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Literature DB >> 24457012

Regulation of the latent-lytic switch in Epstein-Barr virus.

Abstract

Epstein-Barr virus (EBV) infection contributes to the development of several different types of human malignancy, including Burkitt lymphoma, Hodgkin lymphoma, and nasopharyngeal carcinoma. As a herpesvirus, EBV can establish latent or lytic infection in cells. EBV-positive tumors are composed almost exclusively of cells with latent EBV infection. Strategies for inducing the lytic form of EBV infection in tumor cells are being investigated as a potential therapy for EBV-positive tumors. In this article, we review how cellular and viral proteins regulate the latent-lytic EBV switch in infected B cells and epithelial cells, and discuss how harnessing lytic viral reactivation might be used therapeutically.

Entities: CellLine Chemical Disease Gene Species

Keywords: Ataxia-telangiectasia mutated (ATM); Genome methylation; Hypoxia; Lytic induction therapy; TGF-β

Mesh：

Year: 2014 PMID： 24457012 PMCID： PMC4048781 DOI： 10.1016/j.semcancer.2014.01.002

Source DB: PubMed Journal: Semin Cancer Biol ISSN： 1044-579X Impact factor: 15.707

97 in total

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Journal: Nat Genet Date: 2004-09-12 Impact factor: 38.330

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Journal: J Virol Date: 2004-05 Impact factor: 5.103

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Journal: Oncogene Date: 2003-08-11 Impact factor: 9.867

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Journal: EMBO J Date: 2003-05-15 Impact factor: 11.598

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Authors: Wen-hai Feng; Gregory Hong; Henri-Jacques Delecluse; Shannon C Kenney
Journal: J Virol Date: 2004-02 Impact factor: 5.103

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Journal: Proc Natl Acad Sci U S A Date: 1996-08-20 Impact factor: 11.205

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Authors: S Zalani; E Holley-Guthrie; S Kenney
Journal: J Virol Date: 1995-06 Impact factor: 5.103

120 in total

Review 1. EBV Persistence--Introducing the Virus.

Authors: David A Thorley-Lawson
Journal: Curr Top Microbiol Immunol Date: 2015 Impact factor: 4.291

2. BZLF1 transcript variants in Epstein-Barr virus-positive epithelial cell lines.

Authors: Jason Needham; Amy L Adamson
Journal: Virus Genes Date: 2019-09-24 Impact factor: 2.332

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Authors: Lindsey M Hutt-Fletcher
Journal: J Virol Date: 2016-12-16 Impact factor: 5.103

4. A Conserved Gammaherpesvirus Cyclin Specifically Bypasses Host p18(INK4c) To Promote Reactivation from Latency.

Authors: Lisa M Williams; Brian F Niemeyer; David S Franklin; Eric T Clambey; Linda F van Dyk
Journal: J Virol Date: 2015-08-19 Impact factor: 5.103

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Authors: Sheila Mansouri; Qun Pan; Benjamin J Blencowe; Julie M Claycomb; Lori Frappier
Journal: J Virol Date: 2014-07-16 Impact factor: 5.103

6. Plasmablastic transformation of a pre-existing plasmacytoma: a possible role for reactivation of Epstein Barr virus infection.

Authors: Maria R Ambrosio; Giulia De Falco; Alessandro Gozzetti; Bruno J Rocca; Teresa Amato; Vasileios Mourmouras; Sara Gazaneo; Lucia Mundo; Veronica Candi; Pier P Piccaluga; Maria G Cusi; Lorenzo Leoncini; Stefano Lazzi
Journal: Haematologica Date: 2014-09-05 Impact factor: 9.941

Review 7. Detecting and interpreting DNA methylation marks.

Authors: Ren Ren; John R Horton; Xing Zhang; Robert M Blumenthal; Xiaodong Cheng
Journal: Curr Opin Struct Biol Date: 2018-07-19 Impact factor: 6.809

8. (-)-Epigallocatechin-3-gallate inhibition of Epstein-Barr virus spontaneous lytic infection involves downregulation of latent membrane protein 1.

Authors: Sufang Liu; Hongde Li; Min Tang; Ya Cao
Journal: Exp Ther Med Date: 2017-11-13 Impact factor: 2.447

Review 9. The role of Epstein-Barr virus infection in the pathogenesis of nasopharyngeal carcinoma.

Authors: Chi Man Tsang; Sai Wah Tsao
Journal: Virol Sin Date: 2015-04-21 Impact factor: 4.327

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Authors: Adityarup Chakravorty; Bill Sugden; Eric C Johannsen
Journal: J Virol Date: 2019-04-03 Impact factor: 5.103