Literature DB >> 2446611

Selective localization of vasoactive intestinal peptide and substance P in human eosinophils.

J Aliakbari1, S P Sreedharan, C W Turck, E J Goetzl.   

Abstract

Extracts of purified human eosinophils had a mean concentration of 72 fmol of immunoreactive vasoactive intestinal peptide and 21 fmol of substance P per 10(7) eosinophils, that were significantly higher than the content of immunoreactivity of the same neuropeptides in neutrophils, mononuclear leukocytes, and platelets. In contrast, the lower concentrations of calcitonin gene-related peptide and somatostatin were similar in extracts of all leukocytes. Chromatography of the peptides from eosinophils confirmed their identity with vasoactive intestinal peptide and substance P from neuroendocrine sources. Stores of some neuropeptides may endow eosinophils with unique roles in host defense and hypersensitivity reactions.

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Year:  1987        PMID： 2446611     DOI： 10.1016/s0006-291x(87)80293-0

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  31 in total

1.  Vasoactive intestinal peptide stimulates immunoglobulin production and growth of human B cells.

Authors:  C Ishioka; A Yoshida; H Kimata; H Mikawa
Journal:  Clin Exp Immunol       Date:  1992-03       Impact factor: 4.330

2.  Real-time reverse transcription-PCR quantitation of substance P receptor (NK-1R) mRNA.

Authors:  Jian-Ping Lai; Steven D Douglas; Yan-Jian Wang; Wen-Zhe Ho
Journal:  Clin Diagn Lab Immunol       Date:  2005-04

3.  Role of neurokinin-1 receptor in the initiation and maintenance of skin chronic inflammatory diseases.

Authors:  Sherrie J Divito; Adrian E Morelli; Adriana T Larregina
Journal:  Immunol Res       Date:  2011-08       Impact factor: 2.829

4.  Appearance of neuropeptides in ascitic fluid after peritoneal therapy with interleukin-2 and lymphokine-activated killer cells for intraabdominal malignancy.

Authors:  S A Schiogolev; E J Goetzl; W J Urba; D L Longo
Journal:  J Clin Immunol       Date:  1989-03       Impact factor: 8.317

Review 5.  Role of Substance P Neuropeptide in Inflammation, Wound Healing, and Tissue Homeostasis.

Authors:  Susmit Suvas
Journal:  J Immunol       Date:  2017-09-01       Impact factor: 5.422

6.  Vasoactive intestinal peptide signaling axis in human leukemia.

Authors:  Glenn Paul Dorsam; Keith Benton; Jarrett Failing; Sandeep Batra
Journal:  World J Biol Chem       Date:  2011-06-26

7.  Eosinophilic esophagitis: strictures, impactions, dysphagia.

Authors:  Seema Khan; Susan R Orenstein; Carlo Di Lorenzo; Samuel A Kocoshis; Philip E Putnam; Luther Sigurdsson; Theresa M Shalaby
Journal:  Dig Dis Sci       Date:  2003-01       Impact factor: 3.199

8.  Expression of mRNA for vasoactive intestinal peptide in normal human colon and during inflammation.

Authors:  A Schulte-Bockholt; J G Fink; D A Meier; M F Otterson; G L Telford; K Hopp; T R Koch
Journal:  Mol Cell Biochem       Date:  1995-01-12       Impact factor: 3.396

9.  Endogenous substance P mediates cold water stress-induced increase in interleukin-6 secretion from peritoneal macrophages.

Authors:  G F Zhu; C Chancellor-Freeland; A S Berman; R Kage; S E Leeman; D I Beller; P H Black
Journal:  J Neurosci       Date:  1996-06-01       Impact factor: 6.167

10.  Induction of colitis causes inflammatory responses in fat depots: evidence for substance P pathways in human mesenteric preadipocytes.

Authors:  Iordanes Karagiannides; Efi Kokkotou; Morris Tansky; Tamara Tchkonia; Nino Giorgadze; Michael O'Brien; Susan E Leeman; James L Kirkland; Charalabos Pothoulakis
Journal:  Proc Natl Acad Sci U S A       Date:  2006-03-20       Impact factor: 11.205
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