| Literature DB >> 12469883 |
A I Malomuzh1, M R Mukhtarov, A Kh Urazaev, E E Nikol'skii, F Vyskochil.
Abstract
Experiments on rat diaphragm muscles showed that glutamate (10 microM-1 mM) had no effect on the mean frequency, interspike intervals, and amplitude-time characteristics of miniature endplate potentials, but had a suppressive action on non-quantum secretion (the intensity of which was assessed in terms of the H effect). The effect of glutamate was markedly concentration-dependent and was completely overcome by blockade of NMDA receptors, inhibition of NO synthase, and by binding of NO molecules in the extracellular space by hemoglobin. It is suggested that glutamate can modulate the non-quantum release of acetylcholine, initiating the synthesis of NO molecules in muscle fibers via activation of NMDA receptors followed by the retrograde action of NO on nerve terminals.Entities:
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Year: 2002 PMID： 12469883 DOI： 10.1023/a:1020497308865
Source DB: PubMed Journal: Neurosci Behav Physiol ISSN： 0097-0549