Literature DB >> 15361873

The EBV lytic switch protein, Z, preferentially binds to and activates the methylated viral genome.

Prasanna M Bhende1, William T Seaman, Henri-Jacques Delecluse, Shannon C Kenney.   

Abstract

DNA methylation promotes gene silencing, yet the Epstein-Barr virus immediate-early protein, BZLF1 (Z), converts the virus from the latent to the lytic form of infection even when the viral genome is highly methylated. Here we show that methylation of CpG motifs in Z-responsive elements of the viral BRLF1 immediate-early promoter enhances Z binding to, and activation of, this promoter. Demethylation of the viral genome impairs Z activation of lytic viral genes. Z is the first transcription factor that preferentially binds to, and activates, a methylated promoter. These results identify an unexpected mechanism by which Epstein-Barr virus circumvents the inhibitory effects of viral genome methylation.

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Year:  2004        PMID： 15361873     DOI： 10.1038/ng1424

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  106 in total

1.  Epstein-Barr virus LF2 protein regulates viral replication by altering Rta subcellular localization.

Authors:  Andreas M F Heilmann; Michael A Calderwood; Eric Johannsen
Journal:  J Virol       Date:  2010-07-14       Impact factor: 5.103

2.  Evidence for DNA hairpin recognition by Zta at the Epstein-Barr virus origin of lytic replication.

Authors:  Andrew J Rennekamp; Pu Wang; Paul M Lieberman
Journal:  J Virol       Date:  2010-05-05       Impact factor: 5.103

3.  Repression of CIITA by the Epstein-Barr virus transcription factor Zta is independent of its dimerization and DNA binding.

Authors:  Nicolae Balan; Kay Osborn; Alison J Sinclair
Journal:  J Gen Virol       Date:  2015-12-11       Impact factor: 3.891

4.  Multivalent sequence recognition by Epstein-Barr virus Zta requires cysteine 171 and an extension of the canonical B-ZIP domain.

Authors:  Pu Wang; Latasha Day; Paul M Lieberman
Journal:  J Virol       Date:  2006-09-13       Impact factor: 5.103

5.  Amino acids in the basic domain of Epstein-Barr virus ZEBRA protein play distinct roles in DNA binding, activation of early lytic gene expression, and promotion of viral DNA replication.

Authors:  Lee Heston; Ayman El-Guindy; Jill Countryman; Charles Dela Cruz; Henri-Jacques Delecluse; George Miller
Journal:  J Virol       Date:  2006-09       Impact factor: 5.103

6.  Mutation of a single amino acid residue in the basic region of the Epstein-Barr virus (EBV) lytic cycle switch protein Zta (BZLF1) prevents reactivation of EBV from latency.

Authors:  Celine Schelcher; Sarah Valencia; Henri-Jacques Delecluse; Matthew Hicks; Alison J Sinclair
Journal:  J Virol       Date:  2005-11       Impact factor: 5.103

7.  ORF18 is a transfactor that is essential for late gene transcription of a gammaherpesvirus.

Authors:  Vaithilingaraja Arumugaswami; Ting-Ting Wu; DeeAnn Martinez-Guzman; Qingmei Jia; Hongyu Deng; Nichole Reyes; Ren Sun
Journal:  J Virol       Date:  2006-10       Impact factor: 5.103

Review 8.  Detecting and interpreting DNA methylation marks.

Authors:  Ren Ren; John R Horton; Xing Zhang; Robert M Blumenthal; Xiaodong Cheng
Journal:  Curr Opin Struct Biol       Date:  2018-07-19       Impact factor: 6.809

Review 9.  An Epigenetic Journey: Epstein-Barr Virus Transcribes Chromatinized and Subsequently Unchromatinized Templates during Its Lytic Cycle.

Authors:  Adityarup Chakravorty; Bill Sugden; Eric C Johannsen
Journal:  J Virol       Date:  2019-04-03       Impact factor: 5.103

Review 10.  Epigenetic regulation of EBV persistence and oncogenesis.

Authors:  Italo Tempera; Paul M Lieberman
Journal:  Semin Cancer Biol       Date:  2014-01-24       Impact factor: 15.707
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