Literature DB >> 24473321

A cistrome roadmap for understanding pancreatic islet biology.

Dana Avrahami1, Klaus H Kaestner1.   

Abstract

Although dozens of common variants have been associated with increased risk of type 2 diabetes (T2D), the mechanisms by which these variants increase disease susceptibility are largely unknown. A new study mapping the human pancreatic islet cistrome provides a roadmap for exploring the effects of these variants and suggests that altered enhancer function might be a common contributor to the genetic risk of T2D.

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Year:  2014        PMID： 24473321      PMCID： PMC5351417          DOI： 10.1038/ng.2880

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  11 in total

Review 1.  Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeover.

Authors:  Roger H Unger; Alan D Cherrington
Journal:  J Clin Invest       Date:  2012-01-03       Impact factor: 14.808

2.  Transcriptomes of the major human pancreatic cell types.

Authors:  C Dorrell; J Schug; C F Lin; P S Canaday; A J Fox; O Smirnova; R Bonnah; P R Streeter; C J Stoeckert; K H Kaestner; M Grompe
Journal:  Diabetologia       Date:  2011-09-01       Impact factor: 10.122

3.  Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes.

Authors:  Jenny E Gunton; Rohit N Kulkarni; SunHee Yim; Terumasa Okada; Wayne J Hawthorne; Yu-Hua Tseng; Russell S Roberson; Camillo Ricordi; Philip J O'Connell; Frank J Gonzalez; C Ronald Kahn
Journal:  Cell       Date:  2005-08-12       Impact factor: 41.582

4.  Assessment of human pancreatic islet architecture and composition by laser scanning confocal microscopy.

Authors:  Marcela Brissova; Michael J Fowler; Wendell E Nicholson; Anita Chu; Boaz Hirshberg; David M Harlan; Alvin C Powers
Journal:  J Histochem Cytochem       Date:  2005-05-27       Impact factor: 2.479

5.  Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.

Authors:  Benjamin F Voight; Laura J Scott; Valgerdur Steinthorsdottir; Andrew P Morris; Christian Dina; Ryan P Welch; Eleftheria Zeggini; Cornelia Huth; Yurii S Aulchenko; Gudmar Thorleifsson; Laura J McCulloch; Teresa Ferreira; Harald Grallert; Najaf Amin; Guanming Wu; Cristen J Willer; Soumya Raychaudhuri; Steve A McCarroll; Claudia Langenberg; Oliver M Hofmann; Josée Dupuis; Lu Qi; Ayellet V Segrè; Mandy van Hoek; Pau Navarro; Kristin Ardlie; Beverley Balkau; Rafn Benediktsson; Amanda J Bennett; Roza Blagieva; Eric Boerwinkle; Lori L Bonnycastle; Kristina Bengtsson Boström; Bert Bravenboer; Suzannah Bumpstead; Noisël P Burtt; Guillaume Charpentier; Peter S Chines; Marilyn Cornelis; David J Couper; Gabe Crawford; Alex S F Doney; Katherine S Elliott; Amanda L Elliott; Michael R Erdos; Caroline S Fox; Christopher S Franklin; Martha Ganser; Christian Gieger; Niels Grarup; Todd Green; Simon Griffin; Christopher J Groves; Candace Guiducci; Samy Hadjadj; Neelam Hassanali; Christian Herder; Bo Isomaa; Anne U Jackson; Paul R V Johnson; Torben Jørgensen; Wen H L Kao; Norman Klopp; Augustine Kong; Peter Kraft; Johanna Kuusisto; Torsten Lauritzen; Man Li; Aloysius Lieverse; Cecilia M Lindgren; Valeriya Lyssenko; Michel Marre; Thomas Meitinger; Kristian Midthjell; Mario A Morken; Narisu Narisu; Peter Nilsson; Katharine R Owen; Felicity Payne; John R B Perry; Ann-Kristin Petersen; Carl Platou; Christine Proença; Inga Prokopenko; Wolfgang Rathmann; N William Rayner; Neil R Robertson; Ghislain Rocheleau; Michael Roden; Michael J Sampson; Richa Saxena; Beverley M Shields; Peter Shrader; Gunnar Sigurdsson; Thomas Sparsø; Klaus Strassburger; Heather M Stringham; Qi Sun; Amy J Swift; Barbara Thorand; Jean Tichet; Tiinamaija Tuomi; Rob M van Dam; Timon W van Haeften; Thijs van Herpt; Jana V van Vliet-Ostaptchouk; G Bragi Walters; Michael N Weedon; Cisca Wijmenga; Jacqueline Witteman; Richard N Bergman; Stephane Cauchi; Francis S Collins; Anna L Gloyn; Ulf Gyllensten; Torben Hansen; Winston A Hide; Graham A Hitman; Albert Hofman; David J Hunter; Kristian Hveem; Markku Laakso; Karen L Mohlke; Andrew D Morris; Colin N A Palmer; Peter P Pramstaller; Igor Rudan; Eric Sijbrands; Lincoln D Stein; Jaakko Tuomilehto; Andre Uitterlinden; Mark Walker; Nicholas J Wareham; Richard M Watanabe; Gonçalo R Abecasis; Bernhard O Boehm; Harry Campbell; Mark J Daly; Andrew T Hattersley; Frank B Hu; James B Meigs; James S Pankow; Oluf Pedersen; H-Erich Wichmann; Inês Barroso; Jose C Florez; Timothy M Frayling; Leif Groop; Rob Sladek; Unnur Thorsteinsdottir; James F Wilson; Thomas Illig; Philippe Froguel; Cornelia M van Duijn; Kari Stefansson; David Altshuler; Michael Boehnke; Mark I McCarthy
Journal:  Nat Genet       Date:  2010-07       Impact factor: 38.330

Review 6.  Transcriptional and epigenetic regulation in human islets.

Authors:  Nuria C Bramswig; Klaus H Kaestner
Journal:  Diabetologia       Date:  2013-12-21       Impact factor: 10.122

7.  Epigenetic regulation of the DLK1-MEG3 microRNA cluster in human type 2 diabetic islets.

Authors:  Vasumathi Kameswaran; Nuria C Bramswig; Lindsay B McKenna; Melinda Penn; Jonathan Schug; Nicholas J Hand; Ying Chen; Inchan Choi; Anastassios Vourekas; Kyoung-Jae Won; Chengyang Liu; Kumar Vivek; Ali Naji; Joshua R Friedman; Klaus H Kaestner
Journal:  Cell Metab       Date:  2013-12-26       Impact factor: 27.287

8.  Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians.

Authors:  Yoon Shin Cho; Chien-Hsiun Chen; Cheng Hu; Jirong Long; Rick Twee Hee Ong; Xueling Sim; Fumihiko Takeuchi; Ying Wu; Min Jin Go; Toshimasa Yamauchi; Yi-Cheng Chang; Soo Heon Kwak; Ronald C W Ma; Ken Yamamoto; Linda S Adair; Tin Aung; Qiuyin Cai; Li-Ching Chang; Yuan-Tsong Chen; Yutang Gao; Frank B Hu; Hyung-Lae Kim; Sangsoo Kim; Young Jin Kim; Jeannette Jen-Mai Lee; Nanette R Lee; Yun Li; Jian Jun Liu; Wei Lu; Jiro Nakamura; Eitaro Nakashima; Daniel Peng-Keat Ng; Wan Ting Tay; Fuu-Jen Tsai; Tien Yin Wong; Mitsuhiro Yokota; Wei Zheng; Rong Zhang; Congrong Wang; Wing Yee So; Keizo Ohnaka; Hiroshi Ikegami; Kazuo Hara; Young Min Cho; Nam H Cho; Tien-Jyun Chang; Yuqian Bao; Åsa K Hedman; Andrew P Morris; Mark I McCarthy; Ryoichi Takayanagi; Kyong Soo Park; Weiping Jia; Lee-Ming Chuang; Juliana C N Chan; Shiro Maeda; Takashi Kadowaki; Jong-Young Lee; Jer-Yuarn Wu; Yik Ying Teo; E Shyong Tai; Xiao Ou Shu; Karen L Mohlke; Norihiro Kato; Bok-Ghee Han; Mark Seielstad
Journal:  Nat Genet       Date:  2011-12-11       Impact factor: 38.330

9.  Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants.

Authors:  Lorenzo Pasquali; Kyle J Gaulton; Santiago A Rodríguez-Seguí; Loris Mularoni; Irene Miguel-Escalada; İldem Akerman; Juan J Tena; Ignasi Morán; Carlos Gómez-Marín; Martijn van de Bunt; Joan Ponsa-Cobas; Natalia Castro; Takao Nammo; Inês Cebola; Javier García-Hurtado; Miguel Angel Maestro; François Pattou; Lorenzo Piemonti; Thierry Berney; Anna L Gloyn; Philippe Ravassard; José Luis Gómez Skarmeta; Ferenc Müller; Mark I McCarthy; Jorge Ferrer
Journal:  Nat Genet       Date:  2014-01-12       Impact factor: 38.330

10.  Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.

Authors:  Andrew P Morris; Benjamin F Voight; Tanya M Teslovich; Teresa Ferreira; Ayellet V Segrè; Valgerdur Steinthorsdottir; Rona J Strawbridge; Hassan Khan; Harald Grallert; Anubha Mahajan; Inga Prokopenko; Hyun Min Kang; Christian Dina; Tonu Esko; Ross M Fraser; Stavroula Kanoni; Ashish Kumar; Vasiliki Lagou; Claudia Langenberg; Jian'an Luan; Cecilia M Lindgren; Martina Müller-Nurasyid; Sonali Pechlivanis; N William Rayner; Laura J Scott; Steven Wiltshire; Loic Yengo; Leena Kinnunen; Elizabeth J Rossin; Soumya Raychaudhuri; Andrew D Johnson; Antigone S Dimas; Ruth J F Loos; Sailaja Vedantam; Han Chen; Jose C Florez; Caroline Fox; Ching-Ti Liu; Denis Rybin; David J Couper; Wen Hong L Kao; Man Li; Marilyn C Cornelis; Peter Kraft; Qi Sun; Rob M van Dam; Heather M Stringham; Peter S Chines; Krista Fischer; Pierre Fontanillas; Oddgeir L Holmen; Sarah E Hunt; Anne U Jackson; Augustine Kong; Robert Lawrence; Julia Meyer; John R B Perry; Carl G P Platou; Simon Potter; Emil Rehnberg; Neil Robertson; Suthesh Sivapalaratnam; Alena Stančáková; Kathleen Stirrups; Gudmar Thorleifsson; Emmi Tikkanen; Andrew R Wood; Peter Almgren; Mustafa Atalay; Rafn Benediktsson; Lori L Bonnycastle; Noël Burtt; Jason Carey; Guillaume Charpentier; Andrew T Crenshaw; Alex S F Doney; Mozhgan Dorkhan; Sarah Edkins; Valur Emilsson; Elodie Eury; Tom Forsen; Karl Gertow; Bruna Gigante; George B Grant; Christopher J Groves; Candace Guiducci; Christian Herder; Astradur B Hreidarsson; Jennie Hui; Alan James; Anna Jonsson; Wolfgang Rathmann; Norman Klopp; Jasmina Kravic; Kaarel Krjutškov; Cordelia Langford; Karin Leander; Eero Lindholm; Stéphane Lobbens; Satu Männistö; Ghazala Mirza; Thomas W Mühleisen; Bill Musk; Melissa Parkin; Loukianos Rallidis; Jouko Saramies; Bengt Sennblad; Sonia Shah; Gunnar Sigurðsson; Angela Silveira; Gerald Steinbach; Barbara Thorand; Joseph Trakalo; Fabrizio Veglia; Roman Wennauer; Wendy Winckler; Delilah Zabaneh; Harry Campbell; Cornelia van Duijn; Andre G Uitterlinden; Albert Hofman; Eric Sijbrands; Goncalo R Abecasis; Katharine R Owen; Eleftheria Zeggini; Mieke D Trip; Nita G Forouhi; Ann-Christine Syvänen; Johan G Eriksson; Leena Peltonen; Markus M Nöthen; Beverley Balkau; Colin N A Palmer; Valeriya Lyssenko; Tiinamaija Tuomi; Bo Isomaa; David J Hunter; Lu Qi; Alan R Shuldiner; Michael Roden; Ines Barroso; Tom Wilsgaard; John Beilby; Kees Hovingh; Jackie F Price; James F Wilson; Rainer Rauramaa; Timo A Lakka; Lars Lind; George Dedoussis; Inger Njølstad; Nancy L Pedersen; Kay-Tee Khaw; Nicholas J Wareham; Sirkka M Keinanen-Kiukaanniemi; Timo E Saaristo; Eeva Korpi-Hyövälti; Juha Saltevo; Markku Laakso; Johanna Kuusisto; Andres Metspalu; Francis S Collins; Karen L Mohlke; Richard N Bergman; Jaakko Tuomilehto; Bernhard O Boehm; Christian Gieger; Kristian Hveem; Stephane Cauchi; Philippe Froguel; Damiano Baldassarre; Elena Tremoli; Steve E Humphries; Danish Saleheen; John Danesh; Erik Ingelsson; Samuli Ripatti; Veikko Salomaa; Raimund Erbel; Karl-Heinz Jöckel; Susanne Moebus; Annette Peters; Thomas Illig; Ulf de Faire; Anders Hamsten; Andrew D Morris; Peter J Donnelly; Timothy M Frayling; Andrew T Hattersley; Eric Boerwinkle; Olle Melander; Sekar Kathiresan; Peter M Nilsson; Panos Deloukas; Unnur Thorsteinsdottir; Leif C Groop; Kari Stefansson; Frank Hu; James S Pankow; Josée Dupuis; James B Meigs; David Altshuler; Michael Boehnke; Mark I McCarthy
Journal:  Nat Genet       Date:  2012-08-12       Impact factor: 38.330
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