Literature DB >> 24440402

Polyethylene glycol-phosphatidylethanolamine (PEG-PE)/vitamin E micelles for co-delivery of paclitaxel and curcumin to overcome multi-drug resistance in ovarian cancer.

Abraham H Abouzeid1, Niravkumar R Patel1, Vladimir P Torchilin2.   

Abstract

The therapeutic potential of mixed micelles, made of PEG-PE and vitamin E co-loaded with curcumin and paclitaxel, was investigated against SK-OV-3 human ovarian adenocarcinoma along with its multi-drug resistant version SK-OV-3-paclitaxel-resistant (TR) cells in vitro and in vivo. The addition of curcumin at various concentrations did not significantly enhance the cytotoxicity of paclitaxel against SK-OV-3 in vitro. However, a clear synergistic effect was observed with the combination treatment against SK-OV-3TR in vitro. In vivo, this combination treatment produced a three-fold tumor inhibition with each of these cell lines. Our results indicate that such co-loaded mixed micelles could have significant clinical advantages for the treatment of resistant ovarian cancer.
Copyright © 2014 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Combination therapy; Curcumin; Mixed micelles; Multi-drug resistance; Nuclear factor-kappa B (NF-κB); Ovarian cancer

Mesh：

Substances：

Year:  2014        PMID： 24440402      PMCID： PMC3980878          DOI： 10.1016/j.ijpharm.2014.01.009

Source DB:  PubMed          Journal:  Int J Pharm        ISSN： 0378-5173            Impact factor:   5.875


  21 in total

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