Literature DB >> 2447020

Monoclonal antibodies that recognize a specific surface antigen of Treponema denticola.

L G Simonson1, R F Rouse, S W Bockowski.   

Abstract

Spirochetes have been implicated as potential etiologic agents of periodontitis in humans. Murine monoclonal antibodies (MAbs) specific for a serogroup of Treponema denticola, an oral spirochete, were developed and characterized in this study. Antibodies secreted by clone IAA11 were judged to be the most useful, since they were able to detect 8 of 15 T. denticola strains. This MAb consisted of an immunoglobulin G3 heavy chain and a kappa light chain. MAb IAA11 was found to react with an epitope target located on the outer sheath of the cell wall. This MAb should be of diagnostic and scientific value in the study of T. denticola populations in human periodontitis.

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Year:  1988        PMID： 2447020      PMCID： PMC259234          DOI： 10.1128/iai.56.1.60-63.1988

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  9 in total

1.  Comparative study of six random oral spirochete isolates. Serological heterogeneity of Treponema denticola.

Authors:  S L Cheng; R Siboo; T C Quee; J L Johnson; W R Mayberry; E C Chan
Journal:  J Periodontal Res       Date:  1985-11       Impact factor: 4.419

2.  The routine isolation, growth, and maintenance of the intermediate-size anaerobic oral spirochetes from periodontal pockets.

Authors:  S L Cheng; E C Chan
Journal:  J Periodontal Res       Date:  1983-07       Impact factor: 4.419

3.  Positive correlation between the proportions of subgingival spirochetes and motile bacteria and susceptibility of human subjects to periodontal deterioration.

Authors:  M A Listgarten; S Levin
Journal:  J Clin Periodontol       Date:  1981-04       Impact factor: 8.728

4.  Immunological relationship among oral anaerobic spirochetes as detected by indirect microhemagglutination.

Authors:  E Jacob; T B Carter; R K Nauman
Journal:  J Clin Microbiol       Date:  1980-10       Impact factor: 5.948

5.  Relationship between the percentage of subgingival spirochetes and the severity of periodontal disease.

Authors:  G C Armitage; W R Dickinson; R S Jenderseck; S M Levine; D W Chambers
Journal:  J Periodontol       Date:  1982-09       Impact factor: 6.993

6.  Bacteriology of moderate (chronic) periodontitis in mature adult humans.

Authors:  W E Moore; L V Holdeman; E P Cato; R M Smibert; J A Burmeister; R R Ranney
Journal:  Infect Immun       Date:  1983-11       Impact factor: 3.441

7.  Bacteriology of severe periodontitis in young adult humans.

Authors:  W E Moore; L V Holdeman; R M Smibert; D E Hash; J A Burmeister; R R Ranney
Journal:  Infect Immun       Date:  1982-12       Impact factor: 3.441

8.  Common antigens of Treponema denticola: chemical, physical, and serological characterization.

Authors:  E Jacob; R K Nauman
Journal:  Infect Immun       Date:  1982-08       Impact factor: 3.441

9.  Production and characterization of monoclonal antibodies to Bacteroides gingivalis.

Authors:  L G Simonson; B R Merrell; R F Rouse; I L Shklair
Journal:  J Dent Res       Date:  1986-02       Impact factor: 6.116
  9 in total
  8 in total

1.  Quantitative relationship of Treponema denticola to severity of periodontal disease.

Authors:  L G Simonson; C H Goodman; J J Bial; H E Morton
Journal:  Infect Immun       Date:  1988-04       Impact factor: 3.441

2.  Quantitative immunoassay of Treponema denticola serovar C in adult periodontitis.

Authors:  L G Simonson; C H Goodman; H E Morton
Journal:  J Clin Microbiol       Date:  1990-07       Impact factor: 5.948

3.  Biochemical properties of the outer membrane of Treponema denticola.

Authors:  W W Yotis; V K Sharma; C Gopalsami; S Chegini; J McNulty; K Hoerman; J Keene; L G Simonson
Journal:  J Clin Microbiol       Date:  1991-07       Impact factor: 5.948

4.  Clustering of fibronectin adhesins toward Treponema denticola tips upon contact with immobilized fibronectin.

Authors:  J R Dawson; R P Ellen
Journal:  Infect Immun       Date:  1994-06       Impact factor: 3.441

5.  Sequence analysis, expression, and binding activity of recombinant major outer sheath protein (Msp) of Treponema denticola.

Authors:  J C Fenno; K H Müller; B C McBride
Journal:  J Bacteriol       Date:  1996-05       Impact factor: 3.490

6.  Pathogen-related spirochetes identified within gingival tissue from patients with acute necrotizing ulcerative gingivitis.

Authors:  G R Riviere; K S Weisz; L G Simonson; S A Lukehart
Journal:  Infect Immun       Date:  1991-08       Impact factor: 3.441

7.  A major antigen on the outer envelope of a human oral spirochete, Treponema denticola.

Authors:  T Umemoto; I Namikawa; H Suido; S Asai
Journal:  Infect Immun       Date:  1989-08       Impact factor: 3.441

8.  Multilocus sequence analysis of Treponema denticola strains of diverse origin.

Authors:  Sisu Mo; Meng You; Yvonne C F Su; Donnabella C Lacap-Bugler; Yong-biao Huo; Gavin J D Smith; W Keung Leung; Rory M Watt
Journal:  BMC Microbiol       Date:  2013-02-04       Impact factor: 3.605
  8 in total

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