Xin Li1, Chao Ma1, Junying Zhang1, Ying Liang1, Yaojing Chen1, Kewei Chen2, Jun Wang1, Zhanjun Zhang1, Yongyan Wang3. 1. State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China. 2. Department of Psychiatry, Banner Alzheimer's Institute, Phoenix, Arizona. 3. Institute of Basic Research in Clinical Medicine, China Academy of Traditional Chinese Medicine, Beijing, China.
Abstract
OBJECTIVES: To estimate the prevalence of mild cognitive impairment (MCI) in Beijing, China, and to explore the potential protective and risk factors for MCI. DESIGN: Population-based survey. SETTING: The Beijing Ageing Brain Rejuvenation Initiative (BABRI). PARTICIPANTS: Participants randomly recruited from BABRI (N=1,211). MEASUREMENTS: Participants underwent a battery of neuropsychological examinations to determine cognitive function and answered a series of personal questions. The prevalence of MCI and its subtypes were computed using Petersen's criteria. Influencing factors for MCI were estimated based on participant medical history, lifestyle, diet, and leisure activities. RESULTS: One thousand twenty (aged>55, mean 63.9±6.6; 36.7% male) subjects completed the neuropsychological tests. The overall prevalence of MCI was 15.7%, with single-domain amnestic, multiple-domain amnestic, and nonamnestic subtype prevalences of 6.4%, 3.7%, and 5.6%, respectively. Eight hundred sixty-four subjects were used for the case–control analysis. Hypertension, diabetes mellitus, and cerebrovascular disease were found to be associated with MCI. Healthy diet and greater involvement in physical, intellectual, and social activities were associated with a lower risk of MCI. CONCLUSION: The prevalence of MCI was compatible with that found in previous published reports, and the information on the epidemiology of MCI, especially risk factors, may help to explore therapeutic strategies and preventive approaches to delay conversion to dementia.
OBJECTIVES: To estimate the prevalence of mild cognitive impairment (MCI) in Beijing, China, and to explore the potential protective and risk factors for MCI. DESIGN: Population-based survey. SETTING: The Beijing Ageing Brain Rejuvenation Initiative (BABRI). PARTICIPANTS: Participants randomly recruited from BABRI (N=1,211). MEASUREMENTS: Participants underwent a battery of neuropsychological examinations to determine cognitive function and answered a series of personal questions. The prevalence of MCI and its subtypes were computed using Petersen's criteria. Influencing factors for MCI were estimated based on participant medical history, lifestyle, diet, and leisure activities. RESULTS: One thousand twenty (aged>55, mean 63.9±6.6; 36.7% male) subjects completed the neuropsychological tests. The overall prevalence of MCI was 15.7%, with single-domain amnestic, multiple-domain amnestic, and nonamnestic subtype prevalences of 6.4%, 3.7%, and 5.6%, respectively. Eight hundred sixty-four subjects were used for the case–control analysis. Hypertension, diabetes mellitus, and cerebrovascular disease were found to be associated with MCI. Healthy diet and greater involvement in physical, intellectual, and social activities were associated with a lower risk of MCI. CONCLUSION: The prevalence of MCI was compatible with that found in previous published reports, and the information on the epidemiology of MCI, especially risk factors, may help to explore therapeutic strategies and preventive approaches to delay conversion to dementia.
Authors: Ronald C Petersen; Oscar Lopez; Melissa J Armstrong; Thomas S D Getchius; Mary Ganguli; David Gloss; Gary S Gronseth; Daniel Marson; Tamara Pringsheim; Gregory S Day; Mark Sager; James Stevens; Alexander Rae-Grant Journal: Neurology Date: 2017-12-27 Impact factor: 9.910