Literature DB >> 24469060

The stem cell transcription factor ZFP57 induces IGF2 expression to promote anchorage-independent growth in cancer cells.

Y Tada1, Y Yamaguchi2, T Kinjo1, X Song1, T Akagi1, H Takamura2, T Ohta2, T Yokota1, H Koide1.   

Abstract

Several common biological properties between cancer cells and embryonic stem (ES) cells suggest the possibility that some genes expressed in ES cells might have important roles in cancer cell growth. The transcription factor ZFP57 is expressed in self-renewing ES cells and its expression level decreases during ES cell differentiation. This study showed that ZFP57 is involved in the anchorage-independent growth of human fibrosarcoma HT1080 cells in soft agar. ZFP57 overexpression enhanced, whereas knockdown suppressed, HT1080 tumor formation in nude mice. Furthermore, ZFP57 regulates the expression of insulin-like growth factor 2 (IGF2), which has a critical role in ZFP57-induced anchorage-independent growth. ZFP57 also promotes anchorage-independent growth in ES cells and immortal fibroblasts. Finally, immunohistochemical analysis revealed that ZFP57 is overexpressed in human cancer clinical specimens. Taken together, these results suggest that the ES-specific transcription factor ZFP57 is a novel oncogene.

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Year:  2014        PMID： 24469060     DOI： 10.1038/onc.2013.599

Source DB:  PubMed          Journal:  Oncogene        ISSN： 0950-9232            Impact factor:   9.867


  48 in total

1.  Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells.

Authors:  Shinji Masui; Yuhki Nakatake; Yayoi Toyooka; Daisuke Shimosato; Rika Yagi; Kazue Takahashi; Hitoshi Okochi; Akihiko Okuda; Ryo Matoba; Alexei A Sharov; Minoru S H Ko; Hitoshi Niwa
Journal:  Nat Cell Biol       Date:  2007-05-21       Impact factor: 28.824

2.  Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4.

Authors:  J Nichols; B Zevnik; K Anastassiadis; H Niwa; D Klewe-Nebenius; I Chambers; H Schöler; A Smith
Journal:  Cell       Date:  1998-10-30       Impact factor: 41.582

Review 3.  Embryo-derived stem cells: of mice and men.

Authors:  A G Smith
Journal:  Annu Rev Cell Dev Biol       Date:  2001       Impact factor: 13.827

4.  Identification of Zfp-57 as a downstream molecule of STAT3 and Oct-3/4 in embryonic stem cells.

Authors:  Tadayuki Akagi; Masayuki Usuda; Takahiko Matsuda; Minoru S H Ko; Hitoshi Niwa; Masahide Asano; Hiroshi Koide; Takashi Yokota
Journal:  Biochem Biophys Res Commun       Date:  2005-05-27       Impact factor: 3.575

5.  Evidence that Igf2 down-regulation in postnatal tissues and up-regulation in malignancies is driven by transcription factor E2f3.

Authors:  Julian C Lui; Jeffrey Baron
Journal:  Proc Natl Acad Sci U S A       Date:  2013-03-25       Impact factor: 11.205

6.  The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells.

Authors:  Kaoru Mitsui; Yoshimi Tokuzawa; Hiroaki Itoh; Kohichi Segawa; Mirei Murakami; Kazutoshi Takahashi; Masayoshi Maruyama; Mitsuyo Maeda; Shinya Yamanaka
Journal:  Cell       Date:  2003-05-30       Impact factor: 41.582

7.  Anchorage-independent cell growth signature identifies tumors with metastatic potential.

Authors:  S Mori; J T Chang; E R Andrechek; N Matsumura; T Baba; G Yao; J W Kim; M Gatza; S Murphy; J R Nevins
Journal:  Oncogene       Date:  2009-06-01       Impact factor: 9.867

8.  Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3.

Authors:  H Niwa; T Burdon; I Chambers; A Smith
Journal:  Genes Dev       Date:  1998-07-01       Impact factor: 11.361

9.  Functional evidence that the self-renewal gene NANOG regulates human tumor development.

Authors:  Collene R Jeter; Mark Badeaux; Grace Choy; Dhyan Chandra; Lubna Patrawala; Can Liu; Tammy Calhoun-Davis; Holm Zaehres; George Q Daley; Dean G Tang
Journal:  Stem Cells       Date:  2009-05       Impact factor: 6.277

10.  Genetic and epigenetic mutations affect the DNA binding capability of human ZFP57 in transient neonatal diabetes type 1.

Authors:  Ilaria Baglivo; Sabrina Esposito; Lucia De Cesare; Angela Sparago; Zahra Anvar; Vincenzo Riso; Marco Cammisa; Roberto Fattorusso; Giovanna Grimaldi; Andrea Riccio; Paolo V Pedone
Journal:  FEBS Lett       Date:  2013-03-13       Impact factor: 4.124
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  17 in total

1.  Informed genome-wide association analysis with family history as a secondary phenotype identifies novel loci of lung cancer.

Authors:  Julia G Poirier; Paul Brennan; James D McKay; Margaret R Spitz; Heike Bickeböller; Angela Risch; Geoffrey Liu; Loic Le Marchand; Shelley Tworoger; John McLaughlin; Albert Rosenberger; Joachim Heinrich; Irene Brüske; Thomas Muley; Brian E Henderson; Lynne R Wilkens; Xuchen Zong; Yafang Li; Ke Hao; Wim Timens; Yohan Bossé; Don D Sin; Ma'en Obeidat; Christopher I Amos; Rayjean J Hung
Journal:  Genet Epidemiol       Date:  2015-01-19       Impact factor: 2.135

2.  Carcinoma of the colon and rectum with deregulation of insulin-like growth factor 2 signaling: clinical and molecular implications.

Authors:  Djeda Belharazem; Julia Magdeburg; Ann-Kristin Berton; Li Beissbarth; Christian Sauer; Carsten Sticht; Alexander Marx; Ralf Hofheinz; Stefan Post; Peter Kienle; Philipp Ströbel
Journal:  J Gastroenterol       Date:  2016-03-17       Impact factor: 7.527

3.  IMP3 promotes stem-like properties in triple-negative breast cancer by regulating SLUG.

Authors:  S Samanta; H Sun; H L Goel; B Pursell; C Chang; A Khan; D L Greiner; S Cao; E Lim; L D Shultz; A M Mercurio
Journal:  Oncogene       Date:  2015-05-18       Impact factor: 9.867

4.  Genome-wide DNA methylation profiling identifies a folate-sensitive region of differential methylation upstream of ZFP57-imprinting regulator in humans.

Authors:  Manori Amarasekera; David Martino; Sarah Ashley; Hani Harb; Dörthe Kesper; Deborah Strickland; Richard Saffery; Susan L Prescott
Journal:  FASEB J       Date:  2014-06-02       Impact factor: 5.191

Review 5.  Insulin Receptor Isoforms in Physiology and Disease: An Updated View.

Authors:  Antonino Belfiore; Roberta Malaguarnera; Veronica Vella; Michael C Lawrence; Laura Sciacca; Francesco Frasca; Andrea Morrione; Riccardo Vigneri
Journal:  Endocr Rev       Date:  2017-10-01       Impact factor: 19.871

6.  Detection of epigenetic field defects using a weighted epigenetic distance-based method.

Authors:  Ya Wang; Min Qian; Peifeng Ruan; Andrew E Teschendorff; Shuang Wang
Journal:  Nucleic Acids Res       Date:  2019-01-10       Impact factor: 16.971

7.  A targetable GATA2-IGF2 axis confers aggressiveness in lethal prostate cancer.

Authors:  Samuel J Vidal; Veronica Rodriguez-Bravo; S Aidan Quinn; Ruth Rodriguez-Barrueco; Amaia Lujambio; Estrelania Williams; Xiaochen Sun; Janis de la Iglesia-Vicente; Albert Lee; Ben Readhead; Xintong Chen; Matthew Galsky; Berta Esteve; Daniel P Petrylak; Joel T Dudley; Raul Rabadan; Jose M Silva; Yujin Hoshida; Scott W Lowe; Carlos Cordon-Cardo; Josep Domingo-Domenech
Journal:  Cancer Cell       Date:  2015-02-09       Impact factor: 31.743

8.  ZNF37A promotes tumor metastasis through transcriptional control of THSD4/TGF-β axis in colorectal cancer.

Authors:  Jiayang Liu; Zhao Huang; Hai-Ning Chen; Siyuan Qin; Yan Chen; Jingwen Jiang; Zhe Zhang; Maochao Luo; Qin Ye; Na Xie; Zong-Guang Zhou; Yuquan Wei; Ke Xie; Canhua Huang
Journal:  Oncogene       Date:  2021-04-19       Impact factor: 9.867

9.  Essential role of insulin-like growth factor 2 in resistance to histone deacetylase inhibitors.

Authors:  S-C Lee; H-Y Min; H J Jung; K H Park; S Y Hyun; J Cho; J K Woo; S J Kwon; H-J Lee; F M Johnson; H-Y Lee
Journal:  Oncogene       Date:  2016-04-18       Impact factor: 9.867

Review 10.  DNA methylation as a potential mediator of environmental risks in the development of childhood acute lymphoblastic leukemia.

Authors:  Jessica A Timms; Caroline L Relton; Judith Rankin; Gordon Strathdee; Jill A McKay
Journal:  Epigenomics       Date:  2016-04-01       Impact factor: 4.778
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