Xin Li1,2, Chao Ma1,2, Xuan Sun2, Junying Zhang1,2, Yaojing Chen1,2, Kewei Chen2,3, Zhanjun Zhang4,5. 1. State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875, People's Republic of China. 2. BABRI Centre, Beijing Normal University, Beijing, 100875, People's Republic of China. 3. Banner Alzheimer's Institute, Phoenix, AZ, 85006, USA. 4. State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875, People's Republic of China. zhang_rzs@bnu.edu.cn. 5. BABRI Centre, Beijing Normal University, Beijing, 100875, People's Republic of China. zhang_rzs@bnu.edu.cn.
Abstract
OBJECTIVES: Hypertension is considered a risk factor of cognitive impairments and could result in white matter changes. Current studies on hypertension-related white matter (WM) changes focus only on regional changes, and the information about global changes in WM structure network is limited. METHODS: We assessed the cognitive function in 39 hypertensive patients and 37 healthy controls with a battery of neuropsychological tests. The WM structural networks were constructed by utilizing diffusion tensor tractography and calculated topological properties of the networks using a graph theoretical method. The direct and indirect correlations among cognitive impairments, brain WM network disruptions and hypertension were analyzed with structural equation modelling (SEM). RESULTS: Hypertensive patients showed deficits in executive function, memory and attention compared with controls. An aberrant connectivity of WM networks was found in the hypertensive patients (P Eglob = 0.005, P Lp = 0.005), especially in the frontal and parietal regions. Importantly, SEM analysis showed that the decline of executive function resulted from aberrant WM networks in hypertensive patients (p = 0.3788, CFI = 0.99). CONCLUSIONS: These results suggest that the cognitive decline in hypertensive patients was due to frontal and parietal WM disconnections. Our findings highlight the importance of brain protection in hypertension patients. KEY POINTS: • Hypertension has a negative effect on the performance of the cognitive domains • Reduced efficiencies of white matter networks were shown in hypertension • Disrupted white matter networks are responsible for poor cognitive function in hypertension.
OBJECTIVES:Hypertension is considered a risk factor of cognitive impairments and could result in white matter changes. Current studies on hypertension-related white matter (WM) changes focus only on regional changes, and the information about global changes in WM structure network is limited. METHODS: We assessed the cognitive function in 39 hypertensivepatients and 37 healthy controls with a battery of neuropsychological tests. The WM structural networks were constructed by utilizing diffusion tensor tractography and calculated topological properties of the networks using a graph theoretical method. The direct and indirect correlations among cognitive impairments, brain WM network disruptions and hypertension were analyzed with structural equation modelling (SEM). RESULTS:Hypertensivepatients showed deficits in executive function, memory and attention compared with controls. An aberrant connectivity of WM networks was found in the hypertensivepatients (P Eglob = 0.005, P Lp = 0.005), especially in the frontal and parietal regions. Importantly, SEM analysis showed that the decline of executive function resulted from aberrant WM networks in hypertensivepatients (p = 0.3788, CFI = 0.99). CONCLUSIONS: These results suggest that the cognitive decline in hypertensivepatients was due to frontal and parietal WM disconnections. Our findings highlight the importance of brain protection in hypertensionpatients. KEY POINTS: • Hypertension has a negative effect on the performance of the cognitive domains • Reduced efficiencies of white matter networks were shown in hypertension • Disrupted white matter networks are responsible for poor cognitive function in hypertension.
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