Seung-Hwan Lee1, Sunkyung Yoon2, Jeong-In Kim3, Seung-Hyun Jin4, Chun Kee Chung4. 1. Department of Psychiatry, Inje University, Ilsan-Paik Hospital, 2240 Daehwa-dong, Ilsanseo-gu, Goyang, Republic of Korea; Clinical Emotion and Cognition Research Laboratory, 2240 Daehwa-dong, Ilsanseo-gu, Goyang, Republic of Korea. Electronic address: lshpss@paik.ac.kr. 2. Clinical Emotion and Cognition Research Laboratory, 2240 Daehwa-dong, Ilsanseo-gu, Goyang, Republic of Korea; Department of Psychology, Sogang University, 35 Baekbeom-ro, Mapo-gu, Seoul, Republic of Korea. 3. Clinical Emotion and Cognition Research Laboratory, 2240 Daehwa-dong, Ilsanseo-gu, Goyang, Republic of Korea. 4. Department of Neurosurgery, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, Republic of Korea.
Abstract
OBJECTIVES: Post-traumatic stress disorder (PTSD) is thought to be a brain network disorder. This study aimed to examine the resting-state functional connectivity (FC) in patients with PTSD. METHODS: Thirty-three PTSD patients and 30 age- and gender-matched healthy controls were recruited. Symptom severity of the PTSD patients was assessed, and 62-channel EEG was measured. EEGs were recorded during the resting state, with the eyes closed. Three nodal network measures to assess nodal centrality [nodal degree (Dnodal; connection strength), nodal efficiency (Enodal; communication efficiency), and betweenness centrality (BC; connection centrality)] were calculated in the delta, theta, alpha, beta, and gamma bands. RESULTS: Dnodal and Enodal of the beta and gamma bands were decreased in PTSD patients compared to healthy controls. These decreased nodal centrality values were observed primarily at the frontocentral electrodes. In addition, Dnodal of the beta and gamma bands was significantly correlated with depressive symptoms and increased arousal symptoms, respectively. Enodal of the beta and gamma bands was significantly correlated with re-experience, increased arousal, and the severity and frequency of general PTSD symptoms. CONCLUSION: Compared to controls, patients with PTSD were found to have decreased resting-state FC, and these FC measures were significantly correlated with PTSD symptom severity. Our results suggest that resting-state FC could be a useful biomarker for PTSD.
OBJECTIVES: Post-traumatic stress disorder (PTSD) is thought to be a brain network disorder. This study aimed to examine the resting-state functional connectivity (FC) in patients with PTSD. METHODS: Thirty-three PTSDpatients and 30 age- and gender-matched healthy controls were recruited. Symptom severity of the PTSDpatients was assessed, and 62-channel EEG was measured. EEGs were recorded during the resting state, with the eyes closed. Three nodal network measures to assess nodal centrality [nodal degree (Dnodal; connection strength), nodal efficiency (Enodal; communication efficiency), and betweenness centrality (BC; connection centrality)] were calculated in the delta, theta, alpha, beta, and gamma bands. RESULTS: Dnodal and Enodal of the beta and gamma bands were decreased in PTSDpatients compared to healthy controls. These decreased nodal centrality values were observed primarily at the frontocentral electrodes. In addition, Dnodal of the beta and gamma bands was significantly correlated with depressive symptoms and increased arousal symptoms, respectively. Enodal of the beta and gamma bands was significantly correlated with re-experience, increased arousal, and the severity and frequency of general PTSD symptoms. CONCLUSION: Compared to controls, patients with PTSD were found to have decreased resting-state FC, and these FC measures were significantly correlated with PTSD symptom severity. Our results suggest that resting-state FC could be a useful biomarker for PTSD.
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