Literature DB >> 24440906

Antiplasmodial and cytotoxic dibenzofurans from Preussia sp. harboured in Enantia chlorantha Oliv.

Ferdinand Mouafo Talontsi1, Marc Lamshöft1, Clovis Douanla-Meli2, Simeon Fogue Kouam3, Michael Spiteller4.   

Abstract

Two unusual dibenzofurans, preussiafurans A-B (1-2), together with six known compounds have been isolated from the fungus Preussia sp. occurring in Enantia chlorantha Oliv. The structures were established on the basis of 1D and 2D NMR spectroscopy and MS analysis. Compounds 1-4 showed antiplasmodial activity against erythrocytic stages of chloroquine-resistant Plasmodium falciparum (NF54) and moderate cytotoxicity on L6 cell lines with IC50 values of 8.67 and 14.8 μM, respectively.
Copyright © 2014 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Antiplasmodial activity; Cytotoxicity; Dibenzofurans; Enanthia chloranta Oliv; Endophyte; Preussia sp.

Mesh：

Substances：

Year:  2014        PMID： 24440906     DOI： 10.1016/j.fitote.2014.01.003

Source DB:  PubMed          Journal:  Fitoterapia        ISSN： 0367-326X            Impact factor:   2.882


  7 in total

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