Literature DB >> 24481042

Methyltransferases modulate RNA stability in embryonic stem cells.

Shuibin Lin1, Richard I Gregory1.   

Abstract

Emerging data support that RNA methylation plays important roles in RNA processing and metabolism. The methyltransferases Mettl3 and Mettl14 are shown to catalyse N(6)-methyladenosine (m(6)A) RNA modification in embryonic stem cells (ESCs). This m(6)A modification controls RNA metabolism and functions to destabilize mRNAs encoding developmental regulators to help sustain ESC self-renewal.

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Year:  2014        PMID： 24481042     DOI： 10.1038/ncb2914

Source DB:  PubMed          Journal:  Nat Cell Biol        ISSN： 1465-7392            Impact factor:   28.824


  13 in total

1.  Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons.

Authors:  Kate D Meyer; Yogesh Saletore; Paul Zumbo; Olivier Elemento; Christopher E Mason; Samie R Jaffrey
Journal:  Cell       Date:  2012-05-17       Impact factor: 41.582

2.  N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells.

Authors:  Yang Wang; Yue Li; Julia I Toth; Matthew D Petroski; Zhaolei Zhang; Jing Crystal Zhao
Journal:  Nat Cell Biol       Date:  2014-01-07       Impact factor: 28.824

3.  Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase.

Authors:  J A Bokar; M E Shambaugh; D Polayes; A G Matera; F M Rottman
Journal:  RNA       Date:  1997-11       Impact factor: 4.942

4.  ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility.

Authors:  Guanqun Zheng; John Arne Dahl; Yamei Niu; Peter Fedorcsak; Chun-Min Huang; Charles J Li; Cathrine B Vågbø; Yue Shi; Wen-Ling Wang; Shu-Hui Song; Zhike Lu; Ralph P G Bosmans; Qing Dai; Ya-Juan Hao; Xin Yang; Wen-Ming Zhao; Wei-Min Tong; Xiu-Jie Wang; Florian Bogdan; Kari Furu; Ye Fu; Guifang Jia; Xu Zhao; Jun Liu; Hans E Krokan; Arne Klungland; Yun-Gui Yang; Chuan He
Journal:  Mol Cell       Date:  2012-11-21       Impact factor: 17.970

5.  The RNA Modification Database, RNAMDB: 2011 update.

Authors:  William A Cantara; Pamela F Crain; Jef Rozenski; James A McCloskey; Kimberly A Harris; Xiaonong Zhang; Franck A P Vendeix; Daniele Fabris; Paul F Agris
Journal:  Nucleic Acids Res       Date:  2010-11-10       Impact factor: 16.971

6.  N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO.

Authors:  Guifang Jia; Ye Fu; Xu Zhao; Qing Dai; Guanqun Zheng; Ying Yang; Chengqi Yi; Tomas Lindahl; Tao Pan; Yun-Gui Yang; Chuan He
Journal:  Nat Chem Biol       Date:  2011-10-16       Impact factor: 15.040

7.  A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation.

Authors:  Jianzhao Liu; Yanan Yue; Dali Han; Xiao Wang; Ye Fu; Liang Zhang; Guifang Jia; Miao Yu; Zhike Lu; Xin Deng; Qing Dai; Weizhong Chen; Chuan He
Journal:  Nat Chem Biol       Date:  2013-12-06       Impact factor: 15.040

8.  High-resolution mapping reveals a conserved, widespread, dynamic mRNA methylation program in yeast meiosis.

Authors:  Schraga Schwartz; Sudeep D Agarwala; Maxwell R Mumbach; Marko Jovanovic; Philipp Mertins; Alexander Shishkin; Yuval Tabach; Tarjei S Mikkelsen; Rahul Satija; Gary Ruvkun; Steven A Carr; Eric S Lander; Gerald R Fink; Aviv Regev
Journal:  Cell       Date:  2013-11-21       Impact factor: 41.582

Review 9.  The bigger picture of FTO: the first GWAS-identified obesity gene.

Authors:  Ruth J F Loos; Giles S H Yeo
Journal:  Nat Rev Endocrinol       Date:  2013-11-19       Impact factor: 43.330

10.  N6-methyladenosine-dependent regulation of messenger RNA stability.

Authors:  Xiao Wang; Zhike Lu; Adrian Gomez; Gary C Hon; Yanan Yue; Dali Han; Ye Fu; Marc Parisien; Qing Dai; Guifang Jia; Bing Ren; Tao Pan; Chuan He
Journal:  Nature       Date:  2013-11-27       Impact factor: 49.962
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  22 in total

1.  Regulation of RNA metabolism is important for in vitro dedifferentiation of plant cells.

Authors:  Misato Ohtani
Journal:  J Plant Res       Date:  2015-02-19       Impact factor: 2.629

2.  NSUN2-Mediated m5C Methylation and METTL3/METTL14-Mediated m6A Methylation Cooperatively Enhance p21 Translation.

Authors:  Qiu Li; Xiu Li; Hao Tang; Bin Jiang; Yali Dou; Myriam Gorospe; Wengong Wang
Journal:  J Cell Biochem       Date:  2017-05-03       Impact factor: 4.429

Review 3.  Deciphering the Epitranscriptomic Signatures in Cell Fate Determination and Development.

Authors:  Varun Haran; Nibedita Lenka
Journal:  Stem Cell Rev Rep       Date:  2019-08       Impact factor: 5.739

4.  m6A modulates neuronal functions and sex determination in Drosophila.

Authors:  Tina Lence; Junaid Akhtar; Marc Bayer; Katharina Schmid; Laura Spindler; Cheuk Hei Ho; Nastasja Kreim; Miguel A Andrade-Navarro; Burkhard Poeck; Mark Helm; Jean-Yves Roignant
Journal:  Nature       Date:  2016-11-30       Impact factor: 49.962

5.  The m(6)A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells.

Authors:  Shuibin Lin; Junho Choe; Peng Du; Robinson Triboulet; Richard I Gregory
Journal:  Mol Cell       Date:  2016-04-21       Impact factor: 17.970

6.  A novel role for DNA methyltransferase 1 in regulating oocyte cytoplasmic maturation in pigs.

Authors:  Yanjun Huan; Bingteng Xie; Shichao Liu; Qingran Kong; Zhonghua Liu
Journal:  PLoS One       Date:  2015-05-26       Impact factor: 3.240

Review 7.  Milk: an epigenetic amplifier of FTO-mediated transcription? Implications for Western diseases.

Authors:  Bodo C Melnik
Journal:  J Transl Med       Date:  2015-12-21       Impact factor: 5.531

8.  N(6)-Methyladenosine: a conformational marker that regulates the substrate specificity of human demethylases FTO and ALKBH5.

Authors:  Shui Zou; Joel D W Toh; Kendra H Q Wong; Yong-Gui Gao; Wanjin Hong; Esther C Y Woon
Journal:  Sci Rep       Date:  2016-05-09       Impact factor: 4.379

9.  The M6A methyltransferase METTL3: acting as a tumor suppressor in renal cell carcinoma.

Authors:  Xiao Li; Jingyuan Tang; Wen Huang; Feng Wang; Pu Li; Chao Qin; Zhiqiang Qin; Qing Zou; Jifu Wei; Lixin Hua; Haiwei Yang; Zengjun Wang
Journal:  Oncotarget       Date:  2017-10-10

10.  N6-Methyladenine hinders RNA- and DNA-directed DNA synthesis: application in human rRNA methylation analysis of clinical specimens.

Authors:  Shaoru Wang; Jiaqi Wang; Xiaoe Zhang; Boshi Fu; Yanyan Song; Pei Ma; Kai Gu; Xin Zhou; Xiaolian Zhang; Tian Tian; Xiang Zhou
Journal:  Chem Sci       Date:  2015-11-17       Impact factor: 9.825
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