Literature DB >> 24479860

1,2,4-triazine analogs as novel class of therapeutic agents.

Rajeev Kumar, T S Sirohi, Hariram Singh, Ramji Yadav, R K Roy, A Chaudhary, S N Pandeya1.   

Abstract

1,2,4-Triazine nucleus is a prominent structural core system present in numerous pharmacologically active compounds. Till date, various 1,2,4-triazine analogs, possesing a wide range of potent pharmacological activities, have been reported. This review is an attempt to compile the medicinal chemistry aspects of various synthesized 1,2,4-triazine analogs reported so far.

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Year:  2014        PMID： 24479860     DOI： 10.2174/1389557514666140131111837

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN： 1389-5575            Impact factor:   3.862


  9 in total

1.  Selective N1/N4 1,4-Cycloaddition of 1,2,4,5-Tetrazines Enabled by Solvent Hydrogen Bonding.

Authors:  Zixi Zhu; Christopher M Glinkerman; Dale L Boger
Journal:  J Am Chem Soc       Date:  2020-11-30       Impact factor: 15.419

2.  Phenylene Bis-Diphenyltriazine (TriAsorB), a new sunfilter protecting the skin against both UVB + UVA and blue light radiations.

Authors:  D Bacqueville; C Jacques-Jamin; H Dromigny; F Boyer; Y Brunel; P J Ferret; D Redoulès; T Douki; S Bessou-Touya; H Duplan
Journal:  Photochem Photobiol Sci       Date:  2021-10-13       Impact factor: 3.982

3.  N1/N4 1,4-Cycloaddition of 1,2,4,5-Tetrazines with Enamines Promoted by the Lewis Acid ZnCl2.

Authors:  Zixi Zhu; Dale L Boger
Journal:  J Org Chem       Date:  2022-04-13       Impact factor: 4.198

4.  1,2,4-Triazine Sulfonamides: Synthesis by Sulfenamide Intermediates, In Vitro Anticancer Screening, Structural Characterization, and Molecular Docking Study.

Authors:  Danuta Branowska; Zbigniew Karczmarzyk; Ewa Wolińska; Waldemar Wysocki; Maja Morawiak; Zofia Urbańczyk-Lipkowska; Anna Bielawska; Krzysztof Bielawski
Journal:  Molecules       Date:  2020-05-16       Impact factor: 4.411

5.  The Effect of Novel 7-methyl-5-phenyl-pyrazolo[4,3-e]tetrazolo[4,5-b][1,2,4]triazine Sulfonamide Derivatives on Apoptosis and Autophagy in DLD-1 and HT-29 Colon Cancer Cells.

Authors:  Agnieszka Gornowicz; Anna Szymanowska; Mariusz Mojzych; Krzysztof Bielawski; Anna Bielawska
Journal:  Int J Mol Sci       Date:  2020-07-23       Impact factor: 5.923

6.  Exploration of novel heterofused 1,2,4-triazine derivative in colorectal cancer.

Authors:  Justyna Magdalena Hermanowicz; Anna Szymanowska; Beata Sieklucka; Robert Czarnomysy; Krystyna Pawlak; Anna Bielawska; Krzysztof Bielawski; Joanna Kalafut; Alicja Przybyszewska; Arkadiusz Surazynski; Adolfo Rivero-Muller; Mariusz Mojzych; Dariusz Pawlak
Journal:  J Enzyme Inhib Med Chem       Date:  2021-12       Impact factor: 5.051

7.  Pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine Sulfonamides as Novel Potential Anticancer Agents: Cytotoxic and Genotoxic Activities In Vitro.

Authors:  Karol Bukowski; Beata Marciniak; Mateusz Kciuk; Mariusz Mojzych; Renata Kontek
Journal:  Molecules       Date:  2022-06-11       Impact factor: 4.927

8.  General Synthesis of 1-Aryl-6-azaisocytosines and Their Utilization for the Preparation of Related Condensed 1,2,4-Triazines.

Authors:  František Zálešák; Jan Slouka; Jakub Stýskala
Journal:  Molecules       Date:  2019-10-01       Impact factor: 4.411

9.  Two New Compounds Containing Pyridinone or Triazine Heterocycles Have Antifungal Properties against Candida albicans.

Authors:  Laura Mena; Muriel Billamboz; Rogatien Charlet; Bérangère Desprès; Boualem Sendid; Alina Ghinet; Samir Jawhara
Journal:  Antibiotics (Basel)       Date:  2022-01-08
  9 in total

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