| Literature DB >> 24447636 |
Shuangmei Liu1, Chunping Zhang1, Qingming Shi2, Guilin Li1, Miaomiao Song1, Yun Gao1, Changshui Xu1, Hong Xu1, Bo Fan1, Shicheng Yu1, Chaoran Zheng1, Qicheng Zhu1, Bing Wu1, Lichao Peng1, Huangui Xiong1, Qin Wu1, Shangdong Liang3.
Abstract
P2X₃ receptors in stellate ganglia (SG) and cervical dorsal root ganglia (DRG) neurons are involved in sympathoexcitatory reflex induced by myocardial ischemic damage. Puerarin, a major active ingredient extracted from the traditional Chinese plant medicine Ge-gen, has been widely used in treatment of myocardial and cerebral ischemia. The present study is aimed to observe the effects of puerarin on the signaling transmission mediated by P2X₃ receptor in SG and DRG after myocardial ischemic damage. Our results showed that systolic blood pressure and heart rate increased, and the expression levels of P2X₃ mRNA and protein in SG and DRG were up-regulated after myocardial ischemic damage. Puerarin reduced systolic blood pressure and heart rate, relieved pain and decreased up-regulated expression of P2X₃ mRNA and protein in SG and DRG after myocardial ischemia. Puerarin inhibited the up-regulated ATP-activated currents in DRG neurons after myocardial ischemia. Thus, puerarin can relieve myocardial ischemic damage through blocking the P2X₃ signaling transmission and then depressed the aggravated sympathoexcitatory reflex.Entities:
Keywords: Dorsal root ganglia; Myocardial ischemia; P2X(3) receptor; Puerarin; Stellate ganglia
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Year: 2014 PMID： 24447636 DOI： 10.1016/j.brainresbull.2014.01.001
Source DB: PubMed Journal: Brain Res Bull ISSN： 0361-9230 Impact factor: 4.077