Literature DB >> 12595964

Protease-activated receptor-2-mediated contraction in the rat urinary bladder: the role of urinary bladder mucosa.

Tsutomu Nakahara1, Yuko Kubota, Akiko Mitani, Takeshi Maruko, Kenji Sakamoto, Kunio Ishii.   

Abstract

The role of protease-activated receptor-2 (PAR-2) in the regulation of the rat urinary bladder contractility was investigated. Both trypsin and PAR-2 activating peptide (SLIGRL-NH(2)) produced a concentration-dependent contractile response in the urinary bladder preparations. These contractions were abolished by removal of the urinary bladder mucosa and were significantly reduced by indomethacin (10 microM). These results suggest that activation of PAR-2 stimulates release of prostaglandins from mucosal layer and thereby contracts rat urinary bladder smooth muscles.

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Year:  2003        PMID： 12595964     DOI： 10.1007/s00210-002-0687-y

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  16 in total

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5.  Elevated mast cell tryptase in the urine of patients with interstitial cystitis.

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Journal:  Br J Urol       Date:  1995-07

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Journal:  Br J Urol       Date:  1987-01

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Journal:  Proc Natl Acad Sci U S A       Date:  1998-06-09       Impact factor: 11.205

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Journal:  J Urol       Date:  1988-03       Impact factor: 7.450
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  11 in total

1.  Effect of aging on the response of biochemical markers in the rabbit subjected to short-term partial bladder obstruction.

Authors:  Ahmet Guven; Wei-Yu Lin; Robert E Leggett; Barry A Kogan; Robert M Levin; Anita Mannikarottu
Journal:  Mol Cell Biochem       Date:  2007-08-03       Impact factor: 3.396

Review 2.  Proteinase-activated receptors in the lower urinary tract.

Authors:  James D Moffatt
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2007-02-10       Impact factor: 3.000

Review 3.  Modulation of lower urinary tract smooth muscle contraction and relaxation by the urothelium.

Authors:  Donna Sellers; Russ Chess-Williams; Martin C Michel
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2018-05-28       Impact factor: 3.000

Review 4.  The Urothelium: Life in a Liquid Environment.

Authors:  Marianela G Dalghi; Nicolas Montalbetti; Marcelo D Carattino; Gerard Apodaca
Journal:  Physiol Rev       Date:  2020-03-19       Impact factor: 37.312

5.  Protease-activated receptor-2-mediated contraction of urinary bladder is enhanced in cyclophosphamide-treated rats.

Authors:  Tsutomu Nakahara; Yuko Kubota; Maki Saito; Kenji Sakamoto; Kunio Ishii
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2003-12-12       Impact factor: 3.000

6.  Possible involvement of Ca2+-independent phospholipase A2 in protease-activated receptor-2-mediated contraction of rat urinary bladder.

Authors:  Yuko Kubota; Tsutomu Nakahara; Akiko Mitani; Takeshi Maruko; Maki Saito; Kenji Sakamoto; Kunio Ishii
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2003-05-15       Impact factor: 3.000

7.  Extracts from Rhois aromatica and Solidaginis virgaurea inhibit rat and human bladder contraction.

Authors:  Verena E Borchert; Peter Czyborra; Charlotte Fetscher; Mark Goepel; Martin C Michel
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2004-02-13       Impact factor: 3.000

8.  Role of mast cells and protease-activated receptor-2 in cyclooxygenase-2 expression in urothelial cells.

Authors:  Zun-Yi Wang; Peiqing Wang; Dale E Bjorling
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2009-08-12       Impact factor: 3.619

Review 9.  Alpha1-, alpha2- and beta-adrenoceptors in the urinary bladder, urethra and prostate.

Authors:  Martin C Michel; Wim Vrydag
Journal:  Br J Pharmacol       Date:  2006-02       Impact factor: 8.739

10.  A new and automated method for objective analysis of detrusor rhythm during the filling phase.

Authors:  Adam P Klausner; Ashley B King; Michael D Byrne; Joseph R Habibi; Kai Li; Vikram Sabarwal; John E Speich; Paul H Ratz
Journal:  World J Urol       Date:  2013-04-30       Impact factor: 4.226
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