Stephanie L Garrett1, Patricia Sawyer2,3, Richard E Kennedy3, Dawn McGuire4, Roger P Simon5,6,7, Harry S Strothers8, Richard M Allman3,9,10,11. 1. Department of Family Medicine, National Center for Primary Care, Morehouse School of Medicine, Atlanta, Georgia. 2. Comprehensive Center for Healthy Aging, Gerontology Education Program, University of Alabama at Birmingham, Birmingham, Alabama. 3. Division of Gerontology, Geriatrics, and Palliative Care, University of Alabama at Birmingham, Birmingham, Alabama. 4. Neuroscience Institute, Morehouse School of Medicine, Atlanta, Georgia. 5. Translational Programs in Stroke, Morehouse School of Medicine, Atlanta, Georgia. 6. Department of Medicine (Neurology), Morehouse School of Medicine, Atlanta, Georgia. 7. Department of Neurobiology, Morehouse School of Medicine, Atlanta, Georgia. 8. Department of Family Medicine, Morehouse School of Medicine, Atlanta, Georgia. 9. Birmingham/Atlanta Veterans Affairs Geriatric Research, Education, and Clinical Center, Birmingham, Alabama. 10. Comprehensive Center for Healthy Aging, Deep South Resource Center for Minority Aging Research, University of Alabama at Birmingham, Birmingham, Alabama. 11. Southeast Center of Excellence in Geriatric Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Abstract
OBJECTIVES: To examine the association between function measured according to activities of daily living (ADLs), instrumental activ1ities of daily living (IADLs), and cognition assessed according to Mini-Mental State Examination (MMSE) scores of older African-American and non-Hispanic white community-dwelling men and women. DESIGN: Cross-sectional study assessing associations between self-reported ADL and IADL difficulty and MMSE scores for race- and sex-specific groups. SETTING: Homes of community-dwelling older adults. PARTICIPANTS: A random sample of 974 African-American and non-Hispanic white Medicare beneficiaries aged 65 and older living in west-central Alabama and participating in the University of Alabama at Birmingham Study of Aging, excluding those with reported diagnoses of dementia or with missing data. MEASUREMENTS: Function, based on self-reported difficulty in performing ADLs and IADLs, and cognition, using the MMSE. Multivariable linear regression models were used to test the association between function and cognition in race- and sex-specific groups after adjusting for covariates. RESULTS: Mini-Mental State Examination scores were modestly correlated with ADL and IADL difficulty in all four race- and sex-specific groups, with Pearson correlation coefficients ranging from −0.189 for non-Hispanic white women to −0.429 for African-American men. Correlations between MMSE and ADL or IADL difficulty in any of the race- and sex-specific groups were no longer significant after controlling for sociodemographic factors and comorbidities. CONCLUSION: Mini-Mental State Examination was not significantly associated with functional difficulty in older African-American and non-Hispanic white men and women after adjusting for sociodemographic factors and comorbidities, suggesting a mediating role in the relationship between cognition and function.
OBJECTIVES: To examine the association between function measured according to activities of daily living (ADLs), instrumental activ1ities of daily living (IADLs), and cognition assessed according to Mini-Mental State Examination (MMSE) scores of older African-American and non-Hispanic white community-dwelling men and women. DESIGN: Cross-sectional study assessing associations between self-reported ADL and IADL difficulty and MMSE scores for race- and sex-specific groups. SETTING: Homes of community-dwelling older adults. PARTICIPANTS: A random sample of 974 African-American and non-Hispanic white Medicare beneficiaries aged 65 and older living in west-central Alabama and participating in the University of Alabama at Birmingham Study of Aging, excluding those with reported diagnoses of dementia or with missing data. MEASUREMENTS: Function, based on self-reported difficulty in performing ADLs and IADLs, and cognition, using the MMSE. Multivariable linear regression models were used to test the association between function and cognition in race- and sex-specific groups after adjusting for covariates. RESULTS: Mini-Mental State Examination scores were modestly correlated with ADL and IADL difficulty in all four race- and sex-specific groups, with Pearson correlation coefficients ranging from −0.189 for non-Hispanic white women to −0.429 for African-American men. Correlations between MMSE and ADL or IADL difficulty in any of the race- and sex-specific groups were no longer significant after controlling for sociodemographic factors and comorbidities. CONCLUSION: Mini-Mental State Examination was not significantly associated with functional difficulty in older African-American and non-Hispanic white men and women after adjusting for sociodemographic factors and comorbidities, suggesting a mediating role in the relationship between cognition and function.
Authors: Alden L Gross; Qian-Li Xue; Karen Bandeen-Roche; Linda P Fried; Ravi Varadhan; Mara A McAdams-DeMarco; Jeremy Walston; Michelle C Carlson Journal: J Gerontol A Biol Sci Med Sci Date: 2016-04-15 Impact factor: 6.053
Authors: Mary N Haan; Anne Lee; Michelle C Odden; Allison E Aiello; Tu My To; John M Neuhaus Journal: J Gerontol A Biol Sci Med Sci Date: 2016-02-17 Impact factor: 6.053
Authors: Stephanie L Garrett; Richard E Kennedy; Patricia Sawyer; Courtney P Williams; Cynthia J Brown; Richard M Allman Journal: J Natl Med Assoc Date: 2018-12-04 Impact factor: 1.798