Literature DB >> 24436778

Highly Potent, Chemically Stable Quorum Sensing Agonists for Vibrio Cholerae.

Lark J Perez1, Theodora K Karagounis1, Amanda Hurley2, Bonnie L Bassler3, Martin F Semmelhack1.   

Abstract

In the Vibrio cholerae pathogen, initiation of bacterial quorum sensing pathways serves to suppress virulence. We describe herein a potent and chemically stable small molecule agonist of V. cholerae quorum sensing, which was identified through rational drug design based on the native quorum sensing signal. This novel agonist may serve as a useful lead compound for the control of virulence in V. cholerae.

Entities:  

Year:  2014        PMID： 24436778      PMCID： PMC3890260          DOI： 10.1039/C3SC52572D

Source DB:  PubMed          Journal:  Chem Sci        ISSN： 2041-6520            Impact factor:   9.825


  39 in total

1.  Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors.

Authors:  Morten Hentzer; Hong Wu; Jens Bo Andersen; Kathrin Riedel; Thomas B Rasmussen; Niels Bagge; Naresh Kumar; Mark A Schembri; Zhijun Song; Peter Kristoffersen; Mike Manefield; John W Costerton; Søren Molin; Leo Eberl; Peter Steinberg; Staffan Kjelleberg; Niels Høiby; Michael Givskov
Journal:  EMBO J       Date:  2003-08-01       Impact factor: 11.598

Review 2.  Quorum sensing: cell-to-cell communication in bacteria.

Authors:  Christopher M Waters; Bonnie L Bassler
Journal:  Annu Rev Cell Dev Biol       Date:  2005       Impact factor: 13.827

Review 3.  Anti-virulence strategies to combat bacteria-mediated disease.

Authors:  David A Rasko; Vanessa Sperandio
Journal:  Nat Rev Drug Discov       Date:  2010-01-18       Impact factor: 84.694

Review 4.  Census and consensus in bacterial ecosystems: the LuxR-LuxI family of quorum-sensing transcriptional regulators.

Authors:  C Fuqua; S C Winans; E P Greenberg
Journal:  Annu Rev Microbiol       Date:  1996       Impact factor: 15.500

5.  Quorum sensing and silencing in Vibrio parahaemolyticus.

Authors:  Cindy J Gode-Potratz; Linda L McCarter
Journal:  J Bacteriol       Date:  2011-06-24       Impact factor: 3.490

6.  LuxO controls extracellular protease, haemolytic activities and siderophore production in fish pathogen Vibrio alginolyticus.

Authors:  Q Wang; Q Liu; Y Ma; H Rui; Y Zhang
Journal:  J Appl Microbiol       Date:  2007-11       Impact factor: 3.772

Review 7.  Do enthalpy and entropy distinguish first in class from best in class?

Authors:  Ernesto Freire
Journal:  Drug Discov Today       Date:  2008-08-26       Impact factor: 7.851

8.  A quorum-sensing antagonist targets both membrane-bound and cytoplasmic receptors and controls bacterial pathogenicity.

Authors:  Lee R Swem; Danielle L Swem; Colleen T O'Loughlin; Raleene Gatmaitan; Bixiao Zhao; Scott M Ulrich; Bonnie L Bassler
Journal:  Mol Cell       Date:  2009-07-31       Impact factor: 17.970

9.  Broad spectrum pro-quorum-sensing molecules as inhibitors of virulence in vibrios.

Authors:  Wai-Leung Ng; Lark Perez; Jianping Cong; Martin F Semmelhack; Bonnie L Bassler
Journal:  PLoS Pathog       Date:  2012-06-28       Impact factor: 6.823

10.  The Vibrio cholerae quorum-sensing autoinducer CAI-1: analysis of the biosynthetic enzyme CqsA.

Authors:  Robert C Kelly; Megan E Bolitho; Douglas A Higgins; Wenyun Lu; Wai-Leung Ng; Philip D Jeffrey; Joshua D Rabinowitz; Martin F Semmelhack; Frederick M Hughson; Bonnie L Bassler
Journal:  Nat Chem Biol       Date:  2009-10-18       Impact factor: 15.040
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  9 in total

1.  A Periplasmic Polymer Curves Vibrio cholerae and Promotes Pathogenesis.

Authors:  Thomas M Bartlett; Benjamin P Bratton; Amit Duvshani; Amanda Miguel; Ying Sheng; Nicholas R Martin; Jeffrey P Nguyen; Alexandre Persat; Samantha M Desmarais; Michael S VanNieuwenhze; Kerwyn Casey Huang; Jun Zhu; Joshua W Shaevitz; Zemer Gitai
Journal:  Cell       Date:  2017-01-12       Impact factor: 41.582

Review 2.  Living in the matrix: assembly and control of Vibrio cholerae biofilms.

Authors:  Jennifer K Teschler; David Zamorano-Sánchez; Andrew S Utada; Christopher J A Warner; Gerard C L Wong; Roger G Linington; Fitnat H Yildiz
Journal:  Nat Rev Microbiol       Date:  2015-05       Impact factor: 60.633

3.  Modulating Vibrio cholerae quorum-sensing-controlled communication using autoinducer-loaded nanoparticles.

Authors:  Hoang D Lu; Alina C Spiegel; Amanda Hurley; Lark J Perez; Katharina Maisel; Laura M Ensign; Justin Hanes; Bonnie L Bassler; Martin F Semmelhack; Robert K Prud'homme
Journal:  Nano Lett       Date:  2015-03-03       Impact factor: 11.189

Review 4.  Genetic control of bacterial biofilms.

Authors:  Krystyna I Wolska; Anna M Grudniak; Zofia Rudnicka; Katarzyna Markowska
Journal:  J Appl Genet       Date:  2015-08-21       Impact factor: 3.240

5.  Asymmetric regulation of quorum-sensing receptors drives autoinducer-specific gene expression programs in Vibrio cholerae.

Authors:  Amanda Hurley; Bonnie L Bassler
Journal:  PLoS Genet       Date:  2017-05-26       Impact factor: 5.917

Review 6.  Progress in Alternative Strategies to Combat Antimicrobial Resistance: Focus on Antibiotics.

Authors:  Jayaseelan Murugaiyan; P Anand Kumar; G Srinivasa Rao; Katia Iskandar; Stephen Hawser; John P Hays; Yara Mohsen; Saranya Adukkadukkam; Wireko Andrew Awuah; Ruiz Alvarez Maria Jose; Nanono Sylvia; Esther Patience Nansubuga; Bruno Tilocca; Paola Roncada; Natalia Roson-Calero; Javier Moreno-Morales; Rohul Amin; Ballamoole Krishna Kumar; Abishek Kumar; Abdul-Rahman Toufik; Thaint Nadi Zaw; Oluwatosin O Akinwotu; Maneesh Paul Satyaseela; Maarten B M van Dongen
Journal:  Antibiotics (Basel)       Date:  2022-02-04

7.  One-pot sequential multicomponent reaction between in situ generated aldimines and succinaldehyde: facile synthesis of substituted pyrrole-3-carbaldehydes and applications towards medicinally important fused heterocycles.

Authors:  Anoop Singh; Nisar A Mir; Sachin Choudhary; Deepika Singh; Preetika Sharma; Rajni Kant; Indresh Kumar
Journal:  RSC Adv       Date:  2018-04-24       Impact factor: 4.036

Review 8.  Quorum quenching agents: resources for antivirulence therapy.

Authors:  Kaihao Tang; Xiao-Hua Zhang
Journal:  Mar Drugs       Date:  2014-05-30       Impact factor: 5.118

Review 9.  The arsenal of pathogens and antivirulence therapeutic strategies for disarming them.

Authors:  John R Brannon; Maria Hadjifrangiskou
Journal:  Drug Des Devel Ther       Date:  2016-05-27       Impact factor: 4.162
  9 in total

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