linked to language profiles in participants with Alzheimer's disease (AD) and how these profiles could distinguish AD from changes associated with normal aging. METHODS: We analysed simple sentences spoken by older adults with and without AD. Spectrographic analysis of temporal and acoustic characteristics was carried out using the Praat software. RESULTS: We found that measures of speech, such as variations in the percentage of voice breaks, number of periods of voice, number of voice breaks, shimmer (amplitude perturbation quotient), and noise-to-harmonics ratio, characterise people with AD with an accuracy of 84.8%. DISCUSSION: These measures offer a sensitive method of assessing spontaneous speech output in AD, and they discriminate well between people with AD and healthy older adults. This method of evaluation is a promising tool for AD diagnosis and prognosis, and it could be used as a dependent measure in clinical trials.
AIMS: The study explores how speech measures may be linked to language profiles in participants with Alzheimer's disease (AD) and how these profiles could distinguish AD from changes associated with normal aging. METHODS: We analysed simple sentences spoken by older adults with and without AD. Spectrographic analysis of temporal and acoustic characteristics was carried out using the Praat software. RESULTS: We found that measures of speech, such as variations in the percentage of voice breaks, number of periods of voice, number of voice breaks, shimmer (amplitude perturbation quotient), and noise-to-harmonics ratio, characterise people with AD with an accuracy of 84.8%. DISCUSSION: These measures offer a sensitive method of assessing spontaneous speech output in AD, and they discriminate well between people with AD and healthy older adults. This method of evaluation is a promising tool for AD diagnosis and prognosis, and it could be used as a dependent measure in clinical trials.
Authors: Céline De Looze; Amir Dehsarvi; Lisa Crosby; Aisling Vourdanou; Robert F Coen; Brian A Lawlor; Richard B Reilly Journal: Front Aging Neurosci Date: 2021-04-27 Impact factor: 5.750
Authors: Alexandra König; Aharon Satt; Alexander Sorin; Ron Hoory; Orith Toledo-Ronen; Alexandre Derreumaux; Valeria Manera; Frans Verhey; Pauline Aalten; Phillipe H Robert; Renaud David Journal: Alzheimers Dement (Amst) Date: 2015-03-29
Authors: Sabah Al-Hameed; Mohammed Benaissa; Heidi Christensen; Bahman Mirheidari; Daniel Blackburn; Markus Reuber Journal: PLoS One Date: 2019-05-24 Impact factor: 3.240