Literature DB >> 24474688

Evidence of native α-synuclein conformers in the human brain.

Neal Gould1, Danielle E Mor, Richard Lightfoot, Kristen Malkus, Benoit Giasson, Harry Ischiropoulos.   

Abstract

α-Synuclein aggregation is central to the pathogenesis of several brain disorders. However, the native conformations and functions of this protein in the human brain are not precisely known. The native state of α-synuclein was probed by gel filtration coupled with native gradient gel separation, an array of antibodies with non-overlapping epitopes, and mass spectrometry. The existence of metastable conformers and stable monomer was revealed in the human brain.

Entities:  

Keywords:  Alpha-Synuclein; Human Brain; Native State; Neurodegenerative Diseases; Parkinson Disease; Protein Conformation; Protein Folding

Mesh：

Substances：

Year:  2014        PMID： 24474688      PMCID： PMC3953303          DOI： 10.1074/jbc.C113.538249

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  35 in total

1.  A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly.

Authors:  B I Giasson; I V Murray; J Q Trojanowski; V M Lee
Journal:  J Biol Chem       Date:  2000-11-01       Impact factor: 5.157

2.  Chaperone-like activity of synucleins.

Authors:  J M Souza; B I Giasson; V M Lee; H Ischiropoulos
Journal:  FEBS Lett       Date:  2000-05-26       Impact factor: 4.124

3.  Attenuation of dopamine transporter activity by alpha-synuclein.

Authors:  Christophe Wersinger; Anita Sidhu
Journal:  Neurosci Lett       Date:  2003-04-17       Impact factor: 3.046

4.  Lipid droplet binding and oligomerization properties of the Parkinson's disease protein alpha-synuclein.

Authors:  Nelson B Cole; Diane D Murphy; Theresa Grider; Susan Rueter; Dawn Brasaemle; Robert L Nussbaum
Journal:  J Biol Chem       Date:  2001-12-14       Impact factor: 5.157

5.  Biophysical properties of the synucleins and their propensities to fibrillate: inhibition of alpha-synuclein assembly by beta- and gamma-synucleins.

Authors:  Vladimir N Uversky; Jie Li; Pierre Souillac; Ian S Millett; Sebastian Doniach; Ross Jakes; Michel Goedert; Anthony L Fink
Journal:  J Biol Chem       Date:  2002-01-25       Impact factor: 5.157

6.  A panel of epitope-specific antibodies detects protein domains distributed throughout human alpha-synuclein in Lewy bodies of Parkinson's disease.

Authors:  B I Giasson; R Jakes; M Goedert; J E Duda; S Leight; J Q Trojanowski; V M Lee
Journal:  J Neurosci Res       Date:  2000-02-15       Impact factor: 4.164

7.  Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha -synuclein in human and transgenic mouse brain.

Authors:  P J Kahle; M Neumann; L Ozmen; V Muller; H Jacobsen; A Schindzielorz; M Okochi; U Leimer; H van Der Putten; A Probst; E Kremmer; H A Kretzschmar; C Haass
Journal:  J Neurosci       Date:  2000-09-01       Impact factor: 6.167

8.  Alpha-Synuclein is degraded by both autophagy and the proteasome.

Authors:  Julie L Webb; Brinda Ravikumar; Jane Atkins; Jeremy N Skepper; David C Rubinsztein
Journal:  J Biol Chem       Date:  2003-04-28       Impact factor: 5.157

9.  Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct.

Authors:  K A Conway; J C Rochet; R M Bieganski; P T Lansbury
Journal:  Science       Date:  2001-11-09       Impact factor: 47.728

10.  Properties of native brain α-synuclein.

Authors:  Jacqueline Burré; Sandro Vivona; Jiajie Diao; Manu Sharma; Axel T Brunger; Thomas C Südhof
Journal:  Nature       Date:  2013-06-13       Impact factor: 49.962
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  27 in total

Review 1.  Dynamic structural flexibility of α-synuclein.

Authors:  Danielle E Mor; Scott E Ugras; Malcolm J Daniels; Harry Ischiropoulos
Journal:  Neurobiol Dis       Date:  2015-12-31       Impact factor: 5.996

Review 2.  Dynamic behaviors of α-synuclein and tau in the cellular context: New mechanistic insights and therapeutic opportunities in neurodegeneration.

Authors:  Fred Yeboah; Tae-Eun Kim; Anke Bill; Ulf Dettmer
Journal:  Neurobiol Dis       Date:  2019-07-24       Impact factor: 5.996

Review 3.  The usual suspects, dopamine and alpha-synuclein, conspire to cause neurodegeneration.

Authors:  Danielle E Mor; Malcolm J Daniels; Harry Ischiropoulos
Journal:  Mov Disord       Date:  2019-01-11       Impact factor: 10.338

4.  α-synuclein multimers cluster synaptic vesicles and attenuate recycling.

Authors:  Lina Wang; Utpal Das; David A Scott; Yong Tang; Pamela J McLean; Subhojit Roy
Journal:  Curr Biol       Date:  2014-09-25       Impact factor: 10.834

Review 5.  Targeting α-synuclein for treatment of Parkinson's disease: mechanistic and therapeutic considerations.

Authors:  Benjamin Dehay; Mathieu Bourdenx; Philippe Gorry; Serge Przedborski; Miquel Vila; Stephane Hunot; Andrew Singleton; C Warren Olanow; Kalpana M Merchant; Erwan Bezard; Gregory A Petsko; Wassilios G Meissner
Journal:  Lancet Neurol       Date:  2015-06-03       Impact factor: 44.182

6.  Individual Amino Acid Supplementation Can Improve Energy Metabolism and Decrease ROS Production in Neuronal Cells Overexpressing Alpha-Synuclein.

Authors:  Vedad Delic; Jeddidiah W D Griffin; Sandra Zivkovic; Yumeng Zhang; Tam-Anh Phan; Henry Gong; Dale Chaput; Christian Reynes; Vinh B Dinh; Josean Cruz; Eni Cvitkovic; Devon Placides; Ernide Frederic; Hamed Mirzaei; Stanley M Stevens; Umesh Jinwal; Daniel C Lee; Patrick C Bradshaw
Journal:  Neuromolecular Med       Date:  2017-06-15       Impact factor: 3.843

7.  Loss of native α-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells.

Authors:  Ulf Dettmer; Nagendran Ramalingam; Victoria E von Saucken; Tae-Eun Kim; Andrew J Newman; Elizabeth Terry-Kantor; Silke Nuber; Maria Ericsson; Saranna Fanning; Tim Bartels; Susan Lindquist; Oren A Levy; Dennis Selkoe
Journal:  Hum Mol Genet       Date:  2017-09-15       Impact factor: 6.150

Review 8.  α-Synuclein Misfolding Versus Aggregation Relevance to Parkinson's Disease: Critical Assessment and Modeling.

Authors:  Ruben Berrocal; Velmarini Vasquez; Sambasiva Rao Krs; Bharathi S Gadad; K S Rao
Journal:  Mol Neurobiol       Date:  2014-08-20       Impact factor: 5.590

9.  KTKEGV repeat motifs are key mediators of normal α-synuclein tetramerization: Their mutation causes excess monomers and neurotoxicity.

Authors:  Ulf Dettmer; Andrew J Newman; Victoria E von Saucken; Tim Bartels; Dennis Selkoe
Journal:  Proc Natl Acad Sci U S A       Date:  2015-07-07       Impact factor: 11.205

10.  From a Highly Disordered to a Metastable State: Uncovering Insights of α-Synuclein.

Authors:  Yoann Cote; Patrice Delarue; Harold A Scheraga; Patrick Senet; Gia G Maisuradze
Journal:  ACS Chem Neurosci       Date:  2018-02-26       Impact factor: 4.418
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