| Literature DB >> 2445909 |
K Murray1, S A Bruce, P Wingfield, P van Eerd, A de Reus, H Schellekens.
Abstract
Preparations of hepatitis B virus (HBV) core antigen (HBcAg) synthesised in Escherichia coli have been shown previously to confer partial immunity against infection by the virus [Murray, Bruce, Hinnen, Wingfield, van Eerd, de Reus, and Schellekens: EMBO Journal 3:645-650, 1984]. In a further experiment reported here, immunisation of chimpanzees with a similar preparation of HBcAg that had been treated with sodium dodecyl sulphate in order to expose e antigen epitopes was found to protect one animal completely and another quite substantially upon challenge with the virus. The results are used to support the argument for trials in humans of a vaccine against HBV based upon or containing HBcAg and its e antigen derivative, and in discussion of a more general role for internal antigens in generating immunity against viral infection.Entities:
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Year: 1987 PMID： 2445909 DOI： 10.1002/jmv.1890230202
Source DB: PubMed Journal: J Med Virol ISSN： 0146-6615 Impact factor: 2.327