Literature DB >> 2443636

The presence of mucosa reduces the contractile response of the guinea-pig urinary bladder to substance P.

C A Maggi1, P Santicioli, M Parlani, M Astolfi, R Patacchini, A Meli.   

Abstract

The contractile response to substance P in-vitro is greater in strips of guinea-pig bladder freed of mucosa than in normal strips, while the response to field stimulation, histamine or KCl is unaffected by the presence of mucosa. Substance P has no inhibitory effect on histamine-induced contractions of the guinea-pig bladder. These findings support the possibility that the presence of mucosa may reduce accessibility of substance P to the muscle layer.

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Year:  1987        PMID： 2443636     DOI： 10.1111/j.2042-7158.1987.tb03447.x

Source DB:  PubMed          Journal:  J Pharm Pharmacol        ISSN： 0022-3573            Impact factor:   3.765


  16 in total

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2.  Expression and functional role of beta-adrenoceptors in the human urinary bladder urothelium.

Authors:  Atsushi Otsuka; Hitoshi Shinbo; Rikiya Matsumoto; Yutaka Kurita; Seiichiro Ozono
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2008-03-01       Impact factor: 3.000

Review 3.  Modulation of lower urinary tract smooth muscle contraction and relaxation by the urothelium.

Authors:  Donna Sellers; Russ Chess-Williams; Martin C Michel
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2018-05-28       Impact factor: 3.000

4.  Multiple mechanisms in the motor responses of the guinea-pig isolated urinary bladder to bradykinin.

Authors:  C A Maggi; R Patacchini; P Santicioli; P Geppetti; R Cecconi; S Giuliani; A Meli
Journal:  Br J Pharmacol       Date:  1989-10       Impact factor: 8.739

Review 5.  The Urothelium: Life in a Liquid Environment.

Authors:  Marianela G Dalghi; Nicolas Montalbetti; Marcelo D Carattino; Gerard Apodaca
Journal:  Physiol Rev       Date:  2020-03-19       Impact factor: 37.312

6.  Metabolic studies on rabbit bladder smooth muscle and mucosa.

Authors:  J A Hypolite; P A Longhurst; C Gong; J Briscoe; A J Wein; R M Levin
Journal:  Mol Cell Biochem       Date:  1993-08-11       Impact factor: 3.396

7.  Effect of rilmakalim on detrusor contraction in the presence and absence of urothelium.

Authors:  Melinda Wuest; Susann Kaden; Oliver W Hakenberg; Manfred P Wirth; Ursula Ravens
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2005-11-11       Impact factor: 3.000

8.  Protease-activated receptor-2-mediated contraction in the rat urinary bladder: the role of urinary bladder mucosa.

Authors:  Tsutomu Nakahara; Yuko Kubota; Akiko Mitani; Takeshi Maruko; Kenji Sakamoto; Kunio Ishii
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2003-01-24       Impact factor: 3.000

9.  Removal of urothelium affects bladder contractility and release of ATP but not release of NO in rat urinary bladder.

Authors:  Alvaro Munoz; David A Gangitano; Christopher P Smith; Timothy B Boone; George T Somogyi
Journal:  BMC Urol       Date:  2010-05-24       Impact factor: 2.264

10.  Possible involvement of Ca2+-independent phospholipase A2 in protease-activated receptor-2-mediated contraction of rat urinary bladder.

Authors:  Yuko Kubota; Tsutomu Nakahara; Akiko Mitani; Takeshi Maruko; Maki Saito; Kenji Sakamoto; Kunio Ishii
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2003-05-15       Impact factor: 3.000
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