Literature DB >> 2447530

Co-release of acetylcholine, glutamate and taurine from synaptosomes of Torpedo electric organ.

S Vyas1, H F Bradford.   

Abstract

The amino acid content of Torpedo synaptosomes was investigated. It was found that glutamate and taurine were particularly enriched, their concentration exceeding that of acetylcholine by 50-60%. Other amino acids such as alanine, gamma-aminobutyric acid (GABA), glycine, leucine and phenylalanine were also present, but in smaller quantities. The neurotransmitter-releasing agents gramicidin, calcium ionophore A23187, High K+ and Glycera venom all released acetylcholine, as shown previously. However, both glutamate and taurine were found to be released by these agents together with acetylcholine. The efflux of all 3 compounds was found to be largely calcium dependent.

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Year:  1987        PMID： 2447530     DOI： 10.1016/0304-3940(87)90171-6

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  10 in total

1.  The effects of glutamate on spontaneous acetylcholine secretion processes in the rat neuromuscular synapse.

Authors:  A I Malomuzh; M R Mukhtarov; A Kh Urazaev; E E Nikol'skii; F Vyskochil
Journal:  Neurosci Behav Physiol       Date:  2002 Nov-Dec

2.  The immunolysis, isolation, and properties of subpopulations of mammalian brain synaptosomes.

Authors:  H F Bradford; M Docherty; J Y Wu; C D Cash; M Ehret; M Maitre; T H Joh
Journal:  Neurochem Res       Date:  1989-04       Impact factor: 3.996

3.  Potentiation of neurotransmitter release by activation of presynaptic glutamate receptors at developing neuromuscular synapses of Xenopus.

Authors:  W M Fu; J C Liou; Y H Lee; H C Liou
Journal:  J Physiol       Date:  1995-12-15       Impact factor: 5.182

4.  Isolation of metabolically distinct synaptosomes on Percoll gradients.

Authors:  A D Sherman
Journal:  Neurochem Res       Date:  1989-01       Impact factor: 3.996

5.  Acetylcholine secretion enhanced by glutamate in rat embryonic spinal motoneurons: respective involvement of NMDA and AMPA receptors.

Authors:  M Barthélémy-Requin; P Portalier; M C Chamoin; J P Ternaux
Journal:  Neurochem Res       Date:  2000-03       Impact factor: 3.996

6.  Vesicular glutamate transporter 1 immunoreactivity in extrinsic and intrinsic innervation of the rat esophagus.

Authors:  P Ewald; W L Neuhuber; M Raab
Journal:  Histochem Cell Biol       Date:  2005-10-18       Impact factor: 4.304

7.  Regulation of presynaptic NMDA responses by external and intracellular pH changes at developing neuromuscular synapses.

Authors:  Y H Chen; M L Wu; W M Fu
Journal:  J Neurosci       Date:  1998-04-15       Impact factor: 6.167

8.  Demonstration of glutamate-like immunoreactivity at rat neuromuscular junctions by quantitative electron microscopic immunocytochemistry.

Authors:  O Waerhaug; O P Ottersen
Journal:  Anat Embryol (Berl)       Date:  1993-11

9.  Functional limb muscle innervation prior to cholinergic transmitter specification during early metamorphosis in Xenopus.

Authors:  Francois M Lambert; Laura Cardoit; Elric Courty; Marion Bougerol; Muriel Thoby-Brisson; John Simmers; Hervé Tostivint; Didier Le Ray
Journal:  Elife       Date:  2018-05-30       Impact factor: 8.140

10.  Individual synaptic vesicles from the electroplaque of Torpedo californica, a classic cholinergic synapse, also contain transporters for glutamate and ATP.

Authors:  Huinan Li; Mark L Harlow
Journal:  Physiol Rep       Date:  2014-01-28
  10 in total

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