Literature DB >> 24434795

Seeing is believing: dynamic changes in renal epithelial autophagy during injury and repair.

Fangming Lin1, Zhao V Wang2, Joseph A Hill3.   

Abstract

Ischemic injury to the kidneys is a prevalent clinical problem, contributing importantly to chronic kidney disease. Yet, underlying molecular mechanisms are elusive. To address the possible role of autophagy, we engineered a novel strain of mice harboring a ubiquitously expressed CAG-RFP-EGFP-LC3 transgene. Using this tool, we examined the post-ischemic kidney and detailed the dynamics of renal tubular epithelial autophagy. In addition, we defined the role of MTOR in the resolution of autophagy during epithelial survival and kidney repair.

Entities:  

Keywords:  dymanics; ischemic injury; renal epithelial cells; renal repair; tandem fluorescence

Mesh：

Year:  2014        PMID： 24434795      PMCID： PMC4091155          DOI： 10.4161/auto.27749

Source DB:  PubMed          Journal:  Autophagy        ISSN： 1554-8627            Impact factor:   16.016


  6 in total

1.  Carbon Monoxide Activates PERK-Regulated Autophagy to Induce Immunometabolic Reprogramming and Boost Antitumor T-cell Function.

Authors:  Paramita Chakraborty; Rasesh Y Parikh; Seungho Choi; Danh Tran; Monika Gooz; Zachariah T Hedley; Do-Sung Kim; Dariusz Pytel; Inhong Kang; Satish N Nadig; Gyda C Beeson; Lauren Ball; Meenal Mehrotra; Hongjun Wang; Stefano Berto; Viswanathan Palanisamy; Hong Li; Shilpak Chatterjee; Paulo C Rodriguez; Eduardo N Maldonado; J Alan Diehl; Vamsi K Gangaraju; Shikhar Mehrotra
Journal:  Cancer Res       Date:  2022-05-16       Impact factor: 13.312

Review 2.  AKI on CKD: heightened injury, suppressed repair, and the underlying mechanisms.

Authors:  Liyu He; Qingqing Wei; Jing Liu; Mixuan Yi; Yu Liu; Hong Liu; Lin Sun; Youming Peng; Fuyou Liu; Manjeri A Venkatachalam; Zheng Dong
Journal:  Kidney Int       Date:  2017-09-08       Impact factor: 10.612

3.  αKlotho Mitigates Progression of AKI to CKD through Activation of Autophagy.

Authors:  Mingjun Shi; Brianna Flores; Nancy Gillings; Ao Bian; Han Jun Cho; Shirley Yan; Yang Liu; Beth Levine; Orson W Moe; Ming Chang Hu
Journal:  J Am Soc Nephrol       Date:  2015-12-23       Impact factor: 10.121

4.  Intravital imaging of mouse embryos.

Authors:  Qiang Huang; Malkiel A Cohen; Fernando C Alsina; Garth Devlin; Aliesha Garrett; Jennifer McKey; Patrick Havlik; Nikolai Rakhilin; Ergang Wang; Kun Xiang; Parker Mathews; Lihua Wang; Cheryl Bock; Victor Ruthig; Yi Wang; Marcos Negrete; Chi Wut Wong; Preetish K L Murthy; Shupei Zhang; Andrea R Daniel; David G Kirsch; Yubin Kang; Blanche Capel; Aravind Asokan; Debra L Silver; Rudolf Jaenisch; Xiling Shen
Journal:  Science       Date:  2020-04-10       Impact factor: 47.728

5.  Quantitative phosphoproteomic analyses identify STK11IP as a lysosome-specific substrate of mTORC1 that regulates lysosomal acidification.

Authors:  Zhenzhen Zi; Zhuzhen Zhang; Qiang Feng; Chiho Kim; Xu-Dong Wang; Philipp E Scherer; Jinming Gao; Beth Levine; Yonghao Yu
Journal:  Nat Commun       Date:  2022-04-01       Impact factor: 17.694

6.  MafK accelerates Salmonella mucosal infection through caspase-3 activation.

Authors:  Shiyao Xu; Guiqiu Hu; Di Wu; Xingchi Kan; Hisashi Oishi; Satoru Takahashi; Shoupeng Fu; Juxiong Liu; Chuan Zhang
Journal:  Aging (Albany NY)       Date:  2022-03-08       Impact factor: 5.682
  6 in total

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