Okihiro Nishi1, Yutaro Nishi2, Shiao Chang2, Kayo Nishi2. 1. From the Jinshikai Medical Foundation (O. Nishi, Y. Nishi, K. Nishi), Nishi Eye Hospital, Osaka, Japan; Calhoun Vision Institute (Chang), Pasadena, California, USA. Electronic address: okihiro@nishi-ganka.or.jp. 2. From the Jinshikai Medical Foundation (O. Nishi, Y. Nishi, K. Nishi), Nishi Eye Hospital, Osaka, Japan; Calhoun Vision Institute (Chang), Pasadena, California, USA.
Abstract
PURPOSE: To evaluate whether a new capsular bag-refilling procedure provides some accommodation in monkey eyes and to assess the difference in accommodation with different volumes of capsular bag refilling. SETTING: Jinshikai Medical Foundation, Nishi Eye Hospital, Osaka, Japan. DESIGN: Experimental study. METHODS: A central 3.0 to 4.0 mm continuous curvilinear capsulorhexis was created, after which phacoemulsification was performed in the usual manner. A new accommodating-membrane intraocular lens (IOL) for sealing the capsular opening was implanted in the capsular bag. Silicone polymers were injected beneath the IOL into the capsular bag through the delivery hole. In 3 study groups, each with 6 monkey eyes, the lens capsule was refilled with 0.080 mL of silicone polymers, corresponding to a 65% bag volume; 0.100 mL, corresponding to an 80% bag volume; or 0.125 mL, corresponding to a 100% bag volume. To calculate the accommodation amplitudes achieved, automated refractometry was performed before and 1 hour after topical pilocarpine 4.0% application preoperatively and 4 weeks postoperatively. RESULTS: The refilling technique was successful without polymer leakage in all monkeys. Four weeks after surgery, the mean accommodation amplitudes were 2.56 diopters (D) ± 0.74 (SD), 2.42 ± 1.00 D, and 2.71 ± 0.63 D, respectively, in the 3 study groups. CONCLUSIONS: The technique provided some accommodation in young monkey eyes. Leakage of the injectable silicone polymers and anterior capsule opacification in the visual axis were avoided. The results suggest that the capsular bag-refilling procedure warrants further study for possible clinical application. FINANCIAL DISCLOSURE: All authors have a proprietary interest in the accommodating membrane IOL mentioned in the article.
PURPOSE: To evaluate whether a new capsular bag-refilling procedure provides some accommodation in monkey eyes and to assess the difference in accommodation with different volumes of capsular bag refilling. SETTING: Jinshikai Medical Foundation, Nishi Eye Hospital, Osaka, Japan. DESIGN: Experimental study. METHODS: A central 3.0 to 4.0 mm continuous curvilinear capsulorhexis was created, after which phacoemulsification was performed in the usual manner. A new accommodating-membrane intraocular lens (IOL) for sealing the capsular opening was implanted in the capsular bag. Silicone polymers were injected beneath the IOL into the capsular bag through the delivery hole. In 3 study groups, each with 6 monkey eyes, the lens capsule was refilled with 0.080 mL of silicone polymers, corresponding to a 65% bag volume; 0.100 mL, corresponding to an 80% bag volume; or 0.125 mL, corresponding to a 100% bag volume. To calculate the accommodation amplitudes achieved, automated refractometry was performed before and 1 hour after topical pilocarpine 4.0% application preoperatively and 4 weeks postoperatively. RESULTS: The refilling technique was successful without polymer leakage in all monkeys. Four weeks after surgery, the mean accommodation amplitudes were 2.56 diopters (D) ± 0.74 (SD), 2.42 ± 1.00 D, and 2.71 ± 0.63 D, respectively, in the 3 study groups. CONCLUSIONS: The technique provided some accommodation in young monkey eyes. Leakage of the injectable silicone polymers and anterior capsule opacification in the visual axis were avoided. The results suggest that the capsular bag-refilling procedure warrants further study for possible clinical application. FINANCIAL DISCLOSURE: All authors have a proprietary interest in the accommodating membrane IOL mentioned in the article.
Authors: Steven A Koopmans; Thom Terwee; Adrian Glasser; Mark Wendt; Abhiram S Vilupuru; Abhiram S Vilipuru; Theo G van Kooten; Sverker Norrby; Henk J Haitjema; Aart C Kooijman Journal: Invest Ophthalmol Vis Sci Date: 2006-07 Impact factor: 4.799
Authors: E Haefliger; J M Parel; F Fantes; E W Norton; D R Anderson; R K Forster; E Hernandez; W J Feuer Journal: Ophthalmology Date: 1987-05 Impact factor: 12.079